EFFECT OF DIFFERENT ILLUMINATION SOURCES ON COLOUR AND OXIDATIVE STABILITY OF SEASONED COPPA DI PARMA PGI

The influence of different lighting durations, lamps and modified atmosphere packaging (MAP) on the colour and oxidative stability of lipids was studied in Coppa di Parma PGI. The samples were stored (4 degrees C) in darkness or lighted by UV-free lamps. In trials 1 and 2, the samples were lighted 24 and 12 h/day, respectively, and were packaged in air. In trial 3, samples were packaged in MA (70% N-2/30% CO2) and lighted 12 h/day. In air, illumination reduced oxidative stability, redness, colour saturation and increased the Hue angle. In MAP, the lighting conditions did not affect colour and oxidative stability. During storage the lipid oxidation increased. Overall, light negatively affected the studied parameters

Effects of dietary level of pantothenic acid and sex on carcass, meat quality traits and fatty acid composition of thigh subcutaneous adipose tissue in Italian heavy pigs.

Two trials were carried out to evaluate the effects of i) supranutritional doses of pantothenic acid (PA) and ii) sex on carcass, meat quality and fatty acid (FA) composition of subcutaneous adipose tissue in Italian heavy pig. In trial 1, 59 Duroc x (LxLW) pigs were fed the same diet containing either 10 [in the control (C) group] or 110 ppm [in the treatment (T) group] PA, from 107 to 168 kg live weight. At slaughtering, forty carcasses were sampled randomly. The T carcasses had lower backfat thickness (P<0.05), lower incidence of adipose cuts (P<0.05), higher lean cuts percentage (63.09 vs 60.64%; P<0.01) and lean meat yield (P<0.07). In trial 2, 42 pigs [Dumeco Cofok x (LxLW)], evenly divided into three groups, were fed the same feed containing respectively 10 (C), 60 (T1) and 110 ppm (T2) PA, from 95 to 165 kg live weight. The treatment lowered total adipose cuts yield (P<0.05) and increased lean/adipose cuts ratio (P<0.07). In the outer layer of thighs subcutaneous adipose tissue, the treatment raised polyunsaturated FA content (P<0.01), unsaturation coefficient (P<0.01) and polyunsaturated/saturated (P/S) FA ratio (P<0.05). In the inner layer, the treatment led to a lower saturated FA (P<0.05) and higher polyunsaturated FA content (P<0.01). In both trials, females generally provided leaner carcasses. In neither trials, vitamin level affected meat quality. Thus, feeding high levels of PA to heavy pigs can yield more valuable carcasses without affecting meat quality. However, effects on FA composition suggest caution in adopting this practice in the Italian heavy pig production

Effect of two sous-vide cooking methods on fatty acid composition and oxidative stability of longissimus thoracis muscle from pigs receiving a diet containing or not extruded linseed

To verify the effects of two different sous-vide cooking conditions on lipid oxidation and fatty acid (FA) composition of longissimus thoracis (LT) muscle, 24 pigs, evenly divided into two groups of 12 subjects each, were used. One group received a barley-soya bean meal diet (C) and the second was given the same feed where 5% of extruded linseed partly replaced barley, to obtain a n-3 FA enriched diet (L). At slaughter, from each left half carcase, two samples of LT muscle were collected, packed under vacuum and stored at −18 °C until analysis. The samples were cooked in water bath according to two different methods: at high temperature (80 °C) and short-time i.e. samples left until the core temperaturereached 70 °C (A); at low temperature (60 °C) and long-time (15 h) (B). After cooking, the samples were refrigerated (2 °C) for 24 h. Oxidative stability was measured by a dosage of the 2-thiobarbituric acid reactive substances (TBARS) content, expressed as milligrams of malondialdehyde (MDA)/kg of meat, and FA composition was determined by capillary gas chromatography. The content of each fatty acid is expressed as a percentage of the total FAs detected. The statistical analysis was performed by means of ANOVA, using the GLM procedure of SAS. Dietary treatment (C vs. L) and cooking condition (A vs. B) were used as independent variables. The different sous-vide cooking conditions affected neither lipid oxidation nor FAs percentage of LT muscle. Extruded linseed feeding brought about an increase of the percentage of total n–3 FA (2.67 vs. 0.98; p&lt;.01) and also of polyunsaturated fatty acids (12.02 vs. 9.68; p&lt;.01) in intramuscular fat but did not affect lipid oxidation. This enabled to obtain pork with a more favourable n–6/n–3 ratio (3.68 vs. 10.42 in L and C group, respectively; p&lt;.01), according to the global health guidelines. Thus, an enriched linseed diet ameliorates the FA composition of pork. The effect of the two different sous-vide cooking methods on lipid composition and oxidative stability of pork does not differ, irrespective of dietary treatments

