Modification of Projected Velocity Power Spectra by Density Inhomogeneities in Compressible Supersonic Turbulence

(Modified) The scaling of velocity fluctuation, dv, as a function of spatial scale L in molecular clouds can be measured from size-linewidth relations, principal component analysis, or line centroid variation. Differing values of the power law index of the scaling relation dv = L^(g3D) in 3D are given by these different methods: the first two give g3D=0.5, while line centroid analysis gives g3D=0. This discrepancy has previously not been fully appreciated, as the variation of projected velocity line centroid fluctuations (dv_{lc} = L^(g2D)) is indeed described, in 2D, by g2D=0.5. However, if projection smoothing is accounted for, this implies that g3D=0. We suggest that a resolution of this discrepancy can be achieved by accounting for the effect of density inhomogeneity on the observed g2D obtained from velocity line centroid analysis. Numerical simulations of compressible turbulence are used to show that the effect of density inhomogeneity statistically reverses the effect of projection smoothing in the case of driven turbulence so that velocity line centroid analysis does indeed predict that g2D=g3D=0.5. Using our numerical results we can restore consistency between line centroid analysis, principal component analysis and size-linewidth relations, and we derive g3D=0.5, corresponding to shock-dominated (Burgers) turbulence. We find that this consistency requires that molecular clouds are continually driven on large scales or are only recently formed.Comment: 28 pages total, 20 figures, accepted for publication in Ap

Ultrasensitivity in phosphorylation-dephosphorylation cycles with little substrate

Cellular decision-making is driven by dynamic behaviours, such as the preparations for sunrise enabled by circadian rhythms and the choice of cell fates enabled by positive feedback. Such behaviours are often built upon ultrasensitive responses where a linear change in input generates a sigmoidal change in output. Phosphorylation-dephosphorylation cycles are one means to generate ultrasensitivity. Using bioinformatics, we show that in vivo levels of kinases and phosphatases frequently exceed the levels of their corresponding substrates in budding yeast. This result is in contrast to the conditions often required by zero-order ultrasensitivity, perhaps the most well known means for how such cycles become ultrasensitive. We therefore introduce a mechanism to generate ultrasensitivity when numbers of enzymes are higher than numbers of substrates. Our model combines distributive and non-distributive actions of the enzymes with two-stage binding and concerted allosteric transitions of the substrate. We use analytical and numerical methods to calculate the Hill number of the response. For a substrate with [Formula: see text] phosphosites, we find an upper bound of the Hill number of [Formula: see text], and so even systems with a single phosphosite can be ultrasensitive. Two-stage binding, where an enzyme must first bind to a binding site on the substrate before it can access the substrate's phosphosites, allows the enzymes to sequester the substrate. Such sequestration combined with competition for each phosphosite provides an intuitive explanation for the sigmoidal shifts in levels of phosphorylated substrate. Additionally, we find cases for which the response is not monotonic, but shows instead a peak at intermediate levels of input. Given its generality, we expect the mechanism described by our model to often underlay decision-making circuits in eukaryotic cells

Compound Preposition of Minangkabau Language

Some Minangkabau prepositions have high ability of combining with each other, they are: (a) bak ‘like', (b) cando ‘like',  (c) dari ‘from', (d) daripado ‘than',  (e) dek ‘ because, at, by, (f) di ‘at' (g) jo‘with', (h) kacuali ‘except', and (i) kapado ‘to' (j)  sampai ‘until'. There are 2 categories of compound prepositions. Fisrt, some of the compound prepositions are the combination of two prepositions that have same meaning (synonym). One of the compound synonym prepositions can be deleted in their structure environment by using ellipsis technique and the deletion does not disturb the compound meaning. Second, the combination of two or more than two prepositions that have different meaning. Ellipsis cannot be applied to these compound prepositions

