Bond graph based sensitivity and uncertainty analysis modelling for micro-scale multiphysics robust engineering design

Components within micro-scale engineering systems are often at the limits of commercial miniaturization and this can cause unexpected behavior and variation in performance. As such, modelling and analysis of system robustness plays an important role in product development. Here schematic bond graphs are used as a front end in a sensitivity analysis based strategy for modelling robustness in multiphysics micro-scale engineering systems. As an example, the analysis is applied to a behind-the-ear (BTE) hearing aid. By using bond graphs to model power flow through components within different physical domains of the hearing aid, a set of differential equations to describe the system dynamics is collated. Based on these equations, sensitivity analysis calculations are used to approximately model the nature and the sources of output uncertainty during system operation. These calculations represent a robustness evaluation of the current hearing aid design and offer a means of identifying potential for improved designs of multiphysics systems by way of key parameter identification

Experimental and bond graph based sensitivity calculations for micro-scale robust engineering design

Copyright @ 2005 IEEEBond graph modeling and sensitivity analysis are used to provide a platform for the robust design of a small mechatronic device, a behind-the-ear (BTE) hearing aid. Two key components of the device, namely the telecoil and the receiver, are considered. Experimental measurements, bond graph simulation models and analytic sensitivity analysis are used to investigate the interaction between these components in order to gain insight into the effect of component placement on the robustness of the final product

Determination of Chlorinated organic compounds in aqueous matrices

Thirteen pure volatile, semi-volatile and non-volatile chlorinated organic compounds of molecular weights ranging from trichloroethylene (MW = 131.39 g mole -¹) to hexachlorobenzene (MW = 284.78 g mole-¹) were determined in aqueous matrices by GC-ECD. After 10% salt addition, different extraction tests were performed using fibres whose adsorbing phase was based on microsphere carbon particles characterized by a constant size. Five experimental parameters were optimized: extraction temperature and time, position of the fibre in the GC injector port, desorption temperature and time. The optimized analytical protocol was employed to determine the efficiency of a real activated carbon adsorption plant to remove organic chlorinated pollutants from an industrial wastewater at ng l-¹ levels

Is cardiac surgery warranted in children with Down syndrome? A case-controlled review

No Abstract. South African Medical Journal Vol. 96(9) (Part 2) 2006: 924-93

SUSY dark matter(s)

We review here the status of different dark matter candidates in the context of supersymmetric models, in particular the neutralino as a realization of the WIMP-mechanism and the gravitino. We give a summary of the recent bounds in direct and indirect detection and also of the LHC searches relevant for the dark matter question. We discuss also the implications of the Higgs discovery for the supersymmetric dark matter models and give the prospects for the future years.Comment: 16 pages, 3 figure

Serum levels of matrix metalloproteinases-2 and-9 and their tissue inhibitors in inflammatory neuromuscular disorders

We monitored serum levels of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) before and during intravenously applied immunoglobulin (IVIG) therapy in 33 patients with chronic immune-mediated neuropathies and myopathies and 15 controls. Baseline MMP-2 and TIMP-2 serum levels were lower and MMP-9 and TIMP-1 serum levels higher in all patients compared to age-matched controls. Eight days after IVIG treatment, MMP-2, TIMP-2, and TIMP-1 serum levels increased, while MMP-9 serum levels decreased, indicating tissue repair. After 60 days, MMP-9 levels increased, MMP-2 approached normal levels, while TIMP-1 and TIMP-2 serum levels were below day 8 levels, indicating relapsing tissue damage. Comparing the MMP/TIMP results with the clinical courses, IVIG treatment tended to change MMP/TIMP levels in a way that paralleled clinical improvement and relapse. In sum, during a distinct time period, IVIG therapy seems to be able to modulate VIMP-mediated tissue repair. Copyright (c) 2006 S. Karger AG, Basel

Beyond reporting statistical significance: Identifying informative effect sizes to improve scientific communication.

Transparent communication of research is key to foster understanding within and beyond the scientific community. An increased focus on reporting effect sizes in addition to p value-based significance statements or Bayes Factors may improve scientific communication with the general public. Across three studies ( N = 652), we compared subjective informativeness ratings for five effect sizes, Bayes Factor, and commonly used significance statements. Results showed that Cohen's U3 was rated as most informative. For example, 440 participants (69%) found U3 more informative than Cohen's d, while 95 (15%) found d more informative than U3, with 99 participants (16%) finding both effect sizes equally informative. This effect was not moderated by level of education. We therefore suggest that in general, Cohen's U3 is used when scientific findings are communicated. However, the choice of the effect size may vary depending on what a researcher wants to highlight (e.g. differences or similarities)