EFFECTS OF DIETARY LINSEED AND SYNTHETIC OR NATURAL ANTIOXIDANTS ON SHELF-LIFE OF PORK

The effects of including extruded linseed in pig diets supplemented with either polyphenol-rich red grape skin extract (3 g kg(-1)) or synthetic antioxidants (200 mg kg(-1) alpha-tocopheryl acetate plus 0.21 mg kg(-1) of selenium) on shelf-life of pork stored in modified atmosphere packaging (MAP) at different oxygen concentrations (0 and 70%) were evaluated. Linseed reduced n-6/n-3 fatty acid ratio in lipids of backfat and loin. Color parameters, pH, weight losse, oxidative stability (TBARS), did not differ between antioxidants neither in raw, nor in cooked, nor in stored muscle. High oxygen concentration in MAP increased TBARS and Delta E, yielding redder meat

CHARACTERISTICS OF LIPIDS FROM IMMUNOCASTRATED MEDIUM-HEAVY PIGS FED EITHER A RESTRICTED DIET OR AD LIBITUM

We studied the feeding level-related variations in lipid characteristics in the adipose tissues of pigs. The lipid content, fatty acid profile, oxidative stability, iodine value, thrombogenic and atherogenic indices were determined in individual samples from 24 immunocastrated males (Duroc x Large White), fed either restricted or ad libitum. In backfat, feed restriction increased the polyunsaturated fatty acid proportion and iodine value and lowered the thrombogenic and atherogenic indices. Intramuscular lipid content was reduced by restriction, which did not affect either the fatty acid composition or the oxidative stability in both raw and cooked muscle. Feed restriction improved the nutritional quality of lipids without impairing their technological attributes

Safety of rituximab in rheumatoid arthritis

La artrite reumatoide \ue8 una malattia cronica che predispone alla comparsa di complicanze rappresentate da malattie infettive, neoplasie e malattie cardiovascolari. Il rischio \ue8 aumentato dalla necessit\ue0 di assumere a lungo farmaci immunomodultori, quali ad esempio i farmaci biotecnologici. La sicurezza del rituximab \ue8 stata valutata in un periodo di tempo medio (non superiore ai 10 anni) e i dati disponibili sono rassicuranti. Nei trials clinici condotti sia in pazienti gi\ue0 trattati (con antagonisti del TNF e/o con methotrexate) sia in pazienti naive \ue8 emerso che il rituximab \ue8 tollerato anche dopo diversi cicli di terapia. La percentuale totale di eventi avversi \ue8 infatti rimasta stabile nei vari cicli. L\u2019evento avverso pi\uf9 frequente era rappresentato dalla comparsa di reazioni infusionali. La percentuale di infezioni serie non aumentava dopo diversi cicli. I dati ottenuti da esperienze condotte nella vita quotidiana confermano il buon profilo di tollerabilit\ue0.Rheumatoid arthritis (RA) is a chronic disease that requires long-term administration of immunomodulatory drugs with a greater risk of side effects like malignancies, serious infections and cardiovascular diseases. Furthermore, patients with RA are more prone than the general population to these manifestations. Safety of rituximab has been evaluated in the short-term (6 months) and in the medium-term (up to 10 years) in patients who had been previously treated with antagonists of tumor necrosis factor (a-TNF) and/or with methotrexate (MTX) and in patients who were not. Data obtained from clinical trials demonstrated that rituximab is well tolerated either after a single course or after multiple courses. The overall rate of adverse events (AEs) was stable after the first three courses. The most frequent adverse event was infusion-related reactions (IRR). Serious infections did not increase after multiple courses. Data from "real life" confirm that treatment with rituximab is well tolerated

Anisakid and Raphidascaridid parasites in Trachurus trachurus: infection drivers and possible effects on the host’s condition

