Applying static code analysis for domain-specific languages

The use of code quality control platforms for analysing source code is increasingly gaining attention in the developer community. These platforms are prepared to parse and check source code written in a variety of general-purpose programming languages. The emergence of domain-specific languages enables professionals from different areas to develop and describe problem solutions in their disciplines. Thus, source code quality analysis methods and tools can also be applied to software artefacts developed with a domain-specific language. To evaluate the quality of domain-specific language code, every software component required by the quality platform to parse and query the source code must be developed. This becomes a time-consuming and error-prone task, for which this paper describes a model-driven interoperability strategy that bridges the gap between the grammar formats of source code quality parsers and domain-specific text languages. This approach has been tested on the most widespread platforms for designing text-based languages and source code analysis. This interoperability approach has been evaluated on a number of specific contexts in different domain areas

A Comprehensive Framework to Reinforce Evidence Synthesis Features in Cloud-Based Systematic Review Tools

Systematic reviews are powerful methods used to determine the state-of-the-art in a given field from existing studies and literature. They are critical but time-consuming in research and decision making for various disciplines. When conducting a review, a large volume of data is usually generated from relevant studies. Computer-based tools are often used to manage such data and to support the systematic review process. This paper describes a comprehensive analysis to gather the required features of a systematic review tool, in order to support the complete evidence synthesis process. We propose a framework, elaborated by consulting experts in different knowledge areas, to evaluate significant features and thus reinforce existing tool capabilities. The framework will be used to enhance the currently available functionality of CloudSERA, a cloud-based systematic review tool focused on Computer Science, to implement evidence-based systematic review processes in other disciplines.This research was funded by the Spanish Research Agency (Agencia Estatal de Investigacion) with ERDF funds grant number TIN2017-85797-R (VISAIGLE project). The research stay of T. Person in the SFU was funded by Erasmus+ KA107 grant number 2017-1-ES01-KA107-037422. The APC was funded by the VISAIGLE project

Creacion visual de aplicaciones educativas para robótica e internet de las cosas basadas en dispositivos móviles

Este artículo presenta los principales aportes de dos investigaciones relacionadas con la autoría visual de escenarios educativos basados en dispositivos móviles, cuyos resultados fueron publicados en 2019 en revistas de impacto clasificadas en el primer cuartil del índice JCR. Se estudia la extensión de lenguajes visuales para incorporar soporte para robótica e Internet de las cosas como un mecanismo para facilitar el desarrollo de aplicaciones educativas que utilizan dispositivos móviles. Se realizaron varios talleres para crear actividades utilizando lenguajes textuales y visuales. Los resultados muestran como la aplicación de lenguajes visuales facilita y mejora el desarrollo de aplicaciones para participantes sin conocimientos previos de programación, así como para nuevos programadores.Trabajos financiados por la Agencia Estatal de Investigación del Ministerio de Ciencia e Innovación de España en el contexto del proyecto VISAIGLE (TIN2017-85797-R)

Nanostructured Ti thin films by magnetron sputtering at oblique angles

The growth of Ti thin films by the magnetron sputtering technique at oblique angles and at room temperature is analysed from both experimental and theoretical points of view. Unlike other materials deposited in similar conditions, the nanostructure development of the Ti layers exhibits an anomalous behaviour when varying both the angle of incidence of the deposition flux and the deposition pressure. At low pressures, a sharp transition from compact to isolated, vertically aligned, nanocolumns is obtained when the angle of incidence surpasses a critical threshold. Remarkably, this transition also occurs when solely increasing the deposition pressure under certain conditions. By the characterization of the Ti layers, the realization of fundamental experiments and the use of a simple growth model, we demonstrate that surface mobilization processes associated to a highly directed momentum distribution and the relatively high kinetic energy of sputtered atoms are responsible for this behaviourJunta de Andalucía P12-FQM- 2265Ministerio de Ciencia e Innovación CSD2008- 00023, MAT2013-42900-P, MAT2013-40852-R, MAT2014-59772-C2-1, MAT2011- 2908

Growth regimes of porous gold thin films deposited by magnetron sputtering at oblique incidence: from compact to columnar microstructures

