Prevalence of HCV NS3 pre-treatment resistance associated amino acid variants within a Scottish cohort

Background: Protease inhibitors (PI) including boceprevir, telaprevir and simeprevir have revolutionised HCV genotype 1 treatment since their introduction. A number of pre-treatment resistance associated amino acid variants (RAVs) and polymorphisms have been associated with reduced response to treatment. Objectives: We measured the prevalence of RAVs/polymorphisms in a PI treatment-naïve HCV genotype 1 Scottish cohort using Sanger sequencing. Study design: Chronically infected, treatment-naïve, HCV genotype 1 patients (n = 146) attending NHS Greater Glasgow and Clyde clinics were investigated for RAVs/polymorphisms to the PIs boceprevir, telaprevir and simeprevir. The NS3/4A region was amplified by nested polymerase chain reaction. The 1.4 kb amplified product was sequenced using an ABI 3710XL DNA sequencer. Sequence analysis was performed using web-based ReCall (beta 2.10). Amino acid positions 36, 41, 43, 54, 55, 80, 109, 122, 155, 156, 168 and 170 were analysed for RAVs/polymorphisms. Results: Overall, 23.29% (34/146) of patients had an RAV or polymorphism detected. Overall, 13.69% (20/146) of patients had HCV virus that contained the Q8 K polymorphism. Other RAVs detected were: V36 M 0.70% (1/146), V36L 0.70% (1/146), T54S 6.85% (10/146), V55A 3.42% (5/146) and V/I170A 0.68% (1/146). Four patients had dual combinations of mutations (T54S + V36L; T54S + V55A and 2 patients with T54S + Q80K). Conclusions: Q80K was the most prevalent baseline polymorphism detected in the Scottish cohort. Simeprevir treatment is not recommended in patients infected with the Q80K genotype 1a variant. This highlights the need for baseline sequencing prior to administration of this drug in this population

Female Narcissism: Assessment, Aetiology, and Behavioural Manifestations

Despite putative gender differences in the expression of narcissism, prominent theories have virtually dismissed the role of females in the development and manifestation of narcissism. The contention that narcissism is a pathology of the self that may partly differ in males and females is further evident in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). The DSM-5 reports that up to 75% of those diagnosed with Narcissistic Personality Disorder (NPD) are men. Such figures suggest that the representation of narcissism as codified in the DSM-5 may only be marginally applicable to females, given its prominent focus and nature on capturing grandiose themes which closely resemble commonly masculine norms. The overemphasis on grandiose features extends to the empirical literature which defines narcissism as a normative personality trait and is widely assessed using the Narcissistic Personality Inventory (NPI), on which males obtain significantly higher scores than females. As this review will demonstrate, one limitation frequently occurring in the literature is the attempt to comprehend narcissistic manifestations in females through the lens of what has commonly been defined as narcissism (DSM/NPI). In this review, the literature concerning the diagnostic assessment and conceptualization of narcissistic personality disorder, etiological factors, aggression, and partner violence perpetration will be discussed in relation to the importance of gender. This is followed by a review of existing gaps in theory and research, and suggestions for fruitful directions that can aid a richer and more meaningful literature on narcissism inclusive of gender issues

Perceptions of female narcissism in intimate partner violence: A thematic analysis

This study sought to explicitly investigate manifestations off ema/,e narcissism and their attempts at self-regulation in the context of intimate partner violence (IPV). This navel phenomenon was explored through the lens of ex-partners' perceptions of female narcissists. A qualitative approach using individual interviews was adopted to gain an in-depth insight of the subtleties and nuances of gender differences in narcissistic personality. Semi-structured interviews were carried out with ten male participants who repurted having experienced an abusive relationship with a female narcissist. These interviews were transcribed and analysed using thematic analysis. Three overarching themes emerged from the data analysis: (i) dualistic personas of narcissism; (ii) the mask of femininity; and (iii) the hidden paradox of gender roles. Findings illustrated that perceived expressions of female narcissists depicted presentations of narcissistic vulnerability. Analysis also demonstrated that gender-related norms further shaped motives and self-regulatury strategies for females to obtain positions of power and control. These were established through adopting a 'victim status', playing the 'mother card' and using legal and societal benefits to their advantage. Female narcissists were perceived to employ strategic attempts at self-construction in sinister and abusive ways, governed by what society allows them to express. It is concluded that narcissism describes a phenomenon in females that move beyond the overt grandiose stereotype. Limitations and suggestions for future re.search are discussed

Clinician perception of pathological narcissism in females: a vignette-based study

The DSM-5 reports that up to 75% of those diagnosed with Narcissistic Personality Disorder (NPD) are males, which denotes that narcissism is a clinical phenomenon that operates differently in men and women. Vulnerable narcissism, which tends to be more prevalent in females and is currently under-appreciated in the DSM-5, may be diagnosed as other “vulnerable” disorders (e.g., Borderline Personality Disorder; BPD). The current study investigated gender differences in clinicians’ perceptions of narcissistic pathology. Adopting an online vignette-based study, clinicians (N = 108; 79 females) read clinical case vignettes of hypothetical patients and provided diagnostic ratings of existing personality disorders. Clinicians’ diagnostic ratings of NPD were concurrent with the vignette containing grandiose narcissism symptoms, irrespective of patient gender. However, when presented with a vulnerable narcissism vignette, clinicians were significantly more likely to attribute a BPD diagnosis in female patients, compared to male patients. Clinicians with a psychodynamic approach and more experience in practice were also more likely to label vulnerable narcissism symptoms as NPD, compared to those with a CBT approach and less experience in practice. The clinical implications of these results support the shift toward assessing personality dysfunction based on dimensional trait domains