This study investigated the distribution of nematode larvae of Anisakidae and Raphidascarididae (genera Anisakis and Hysterothylacium) in Trachurus trachurus (Linnaeus, 1758) in the Ligurian and central-northern Tyrrhenian Seas. The relationship between the number of parasites and the length and weight parameters of the fish was assessed, and the possible effect of the parasites on the condition factor was evaluated. A total of 190&nbsp;T. trachurus specimens were collected in July 2019. Parasites were found in 70 individuals. A total of 161 visible larvae were collected in the viscera. Morphological analysis revealed the presence of Anisakis spp. in 55 fish and Hysterothylacium spp. in 15 fish, while 5 fish showed coinfection with both genera. The specimens subjected to PCR (n = 67) showed that 85% of the Anisakis larvae analyzed belonged to the species A. pegreffii, while the remaining 15% belonged to hybrids of A. pegreffii-A. simplex (s.s.). A total of 58% (n = 7) of the Hysterothylacium larvae analyzed belonged to the species H. fabri, while 42% belonged to the species H. aduncum. Our results support the hypothesis that infection with these parasites does not affect the condition of the fish host analyzed, and that body size and depth are major drivers in determining infection levels with Anisakid and Raphidascaridid nematodes

Effect of feeding maltodextrins and dextrose on rearing and slaughtering performance of immunocastrated male pigs

This study aimed to verify previous research findings showing that feeding maltodextrins (M) and dextrose (D) leads to a reduction of voluntary feed intake in the Italian heavy pig. This may be interesting for immunocastrated pigs fed ad libitum (ad lib.), whose feed intake skyrockets after the 2nd vaccination, causing too fatty carcasses at slaughtering. Thirty-six male pigs (Italian Duroc x Italian Large White crossbred) received a double immunocastrating injection at 90 and 162 days of age. At 120 days, weighing 51.84+4.38 kg, the subjects were evenly housed in 9 boxes, fed ad lib. till the 2nd injection and then given, until slaughtering (197 days of age; 144.51±9.70 kg), one of the experimental diets: control diet, ad lib. (CL); control diet, restricted at 7.5% l.w.0.75 (CR); with MD (3.5 + 3.5%; adjusted for energy and protein), ad lib. (MD). The CR diet was introduced as the alternative choice to avoid too fatty carcasses. Compared to the restricted ones, pigs fed ad lib. (with or without MD) showed statistically higher (P&lt;.01) ADG (1325 and 1325 vs 905 g/d), ADFI (4630 and 4637 vs 2760 g/d), feed:gain ratio (3.53 and 3.52 vs 3.11), and heavier carcasses (125.1 and 124.4 vs 113.2 kg; P&lt;.01) with lower lean meat content (52.21 and 52.09 vs 55.83 %; P&lt;.01). The results point out how immunocastrated pigs fed ad lib. showed similar rearing and slaughtering performance regardless of the inclusion of M and D in the diet

The Italian registry of aggressive rheumatoid arthritis -- the GIARA project.

Objective. In 1999, the Italian Society of Rheumatology started a project to determine the prevalence and clinical characteristics of aggressive rheumatoid arthritis (ARA). Methods. For I year, all patients with RA for 2 to 2 to 1.5, female sex, and RF positivity. Conditions other than RA were recorded in about 50% of the patients, and only 30%-40% were taking disease modifying antirheumatic drugs. Conclusion. In an Italian RA population, the GIARA (Gruppo Italiano Artrite Reumatoide Aggressiva) criteria for ARA were met by 15% of the patients with disease duration of 2 years, but erosions were seen in 35%. Upon referral, most of the RA patients were inadequately treated and had other conditions

X‐ray Tomography Unveils the Construction Technique of Un‐Montu’s Egyptian Coffin (Early 26th Dynasty)

The Bologna Archaeological Museum, in cooperation with prestigious Italian universities, institutions, and independent scholars, recently began a vast investigation programme on a group of Egyptian coffins of Theban provenance dating to the first millennium BC, primarily the 25th–26th Dynasty (c. 746–525 BC). Herein, we present the results of the multidisciplinary investigation car-ried out on one of these coffins before its restoration intervention: the anthropoid wooden coffin of Un‐Montu (Inv. MCABo EG1960). The integration of radiocarbon dating, wood species identifica-tion, and CT imaging enabled a deep understanding of the coffin’s wooden structure. In particular, we discuss the results of the tomographic investigation performed in situ. The use of a transportable X‐ray facility largely reduced the risks associated with the transfer of the large object (1.80 cm tall) out of the museum without compromising image quality. Thanks to the 3D tomographic imaging, the coffin revealed the secrets of its construction technique, from the rational use of wood to the employment of canvas (incamottatura), from the use of dowels to the assembly procedure