Thermal stress comfort in a contemporary housing district in a moderate climate zone, Lublin as a case study

Urban climate and its impact on the thermal comfort of residents are significant aspects in urban planning and the design of housing estates. The aim of this article is to investigate the temperature perception among residents in a contemporary residential area in Lublin during the hottest day, utilising an advanced computer simulation tool – the ENVI-met programme. A modern, densely built housing estate with no significant greenery was selected as a case study. General meteorological and spatial data were used for calibrating the housing estate model within the software. The housing estate model within the programme was calibrated using publicly available meteorological and spatial data, and computer simulations were conducted for Lublin's hottest day on 22 July 2022. Based on these simulations, the Universal Thermal Climate Index (UTCI) was calculated. The research results indicate that people experience moderate thermal stress in unshaded areas only at 4:00 pm, while in sunny locations, they experience strong to very strong heat stress throughout the day. This article underscores the importance of computer simulations in analysing the urban microclimate and provides insights into tools that can be used in urban planning and housing estate design processes, with the aim of creating more comfortable and environmentally friendly urban environments

Bilateral preventive mastectomy as a preventive method of breast cancer in the opinion of women

Background Breast cancer is the most common cancer among women. Despite of the progress of medicine and develop of treatment, it is still the second couse of death among women. To reduce the risk of getting breast cancer, the more ofen teratement is "preventive mastectomies" which completely remove the breast gland by healty women that are in the "high risk" group. Material and Methods To conduct the research I develop a survey, written by my own. The study included 252 women from Poland over the age of 18. Results The opinion about the performance of preventive mastectomies in case of women in "high risk" was very diverse. Only 13% of interviewees were convinced that they would have the surgery and up to 29% could not give an answer. Most woman (86%) are convinced that breast cancer is genetically determined. That mastectomy can be a way to prevent breast cancer agrees 69% of respondents. More than half of respondents (52%) don't know if such surgery is in Poland available. Only half of the respondents could indicate the place where an examination of an increased risk of breast cancer can be made (49%). 81% of respondents examine there breasts at least with one method, and 19% did not check it at all. Conclusions The knowledge about the heredity of cancer and the availability of treatments is insufficient. Women are not convinced that they would have gone to radical preventive treatment, and they are afraid of many consequences connected with it. It is essential to educate the public including the medical stuff in this scope. It is also important that the patient together with his doctor examined all the possible options for limiting the risk of cancer

Analysis of eating behavior of health science students in terms of emotional eating and restrained eating

Background. Two eating phenomena are associated with emotions and chronic stress: restrained eating and emotional eating. Restrained eating is defined as restricting food intake to control weight and mainly refers to the amount of food eaten. Emotional eating, on the other hand, focuses on eating in response to negative emotions. the literature emphasizes that people with orthorexia have significantly higher levels of stress, depression, and anxiety and lower life satisfaction than healthy individuals. Objective. The purpose of the conducted research was to assess the prevalence of emotionally driven eating behavior and restrained eating among health science students. The premise of the study was also to test whether there was a significant relationship between emotional eating and restrained eating and orthorectic behavior. Material and methods. The study was conducted among 200 randomly selected students of health sciences (dietetics and physical education). The TFEQ-13 and DOS scales were used in the study. Results and conclusions. Based on the study, it was concluded that there is no relationship between the occurrence of emotional eating and orthorexia in the studied group of people associated with health sciences. However, the hypothesis of the existence of these associations between restrained eating and the occurrence of orthorexia was supported. The group of restrained eaters was shown to include individuals with severe behaviors indicative of orthorexic tendencies or a full picture of the disorder

Natriuretic peptides and their usefulness in clinical practise

Natriuretic peptides are peptic hormones produced by atrial and ventricular myocytes, and by endothelium of blood vessels, that take part in homeostatic control of water and sodium levels, but also potassium transport, lipolysis in adipocytes and blood pressure regulation.   Three different natriuretic peptides are distinguished: atrial natriuretic peptide (ANP), b-type natriuretic peptide (BNP) and c-type natriuretic peptide (CNP). Those peptides are responsible mostly for water-sodium homeostasis and regulation of blood pressure. Levels of natriuretic peptides increase significantly in diseases and disorders such as congestive heart failure and pulmonary hypertension, that is why natriuretic peptides were found useful in diagnosis and monitoring of said diseases. In clinical practise, BNP and NT-proBNP levels are mostly used.  

75-year-old man with lung cancer obscured by an implantable cardioverter-defibrillator — case report

We present a case of a 75-year-old man, who underwent a scheduled implantable cardioverter-defibrillatorreoperation and has had a lung cancer found in a chest X-ray taken after the procedure, that wascompletely obscured by the previous device

E-cigarettes, is this alternative safe?