Endomorphisms and automorphisms of locally covariant quantum field theories

In the framework of locally covariant quantum field theory, a theory is described as a functor from a category of spacetimes to a category of *-algebras. It is proposed that the global gauge group of such a theory can be identified as the group of automorphisms of the defining functor. Consequently, multiplets of fields may be identified at the functorial level. It is shown that locally covariant theories that obey standard assumptions in Minkowski space, including energy compactness, have no proper endomorphisms (i.e., all endomorphisms are automorphisms) and have a compact automorphism group. Further, it is shown how the endomorphisms and automorphisms of a locally covariant theory may, in principle, be classified in any single spacetime. As an example, the endomorphisms and automorphisms of a system of finitely many free scalar fields are completely classified.Comment: v2 45pp, expanded to include additional results; presentation improved and an error corrected. To appear in Rev Math Phy

The Influence of Metallicity on Star Formation in Protogalaxies

In cold dark matter cosmological models, the first stars to form are believed to do so within small protogalaxies. We wish to understand how the evolution of these early protogalaxies changes once the gas forming them has been enriched with small quantities of heavy elements, which are produced and dispersed into the intergalactic medium by the first supernovae. Our initial conditions represent protogalaxies forming within a fossil H II region, a previously ionized region that has not yet had time to cool and recombine. We study the influence of low levels of metal enrichment on the cooling and collapse of ionized gas in small protogalactic halos using three-dimensional, smoothed particle hydrodynamics (SPH) simulations that incorporate the effects of the appropriate chemical and thermal processes. Our previous simulations demonstrated that for metallicities Z < 0.001 Z_sun, metal line cooling alters the density and temperature evolution of the gas by less than 1% compared to the metal-free case at densities below 1 cm-3) and temperatures above 2000 K. Here, we present the results of high-resolution simulations using particle splitting to improve resolution in regions of interest. These simulations allow us to address the question of whether there is a critical metallicity above which fine structure cooling from metals allows efficient fragmentation to occur, producing an initial mass function (IMF) resembling the local Salpeter IMF, rather than only high-mass stars.Comment: 3 pages, 2 figures, First Stars III conference proceeding

Causal sites as quantum geometry

We propose a structure called a causal site to use as a setting for quantum geometry, replacing the underlying point set. The structure has an interesting categorical form, and a natural "tangent 2-bundle," analogous to the tangent bundle of a smooth manifold. Examples with reasonable finiteness conditions have an intrinsic geometry, which can approximate classical solutions to general relativity. We propose an approach to quantization of causal sites as well.Comment: 21 pages, 3 eps figures; v2: added references; to appear in JM

Solenoidal versus compressive turbulence forcing

We analyze the statistics and star formation rate obtained in high-resolution numerical experiments of forced supersonic turbulence, and compare with observations. We concentrate on a systematic comparison of solenoidal (divergence-free) and compressive (curl-free) forcing, which are two limiting cases of turbulence driving. Our results show that for the same RMS Mach number, compressive forcing produces a three times larger standard deviation of the density probability distribution. When self-gravity is included in the models, the star formation rate is more than one order of magnitude higher for compressive forcing than for solenoidal forcing.Comment: 1 page, to appear in the proceedings of the IAU General Assembly Joint Discussion 14 "FIR2009: The ISM of Galaxies in the Far-Infrared and Sub-Millimetre", ed. M. Cunningha

Introduction to Categories and Categorical Logic

The aim of these notes is to provide a succinct, accessible introduction to some of the basic ideas of category theory and categorical logic. The notes are based on a lecture course given at Oxford over the past few years. They contain numerous exercises, and hopefully will prove useful for self-study by those seeking a first introduction to the subject, with fairly minimal prerequisites. The coverage is by no means comprehensive, but should provide a good basis for further study; a guide to further reading is included. The main prerequisite is a basic familiarity with the elements of discrete mathematics: sets, relations and functions. An Appendix contains a summary of what we will need, and it may be useful to review this first. In addition, some prior exposure to abstract algebra - vector spaces and linear maps, or groups and group homomorphisms - would be helpful.Comment: 96 page