243 research outputs found
Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors
Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV. As attenuated tumour-selective oncolytic vaccinia viruses (VV) are already undergoing clinical evaluation, the goal of this study is to determine whether HDI can also enhance the potency of these poxviruses in infection-resistant cancer cell lines. Multiple HDIs were tested and Trichostatin A (TSA) was found to potently enhance the spread and replication of a tumour selective vaccinia virus in several infection-resistant cancer cell lines. TSA significantly decreased the number of lung metastases in a syngeneic B16F10LacZ lung metastasis model yet did not increase the replication of vaccinia in normal tissues. The combination of TSA and VV increased survival of mice harbouring human HCT116 colon tumour xenografts as compared to mice treated with either agent alone. We conclude that TSA can selectively and effectively enhance the replication and spread of oncolytic vaccinia virus in cancer cells. © 2010 MacTavish et al
Cosmic Microwave Background Polarization
Cosmic microwave background (CMB) anisotropy is our richest source of
cosmological information; the standard cosmological model was largely
established thanks to study of the temperature anisotropies. By the end of the
decade, the Planck satellite will close this important chapter and move us
deeper into the new frontier of polarization measurements. Numerous
ground--based and balloon--borne experiments are already forging into this new
territory. Besides providing new and independent information on the primordial
density perturbations and cosmological parameters, polarization measurements
offer the potential to detect primordial gravity waves, constrain dark energy
and measure the neutrino mass scale. A vigorous experimental program is
underway worldwide and heading towards a new satellite mission dedicated to CMB
polarization.Comment: Review given at TAUP 2005; References added; Additional reference
Instrumental and Analytic Methods for Bolometric Polarimetry
We discuss instrumental and analytic methods that have been developed for the
first generation of bolometric cosmic microwave background (CMB) polarimeters.
The design, characterization, and analysis of data obtained using Polarization
Sensitive Bolometers (PSBs) are described in detail. This is followed by a
brief study of the effect of various polarization modulation techniques on the
recovery of sky polarization from scanning polarimeter data. Having been
successfully implemented on the sub-orbital Boomerang experiment, PSBs are
currently operational in two terrestrial CMB polarization experiments (QUaD and
the Robinson Telescope). We investigate two approaches to the analysis of data
from these experiments, using realistic simulations of time ordered data to
illustrate the impact of instrumental effects on the fidelity of the recovered
polarization signal. We find that the analysis of difference time streams takes
full advantage of the high degree of common mode rejection afforded by the PSB
design. In addition to the observational efforts currently underway, this
discussion is directly applicable to the PSBs that constitute the polarized
capability of the Planck HFI instrument.Comment: 23 pages, 11 figures. for submission to A&
Probing for cosmological parameters with LAMOST measurement
In this paper we study the sensitivity of the Large Sky Area Multi-Object
Fiber Spectroscopic Telescope (LAMOST) project to the determination of
cosmological parameters, employing the Monte Carlo Markov Chains (MCMC) method.
For comparison, we first analyze the constraints on cosmological parameters
from current observational data, including WMAP, SDSS and SN Ia. We then
simulate the 3D matter power spectrum data expected from LAMOST, together with
the simulated CMB data for PLANCK and the SN Ia from 5-year Supernovae Legacy
Survey (SNLS). With the simulated data, we investigate the future improvement
on cosmological parameter constraints, emphasizing the role of LAMOST. Our
results show the potential of LAMOST in probing for the cosmological
parameters, especially in constraining the equation-of-state (EoS) of the dark
energy and the neutrino mass.Comment: 7 pages and 3 figures. Replaced with version accepted for publication
in JCA
SPIDER: a balloon-borne CMB polarimeter for large angular scales
We describe SPIDER, a balloon-borne instrument to map the polarization of the
millimeter-wave sky with degree angular resolution. Spider consists of six
monochromatic refracting telescopes, each illuminating a focal plane of
large-format antenna-coupled bolometer arrays. A total of 2,624 superconducting
transition-edge sensors are distributed among three observing bands centered at
90, 150, and 280 GHz. A cold half-wave plate at the aperture of each telescope
modulates the polarization of incoming light to control systematics. Spider's
first flight will be a 20-30-day Antarctic balloon campaign in December 2011.
This flight will map \sim8% of the sky to achieve unprecedented sensitivity to
the polarization signature of the gravitational wave background predicted by
inflationary cosmology. The Spider mission will also serve as a proving ground
for these detector technologies in preparation for a future satellite mission.Comment: 12 pages, 6 figures; as published in the conference proceedings for
SPIE Millimeter, Submillimeter, and Far-Infrared Detectors and
Instrumentation for Astronomy V (2010
Cosmology with CMB anisotropy
Measurements of CMB anisotropy and, more recently, polarization have played a
very important role allowing precise determination of various parameters of the
`standard' cosmological model. The expectation of the paradigm of inflation and
the generic prediction of the simplest realization of inflationary scenario in
the early universe have also been established -- `acausally' correlated initial
perturbations in a flat, statistically isotropic universe, adiabatic nature of
primordial density perturbations. Direct evidence for gravitational instability
mechanism for structure formation from primordial perturbations has been
established. In the next decade, future experiments promise to strengthen these
deductions and uncover the remaining crucial signature of inflation -- the
primordial gravitational wave background.Comment: Plenary talk at the IXth. International Workshop on High Energy
Physics Phenomenology (WHEPP-9), Institute of Physics, Bhubaneshwar, India.
Jan 3-14, 2006; To appear in the Proceedings to be published in Pramana; 12
pages, 2 figure
Early Dark Energy Cosmologies
We propose a novel parameterization of the dark energy density. It is
particularly well suited to describe a non-negligible contribution of dark
energy at early times and contains only three parameters, which are all
physically meaningful: the fractional dark energy density today, the equation
of state today and the fractional dark energy density at early times. As we
parameterize Omega_d(a) directly instead of the equation of state, we can give
analytic expressions for the Hubble parameter, the conformal horizon today and
at last scattering, the sound horizon at last scattering, the acoustic scale as
well as the luminosity distance. For an equation of state today w_0 < -1, our
model crosses the cosmological constant boundary. We perform numerical studies
to constrain the parameters of our model by using Cosmic Microwave Background,
Large Scale Structure and Supernovae Ia data. At 95% confidence, we find that
the fractional dark energy density at early times Omega_early < 0.06. This
bound tightens considerably to Omega_early < 0.04 when the latest Boomerang
data is included. We find that both the gold sample of Riess et. al. and the
SNLS data by Astier et. al. when combined with CMB and LSS data mildly prefer
w_0 < -1, but are well compatible with a cosmological constant.Comment: 6 pages, 3 figures; references added, matches published versio
Cosmological Parameters from the 2003 flight of BOOMERANG
We present the cosmological parameters from the CMB intensity and
polarization power spectra of the 2003 Antarctic flight of the BOOMERANG
telescope. The BOOMERANG data alone constrains the parameters of the
CDM model remarkably well and is consistent with constraints from a
multi-experiment combined CMB data set. We add LSS data from the 2dF and SDSS
redshift surveys to the combined CMB data set and test several extensions to
the standard model including: running of the spectral index, curvature, tensor
modes, the effect of massive neutrinos, and an effective equation of state for
dark energy. We also include an analysis of constraints to a model which allows
a CDM isocurvature admixture.Comment: 18 pages, 10 figures, submitted to Ap
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