15,125 research outputs found
A rice ABC transporter, OsABCC1, reduces arsenic accumulation in the grain
Arsenic (As) is a chronic poison that causes severe skin lesions and cancer. Rice (Oryza sativa L.) is a major dietary source of As; therefore, reducing As accumulation in the rice grain and thereby diminishing the amount of As that enters the food chain is of critical importance. Here, we report that a member of the Oryza sativa C-type ATP-binding cassette (ABC) transporter (OsABCC) family, OsABCC1, is involved in the detoxification and reduction of As in rice grains. We found that OsABCC1 was expressed in many organs, including the roots, leaves, nodes, peduncle, and rachis. Expression was not affected when plants were exposed to low levels of As but was up-regulated in response to high levels of As. In both the basal nodes and upper nodes, which are connected to the panicle, OsABCC1 was localized to the phloem region of vascular bundles. Furthermore, OsABCC1 was localized to the tonoplast and conferred phytochelatin-dependent As resistance in yeast. Knockout of OsABCC1 in rice resulted in decreased tolerance to As, but did not affect cadmium toxicity. At the reproductive growth stage, the As content was higher in the nodes and in other tissues of wild-type rice than in those of OsABCC1 knockout mutants, but was significantly lower in the grain. Taken together, our results indicate that OsABCC1 limits As transport to the grains by sequestering As in the vacuoles of the phloem companion cells of the nodes in rice.open117318Ysciescopu
Finite SU(N)^k Unification
We consider N=1 supersymmetric gauge theories based on the group SU(N)_1 x
SU(N)_2 x ... x SU(N)_k with matter content (N,N*,1,...,1) + (1,N,N*,...,1) +
>... + (N*,1,1,...,N) as candidates for the unification symmetry of all
particles. In particular we examine to which extent such theories can become
finite and we find that a necessary condition is that there should be exactly
three families. We discuss further some phenomenological issues related to the
cases (N,k) = (3,3), (3,4), and (4,3), in an attempt to choose those theories
that can become also realistic. Thus we are naturally led to consider the
SU(3)^3 model which we first promote to an all-loop finite theory and then we
study its additional predictions concerning the top quark mass, Higgs mass and
supersymmetric spectrum.Comment: 15 page
Chinese Herbal Medicine Xingnaojing Injection for Ischemic Stroke:An Overview of Systematic Reviews and Meta-analyses
Background: Xingnaojing injection (XNJ) is the only Chinese herbal injection approved for both intracerebral hemorrhage and ischemia stroke (IS) first aid on ambulances in China, many systematic reviews (SRs) and meta-analysis (MAs) of XNJ on stroke has been published. The purpose of this research was to evaluate and summarize the current evidence on XNJ for IS. Methods: A comprehensive search was conducted for SRs and MAs of XNJ on IS in 7 databases up to January 1st 2021. Two authors independently identified SRs and MAs, extracted data, assessed the quality of included SRs and MAs using the Assessment of Multiple Systematic Reviews 2 (AMSTAR 2) and assessed quality of evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE). Results: A total of 10 SRs met the inclusion criteria. The quality of included SRs using AMSTAR 2 were critically low as the critical items were poorly reported. Only 10% of SRs reported 50% of the 16 items, while the remaining 90% SRs reported just less than half of items on AMSTAR 2. For GRADE, 7 (35%) of outcomes had low quality evidence, 10 (50%) with very low and 3 (15%) with moderate quality evidence. Very low to low quality of evidence indicated XNJ plus conventional therapy (CT) alleviated the neurological deficit of acute IS. Moderate quality evidence showed XNJ plus CT reduced mortality when compared to Danshen injection plus CT and very low quality evidence showed XNJ plus CT could not improve the degree of comma while low quality evidence indicated the opposite. Mild adverse events in CT group were less than that in XNJ plus CT group and there were no serious adverse events, but there was no statistical difference between the two groups. The included 10 SRs indicated that XNJ were used for acute IS, but only 4 SRs (40%) reported the course of disease. Conclusion: XNJ appears to be effective and safe for acute IS in improving the neurological deficits, but the evidence is not robust enough. However, whether administering XNJ immediately after or within 24 hours of IS is unknown due to lack of data. Well-designed large scale RCTs with measurable outcomes are required in future studies
Tracing magnetism and pairing in FeTe-based systems
In order to examine the interplay between magnetism and superconductivity, we
monitor the non- superconducting chalcogenide FeTe and follow its transitions
under insertion of oxygen, doping with Se and vacancies of Fe using
spin-polarized band structure methods (LSDA with GGA) starting from the
collinear and bicollinear magnetic arrangements. We use a supercell of Fe8Te8
as our starting point so that it can capture local changes in magnetic moments.