Growth regimes of gold thin films deposited by magnetron sputtering at oblique angles and low temperatures are studied from both theoretical and experimental points of view. Thin films were deposited in a broad range of experimental conditions by varying the substrate tilt angle and background pressure, and were analyzed by Field Emission Scanning Electron Microscopy (FESEM) and Grazing Incidence Small-Angle X-ray Scattering (GISAXS) techniques. Results indicate that the morphological features of the films strongly depend on the experimental conditions, but can be categorized within four generic microstructures, each of them defined by different bulk geometrical patterns and pore percolation depth and connectivity. With the help of a growth model, a microstructure phase diagram has been constructed where the main features of the films are depicted as a function of experimentally controllable quantities, finding a good agreement with the experimental results in all the studied cases.Junta de Andalucía P09-CTS- 5189, TEP5283, P10-FQM-6900Comunidad de Madríd S2009/MAT–1726Ministerio de Economía y Competitividad MAT2011-29194-C02-01, CSD2008-00023, MAT2008-06652, MAT2010-21228, MAT2010-1844

Immunosuppression-independent role of regulatory T cells against hypertension-driven renal dysfunctions

Hypertension-associated cardiorenal diseases represent one of the heaviest burdens for current health systems. In addition to hemodynamic damage, recent results have revealed that hematopoietic cells contribute to the development of these diseases by generating proinflammatory and profibrotic environments in the heart and kidney. However, the cell subtypes involved remain poorly characterized. Here we report that CD39+ regulatory T (TREG) cells utilize an immunosuppression-independent mechanism to counteract renal and possibly cardiac damage during angiotensin II (AngII)-dependent hypertension. This mechanism relies on the direct apoptosis of tissue-resident neutrophils by the ecto-ATP diphosphohydrolase activity of CD39. In agreement with this, experimental and genetic alterations in TREG/TH cell ratios have a direct impact on tissue-resident neutrophil numbers, cardiomyocyte hypertrophy, cardiorenal fibrosis, and, to a lesser extent, arterial pressure elevation during AngII-driven hypertension. These results indicate that TREG cells constitute a first protective barrier against hypertension-driven tissue fibrosis and, in addition, suggest new therapeutic avenues to prevent hypertension-linked cardiorenal diseases.This work has been supported by grants from the Castilla-León Autonomous Government (CSI101U13), the Spanish Ministry of Economy and Competitiveness (SAF2012-31371, RD12/0036/0002), Worldwide Cancer Research, the Solórzano Foundation, and the Ramón Areces Foundation to X.R.B. P.M. is funded by the Spanish Ministry of Economy and Competitiveness (SAF2011-27330). S.F., M.M.-M., J.R.-V., and A.M.-M. were supported by the Spanish Ministry of Economy and Competitiveness through BES-2010-031386, CSIC JAE-Doc, Juan de la Cierva, and BES-2009-016103 contracts, respectively. Spanish government-sponsored funding to X.R.B. is partially supported by the European Regional Development Fund.Peer Reviewe

Gestión de exámenes online. Base de datos de preguntas y desarrollo de software

Depto. de Farmacología y ToxicologíaFac. de MedicinaFALSEsubmitte

Base de datos de preguntas y actualización del software. Herramientas para la generación de exámenes presenciales u online

Depto. de Farmacología y ToxicologíaFac. de MedicinaFALSEsubmitte

Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry

Aim To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers (NHCW). Methods Observational cohort study based on the SEMI-COVID-19 Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 in Spain. Patients aged 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality. Results As of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age of HCW was 52 (15) years and 62.4% were women. Prevalence of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p = 0.024 and 0.7% vs. 4.8%; p<0.001 respectively). Age, male sex and comorbidity, were independently associated with higher in-hospital mortality and healthcare working with lower mortality (OR 0.211, 95%CI 0.067-0.667, p = 0.008). 30-days survival was higher in HCW (0.968 vs. 0.851 p<0.001). Conclusions Hospitalized COVID-19 HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 in HCW does not carry more clinical severity nor mortality