13,448 research outputs found
The ‘EDHF’ Antagonist 14, 15 Epoxyeicosa-5(Z)-Enoic Acid has Vasodilator Properties in Mesenteric Vessels
There is now overwhelming evidence for Epoxyeicosatrienoic acids (EETs) as endothelial derived hyperpolarising factor (EDHF). Most recently, a number of pharmacological tools have been developed for the study of EETs in relation to EDHF responses. EETs have been shown to cause relaxation by activating smooth muscle large conductance Ca2+ sensitive K+ (BKCa) (Archer et al, 2003). This dilatory response has been shown to be specifically inhibited by its analogue 14, 15-epoxyeicosa-5 (Z) enoic acid (14, 15 EEZE) in both human internal mammary artery and bovine coronary artery (Archer et al, 2003). Here we have investigated the antagonist effects of 14, 15 EEZE in murine arteries. Male Black 6 mice (12-18 weeks) were killed by lethal exposure to CO2. First order arteries were isolated and mounted in wire myographs immersed in physiological salt solution (PSS). Arteries were equilibrated (30 mins) and tensions normalised as described previously (Mulvany and Halpern, 1977). Arteries incubated for 30 minutes with or without 3µg/ml 14, 15 EEZE. A concentration response curve to 11, 12 EET was performed cumulatively on arteries pre-contracted with EC80 U46619. In some experiments, arteries were pre-contracted with EC80 U46619, and concentration response to 14, 15 EEZE performed cumulatively.Non peer reviewe
Pressure study of nematicity and quantum criticality in SrRuO for an in-plane field
We study the relationship between the nematic phases of SrRuO and
quantum criticality. At ambient pressure, one nematic phase is associated with
a metamagnetic quantum critical end point (QCEP) when the applied magnetic
field is near the \textit{c}-axis. We show, however, that this metamagnetic
transition does not produce the same nematic signatures when the QCEP is
reached by hydrostatic pressure with the field applied in the
\textit{ab}-plane. Moreover, a second nematic phase, that is seen for field
applied in the \textit{ab}-plane close to, but not right at, a second
metamagnetic anomaly, persists with minimal change to the highest applied
pressure, 16.55 kbar. Taken together our results suggest that metamagnetic
quantum criticality may not be necessary for the formation of a nematic phase
in SrRuO
Validity of the Adiabatic Approximation
We analyze the validity of the adiabatic approximation, and in particular the
reliability of what has been called the "standard criterion" for validity of
this approximation. Recently, this criterion has been found to be insufficient.
We will argue that the criterion is sufficient only when it agrees with the
intuitive notion of slowness of evolution of the Hamiltonian. However, it can
be insufficient in cases where the Hamiltonian varies rapidly but only by a
small amount. We also emphasize the distinction between the adiabatic {\em
theorem} and the adiabatic {\em approximation}, two quite different although
closely related ideas.Comment: 4 pages, 1 figur
A new perturbative approach to the adiabatic approximation
A new and intuitive perturbative approach to time-dependent quantum mechanics
problems is presented, which is useful in situations where the evolution of the
Hamiltonian is slow. The state of a system which starts in an instantaneous
eigenstate of the initial Hamiltonian is written as a power series which has a
straightforward diagrammatic representation. Each term of the series
corresponds to a sequence of "adiabatic" evolutions, during which the system
remains in an instantaneous eigenstate of the Hamiltonian, punctuated by
transitions from one state to another. The first term of this series is the
standard adiabatic evolution, the next is the well-known first correction to
it, and subsequent terms can be written down essentially by inspection.
Although the final result is perhaps not terribly surprising, it seems to be
not widely known, and the interpretation is new, as far as we know. Application
of the method to the adiabatic approximation is given, and some discussion of
the validity of this approximation is presented.Comment: 9 pages. Added references, discussion of previous results, expanded
upon discussion of main result and application of i
Detailed Topography of the Fermi Surface of Sr2RuO4
We apply a novel analysis of the field and angle dependence of the
quantum-oscillatory amplitudes in the unconventional superconductor Sr2RuO4 to
map its Fermi surface in unprecedented detail, and to obtain previously
inaccessible information on the band dispersion. The three quasi-2D Fermi
surface sheets not only exhibit very diverse magnitudes of warping, but also
entirely different dominant warping symmetries. We use the data to reassess
recent results on c-axis transport phenomena.Comment: REVTeX, 4 page
Maxwell-Chern-Simons Q-balls
We examine the energetics of -balls in Maxwell-Chern-Simons theory in two
space dimensions. Whereas gauged -balls are unallowed in this dimension in
the absence of a Chern-Simons term due to a divergent electromagnetic energy,
the addition of a Chern-Simons term introduces a gauge field mass and renders
finite the otherwise-divergent electromagnetic energy of the -ball. Similar
to the case of gauged -balls, Maxwell-Chern-Simons -balls have a maximal
charge. The properties of these solitons are studied as a function of the
parameters of the model considered, using a numerical technique known as
relaxation. The results are compared to expectations based on qualitative
arguments.Comment: 6 pages. Talk given at Theory CANADA 2, Perimeter Institut
Non-Singular Stationary Global Strings
A field-theoretical model for non-singular global cosmic strings is
presented. The model is a non-linear sigma model with a potential term for a
self-gravitating complex scalar field. Non-singular stationary solutions with
angular momentum and possibly linear momentum are obtained by assuming an
oscillatory dependence of the scalar field on t, phi and z. This dependence has
an effect similar to gauging the global U(1) symmetry of the model, which is
actually a Kaluza-Klein reduction from four to three spacetime dimensions. The
method of analysis can be regarded as an extension of the
gravito-electromagnetism formalism beyond the weak field limit. Some D=3
self-dual solutions are also discussed.Comment: 20 pages Latex, 12 PS figures included. Minor corrections. Version to
appear in Phys.Rev.
Rigid-Band Shift of the Fermi Level in a Strongly Correlated Metal: Sr(2-y)La(y)RuO(4)
We report a systematic study of electron doping of Sr2RuO4 by non-isovalent
substitution of La^(3+) for Sr^(2+). Using a combination of de Haas-van Alphen
oscillations, specific heat, and resistivity measurements, we show that
electron doping leads to a rigid-band shift of the Fermi level corresponding to
one doped electron per La ion, with constant many-body quasiparticle mass
enhancement over the band mass. The susceptibility spectrum is substantially
altered and enhanced by the doping but this has surprisingly little effect on
the strength of the unconventional superconducting pairing.Comment: 4 pages, 3 figure
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