The calculated values of magnetic moments agree well with available
experimental data while oxygen insertions lead to significant changes in the
bicollinear or collinear magnetic moments. The total energies of these systems
indicate that the collinear-derived structure is the more favorable one prior
to a possible superconducting transition. Using a 8-site Betts-cluster-based
lattice and the Hubbard model, we show why this structure favors electron or
hole pairing and provides clues to a common understanding of charge and spin
pairing in the cuprates, pnictides and chalcogenides
Extreme Food-Plant Specialisation in Megabombus Bumblebees as a Product of Long Tongues Combined with Short Nesting Seasons
© 2015 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. http://creativecommons.org/licenses/by/4.0/ The attached file is the published version of the article
Mapping the optimal route between two quantum states
A central feature of quantum mechanics is that a measurement is intrinsically
probabilistic. As a result, continuously monitoring a quantum system will
randomly perturb its natural unitary evolution. The ability to control a
quantum system in the presence of these fluctuations is of increasing
importance in quantum information processing and finds application in fields
ranging from nuclear magnetic resonance to chemical synthesis. A detailed
understanding of this stochastic evolution is essential for the development of
optimized control methods. Here we reconstruct the individual quantum
trajectories of a superconducting circuit that evolves in competition between
continuous weak measurement and driven unitary evolution. By tracking
individual trajectories that evolve between an arbitrary choice of initial and
final states we can deduce the most probable path through quantum state space.
These pre- and post-selected quantum trajectories also reveal the optimal
detector signal in the form of a smooth time-continuous function that connects
the desired boundary conditions. Our investigation reveals the rich interplay
between measurement dynamics, typically associated with wave function collapse,
and unitary evolution of the quantum state as described by the Schrodinger
equation. These results and the underlying theory, based on a principle of
least action, reveal the optimal route from initial to final states, and may
enable new quantum control methods for state steering and information
processing.Comment: 12 pages, 9 figure
Feller Processes: The Next Generation in Modeling. Brownian Motion, L\'evy Processes and Beyond
We present a simple construction method for Feller processes and a framework
for the generation of sample paths of Feller processes. The construction is
based on state space dependent mixing of L\'evy processes.
Brownian Motion is one of the most frequently used continuous time Markov
processes in applications. In recent years also L\'evy processes, of which
Brownian Motion is a special case, have become increasingly popular.
L\'evy processes are spatially homogeneous, but empirical data often suggest
the use of spatially inhomogeneous processes. Thus it seems necessary to go to
the next level of generalization: Feller processes. These include L\'evy
processes and in particular Brownian motion as special cases but allow spatial
inhomogeneities.
Many properties of Feller processes are known, but proving the very existence
is, in general, very technical. Moreover, an applicable framework for the
generation of sample paths of a Feller process was missing. We explain, with
practitioners in mind, how to overcome both of these obstacles. In particular
our simulation technique allows to apply Monte Carlo methods to Feller
processes.Comment: 22 pages, including 4 figures and 8 pages of source code for the
generation of sample paths of Feller processe
Increased HIV Incidence in Men Who Have Sex with Men Despite High Levels of ART-Induced Viral Suppression: Analysis of an Extensively Documented Epidemic
Background: There is interest in expanding ART to prevent HIV transmission, but in the group with the highest levels of ART use, men-who-have-sex-with-men (MSM), numbers of new infections diagnosed each year have not decreased as ART coverage has increased for reasons which remain unclear.
Methods: We analysed data on the HIV-epidemic in MSM in the UK from a range of sources using an individual-based simulation model. Model runs using parameter sets found to result in good model fit were used to infer changes in HIV-incidence and risk behaviour.
Results: HIV-incidence has increased (estimated mean incidence 0.30/100 person-years 1990–1997, 0.45/100 py 1998–2010), associated with a modest (26%) rise in condomless sex. We also explored counter-factual scenarios: had ART not been introduced, but the rise in condomless sex had still occurred, then incidence 2006–2010 was 68% higher; a policy of ART initiation in all diagnosed with HIV from 2001 resulted in 32% lower incidence; had levels of HIV testing been higher (68% tested/year instead of 25%) incidence was 25% lower; a combination of higher testing and ART at diagnosis resulted in 62% lower incidence; cessation of all condom use in 2000 resulted in a 424% increase in incidence. In 2010, we estimate that undiagnosed men, the majority in primary infection, accounted for 82% of new infections.
Conclusion: A rise in HIV-incidence has occurred in MSM in the UK despite an only modest increase in levels of condomless sex and high coverage of ART. ART has almost certainly exerted a limiting effect on incidence. Much higher rates of HIV testing combined with initiation of ART at diagnosis would be likely to lead to substantial reductions in HIV incidence. Increased condom use should be promoted to avoid the erosion of the benefits of ART and to prevent other serious sexually transmitted infections
Geodesic motion in the space-time of a cosmic string
We study the geodesic equation in the space-time of an Abelian-Higgs string
and discuss the motion of massless and massive test particles. The geodesics
can be classified according to the particles energy, angular momentum and
linear momentum along the string axis. We observe that bound orbits of massive
particles are only possible if the Higgs boson mass is smaller than the gauge
boson mass, while massless particles always move on escape orbits. Moreover,
neither massive nor massless particles can ever reach the string axis for
non-vanishing angular momentum. We also discuss the dependence of light
deflection by a cosmic string as well as the perihelion shift of bound orbits
of massive particles on the ratio between Higgs and gauge boson mass and the
ratio between symmetry breaking scale and Planck mass, respectively.Comment: 20 pages including 14 figures; v2: references added, discussion on
null geodesics extended, numerical results adde
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