Experimental software engineering in educational context

Empirical studies are important in software engineering to evaluate new tools, techniques, methods and technologies in a structured way before they are introduced in the industrial (real) software process. Within this PhD thesis we will develop a framework of a consistent process for involving students as subjects of empirical studies of software engineering. In concrete, our experiences with software development teams composed of students will analyze how RUP (Rational Unified Process) processes can be compliant with the CMMI (Capability Maturity Model Integration), namely in the context of MLs (maturity levels) 2 and 3. Additionally, we will also analyze the influence of project management tools to improve the process maturity of the teams. Our final goal of carrying out empirical studies with students is to understand its validity when compared with the corresponding studies in real industrial settings

Architectural element points: estimating software development effort by analysis of logical architectures

Empirical studies are important in software engineering to evaluate new tools, techniques, methods and technologies. In object-oriented analysis, use case models describe the functional requirements of a software system, so they can be the basis for software measurement and sizing. The purpose of this study is to develop a new metric called Architectural Element Points (AEPoint) that enables to calculate the effort required to develop a software solution, using the 4-Step Rule Set (4SRS) method. This paper describes a case study with 60 undergraduate students grouped in four teams that developed a software system (Web application) for a real customer. In this study, we used the AEPoint metric to estimate the resources needed to develop a software system. The results of the AEPoint and Use Case Points (UCP) metrics and the real software development effort are compared, conclusions drawn and recommendations are proposed.info:eu-repo/semantics/publishedVersio

Mimics and Pitfalls of Imaging Assessment

Axial spondyloarthritis (axSpA) is a chronic inflammatory disorder that predominantly involves the axial skeleton. Imaging findings of axSpA can be divided into active changes, which include bone marrow edema, synovitis, enthesitis, capsulitis, and intra-articular effusion, and structural changes, which include erosions, sclerosis, bone fatty infiltration, fat deposition in an erosion cavity, and bone bridging or ankylosis. The ability to distinguish between imaging lesions suggestive of axSpA and artifacts or lesions suggestive of other disorders is critical for the accurate diagnosis of axSpA. Diagnosis may be challenging, particularly in early-stage disease and magnetic resonance imaging (MRI) plays a key role in the detection of subtle or inflammatory changes. MRI also allows the detection of structural changes in the subchondral bone marrow that are not visible on conventional radiography and is of prognostic and monitoring value. However, bone structural changes are more accurately depicted using computed tomography. Conventional radiography, on the other hand, has limitations, but it is easily accessible and may provide insight on gross changes as well as rule out other pathological features of the axial skeleton. This review outlines the imaging evaluation of axSpA with a focus on imaging mimics and potential pitfalls when assessing the axial skeleton.publishersversionpublishe

Inclusion body myositis: from genetics to clinical trials

Inclusion body myositis (IBM) belongs to the group of idiopathic inflammatory myopathies and is characterized by a slowly progressive disease course with asymmetric muscle weakness of predominantly the finger flexors and knee extensors. The disease leads to severe disability and most patients lose ambulation due to lack of curative or disease-modifying treatment options. Despite some genes reported to be associated with hereditary IBM (a distinct group of conditions), data on the genetic susceptibility of sporadic IBM are very limited. This review gives an overview of the disease and focuses on the current genetic knowledge and potential therapeutic implications

An empirical study on the estimation of size and complexity of software applications with function points analysis

Empirical studies are important in software engineering to evaluate new tools, techniques, methods and technologies in a structured way before they are introduced in the industrial (real) software process. Perform empirical studies in a real context is very difficult due to various obstacles. An interesting alternative is perform empirical studies in an educational context using students as subjects and share the results with the academia and the industry. This paper describes a case study with two teams that developed a software system (Web application) for a real customer. In this study we used a model based on Function Points Analysis (FPA) to estimate the size and complexity of software system

Diagnostic and prognostic value of anti-cN1A antibodies in inclusion body myositis

Inclusion body myositis (IBM) is an acquired idiopathic inflammatory myopathy more commonly seen in individuals aged above 50. Unlike other idiopathic inflammatory myopathies, there is no response to immunosuppression/immunomodulation. The lack of response to such therapies led the focus away from considering IBM as a purely immune-mediated condition. However, the discovery of antibodies against cytosolic 5'-nucleotidase 1A (cN1A) in patients with IBM has reinvig-orated interest in autoimmunity as a key role in its pathogenesis. Over the last decade different methods have been developed to detect anti-cN1A antibodies. There has been an interest in whether these assays can be utilised in the diagnosis of IBM. Furthermore, there has been focus on whether anti-cN1A antibodies can be used to prognosticate and predict the clinical phenotype in IBM. Anti-cN1A antibodies appear to have a high specificity and moderate sensitivity for IBM. There have been some exploratory clinicopathological associations described in seropositive IBM patients, but sample sizes in most studies have been small so far. Antibody testing is yet to be standardised; which somewhat limits our ability to draw robust conclusions from current investi-gations. In this article we review the literature on anti-cN1A antibodies and discuss whether they have a role in clinical practice