The relationship between creativity and attention in adults

Creativity is a valuable attribute that involves the generation of original ideas; attention is a vital function that facilitates information selection. There is some evidence that creative people may have poorer attention and are generally more distracted than others, and this distractibility is thought to enable the production of novel ideas. Previous research has largely supported this relationship between creativity and attention, yet they are both multifaceted constructs that can be measured in numerous ways. Using multiple measures of each construct, the aim of this study was to examine which features of creativity and attention might be related in a group of 100 adults (18-80 years, M = 26.9, SD = 11.5). Figural divergent-thinking (DT) originality was positively related to self-reported concentration; yet no other relationships were found. Results suggest that there is no consistent relationship between creativity and attention, and past studies that linked creativity to attention, having used just one or two measures, may be premature in their conclusions

The relationship between creativity and attention in adults

Creativity is a valuable attribute that involves the generation of original ideas; attention is a vital function that facilitates information selection. There is some evidence that creative people may have poorer attention and are generally more distracted than others, and this distractibility is thought to enable the production of novel ideas. Previous research has largely supported this relationship between creativity and attention, yet they are both multifaceted constructs that can be measured in numerous ways. Using multiple measures of each construct, the aim of this study was to examine which features of creativity and attention might be related in a group of 100 adults (18-80 years, M = 26.9, SD = 11.5). Figural divergent-thinking (DT) originality was positively related to self-reported concentration; yet no other relationships were found. Results suggest that there is no consistent relationship between creativity and attention, and past studies that linked creativity to attention, having used just one or two measures, may be premature in their conclusions

Determinants of psychological distress in teenagers and young adults affected by cancer: a systematic review and meta-analysis. [Protocol]

The objective of this systematic review is to look at the key determinants of psychological distress in teenagers and young adults (TYAs) affected by cancer. Sources to be searched are MEDLINE, PsycINFO, CINAHL, the Cochrane Database of Systematic Reviews, EMBASE and PsycARTICLES. Any quantitative studies that assess the association among different factors (including individual and contextual types of factors commonly explored in the available literature in the subject area) with psychological distress will be included e.g. cross-sectional and longitudinal studies. Participants will be teenagers and young adults (TYA) a) aged 13-24 years at cancer diagnosis (in line with Teenage Cancer Trust’s definition b) at any stage of cancer, c) diagnosed with anxiety, depression, or/and PTSD or reported depressive/anxiety/PTSD symptomatology (on a validated self-report or clinician measure)

Decision science: a new hope

Decision science is an area of enquiry that crosses many disciplines, from psychology to economics, each with their own perspective of decision making. Traditionally, mathematicians have envisaged decision making as a purely rational endeavour, whereas psychologists and behavioural economists have critiqued this narrative, and suggested that cognitive short cuts are the real mechanisms behind how decisions are made. However, contemporary dual process theorists argue that two systems of the mind exist: system one (intuitive decision making); and, system two (rational decision making). The current review will present a relatively new metaphor for decision making: the unified threshold model. This model is a global approach to decision making which allows both intuitive and rational decision making processes to be explained in a more flexible manner than the dual process model. This review will introduce the reader to different types of threshold models (Counter and Diffusion), their assumptions, and their ability to explain decision making behaviour. Implications and future research will also be discussed. In summary, the aim of this review is to highlight that the unified threshold model of decision making may be a more adequate explanation of decision making data in comparison to previous models and theorie

The Determinants of Well-being among Polish Economic Immigrants. Testing The Sustainable Happiness Model in Migrant Population

Economic migration has increased dramatically over the past decades, yet, still little is known about the well-being of economic migrants. Most studies focus on the poor mental health of migrants. The few studies that examine well-being do not include a comprehensive range of predictors. They focus mostly on socio-economic factors and a limited number of cognitive-behavioural factors. Furthermore, most research is not theoretically based. The present study aims to (1) examine a comprehensive range of determinants of well-being (i.e. circumstantial, cognitive-behavioural and personality) among economic migrants; (2) establish the extent to which the findings are supported by an integrative theory of well-being—the Sustainable Happiness Model (SHM). A total of 188 Polish immigrants living in Scotland took part in the study. Participants completed a survey on well-being and potential predictors: circumstantial factors (e.g. socio-demographics), cognitive-behavioural factors (e.g. coping strategies) and personality. The data were analysed by descriptive statistics, multiple and hierarchical regression. The results indicated that cognitive-behavioural factors account for most variance in well-being and personality explains the least variance. This contradicts the SHM which posits that well-being is mostly accounted for by the set-point. It was argued that the SHM, largely based on studies conducted on non-migrant populations in developed countries, may not be applicable in its current form to economic migrant populations or non-western cultures. A modified model is proposed to explain well-being of migrant populations and non-western, more collectivistic societies. The study highlights the importance of addressing migrants’ adverse circumstances to help maintain well-being

Decision science: a new hope

Decision science is an area of enquiry that crosses many disciplines, from psychology to economics, each with their own perspective of decision making. Traditionally, mathematicians have envisaged decision making as a purely rational endeavour, whereas psychologists and behavioural economists have critiqued this narrative, and suggested that cognitive short cuts are the real mechanisms behind how decisions are made. However, contemporary dual process theorists argue that two systems of the mind exist: system one (intuitive decision making); and, system two (rational decision making). The current review will present a relatively new metaphor for decision making: the unified threshold model. This model is a global approach to decision making which allows both intuitive and rational decision making processes to be explained in a more flexible manner than the dual process model. This review will introduce the reader to different types of threshold models (Counter and Diffusion), their assumptions, and their ability to explain decision making behaviour. Implications and future research will also be discussed. In summary, the aim of this review is to highlight that the unified threshold model of decision making may be a more adequate explanation of decision making data in comparison to previous models and theorie