Electronic cigarettes are often presented as a safer alternative to classic cigarettes. We present an overview of the latest data on the safety of using e-cigarettes and their impact on the respiratory and cardiovascular systems. The statement that e-cigarettes are much less harmful seems too hasty due to the relatively short presence of e-cigarettes on the market. We need more years of research on large groups of patients to help us answer the question whether e-cigarettes are a better and safer form of smoking

Changes in inflammatory biomarkers after successful lifestyle intervention in obese children

Background: Obesity has been associated with low-grade systemic inflammation, potentially leading to insulin resistance, type 2 diabetes, dyslipidemia, and cardiovascular diseases. Even moderate weight loss through dietary changes and physical exercise is effective in preventing and managing obesity-associated disorders. The aim of this study was to determine the effect of weight loss in response to a lifestyle modification on the serum levels of inflammatory markers in obese children and adolescents. Material and methods: Fifty obese subjects completed a six-month programme consisting of combined hypocaloric diet and moderate physical activity. High-sensitive C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen (FB), white blood count (WBC), glucose, insulin, insulin resistance index (HOMA IR), glycosylated haemoglobin (HbA1c), lipids as well as systolic (SBP) and diastolic blood pressure (DBP) were measured before and after intervention. Results: Patients had a 5.3 ± 3.4 kg average weight loss, with significant decreases of SDS-BMI, percentage of body fat, SDS-waist, SBP and DBP, HOMA-IR, HbA1c and reductions in serum IL-6, CRP, WBC, FB. In the multivariable linear models, changes in percentage of body fat and HOMA-IR were positively associated with favourable changes in inflammatory parameters. Conclusion: This study demonstrates that weight reduction after successful lifestyle intervention results in improvements of blood inflammatory markers in obese children and adolescents. (Pol J Endocrinol 2011; 62 (6): 499–505)Wstęp: Otyłość wiąże się z obecnością niewielkiego stopnia stanu zapalnego, potencjalnie prowadzącego do insulinooporności, cukrzycy typu 2, dyslipidemii i chorób sercowo-naczyniowych. Nawet umiarkowane obniżenie masy ciała dzięki zmianie diety i zwiększonej aktywności fizycznej zapobiega występowaniu zaburzeń związanych z otyłością. Celem pracy była ocena wpływu obniżenia masy ciała (w wyniku modyfikacji stylu życia) na stężenie wskaźników stanu zapalnego w surowicy otyłych dzieci i młodzieży. Materiał i metody: W 6-miesięcznym programie polegającym na stosowaniu ubogokalorycznej diety i umiarkowanej aktywności fizycznej uczestniczyło 50 otyłych pacjentów. W warunkach podstawowych i po 6 miesiącach oznaczano: białko C-reaktywne (CRP), interleukinę 6 (IL-6), fibrynogen (FB), leukocyty (WBC), glukozę, insulinę, wskaźnik insulinooporności (HOMA-IR), hemoglobinę glikozylową (HbA1c), lipidy, ciśnienie tętnicze krwi skurczowe (SBD) i rozkurczowe (DBD). Wyniki: Średni spadek masy ciała u pacjentów wynosił 5,3 ± 3,4 kg, ze znaczącą redukcją wartości SDS-BMI, procentowej zawartości tłuszczu, SDS-obwodu pasa, SBP i DBP, HOMA-IR, HbA1c oraz obniżeniem stężeń IL-6, CRP, WBC, FB w surowicy. W wieloczynnikowej analizie regresji zmiany w procentowej zawartości tłuszczu i HOMA-IR były pozytywnie skorelowane z podobnymi zmianami wskaźników stanu zapalnego. Wnioski: Redukcja masy ciała w efekcie zmiany stylu życia wpływa na poprawę wskaźników stanu zapalnego u otyłych dzieci i młodzieży. (Endokrynol Pol 2011; 62 (6): 499–505

Stężenie 25-hydroksywitaminy D (25-OH-D) u otyłych nastolatków

Background: There is increasing evidence that vitamin D deficiency is common and has been associated with several non-bone related outcomes, including insulin resistance, type 2 diabetes and cardiovascular disease. The influences of gender, puberty, and adiposity on serum hydroxyvitamin D (25-OH-D) levels and the relationship between 25-OH-D and insulin resistance in obese children were studied. Material and methods: Age, gender, pubertal stage, weight status (standard deviation score of body mass index: BMI-SDS, percentage body fat, waist circumference), 25-OH-D levels, and insulin resistance index calculated by homeostasis model assessment (HOMA-IR) were evaluated in 64 obese adolescents. Multivariable linear regression was used to determine factors associated with decreased serum 25-OH-D levels and to study the relationship between 25-OH-D and HOMA-IR. Results: Median serum 25-OH-D level was 10.1 ng/mL (25.2 nmol/L). 14% of patients were vitamin D-sufficient (25-OH-D ≥ 20 ng/mL), 36% had intermediate values (11–19 ng/mL), and 50% were deficient (25-OH-D ≤ 10 ng/mL). In the multivariable model, older age, puberty, higher value of percentage of body fat, and the presence of acanthosis nigricans (AN) were all negatively associated with 25-OH-D. Lower 25-OH-D levels were also associated with higher blood glucose, insulin and HOMA-IR after adjustment for puberty and SDS-BMI. Summer positively correlated with 25-OH-D level. Conclusion: Our study confirms that obesity is a risk factor for vitamin D deficiency. Hypovitaminosis D, common in obese adolescents at risk for type 2 diabetes (older age, puberty, acanthosis nigricans) is associated with worse insulin resistance. (Pol J Endocrinol 2011; 62 (6): 506–511)Wstęp: Niedobór witaminy D jest zjawiskiem coraz bardziej powszechnym i związanym nie tylko z zaburzeniami metabolizmu kostnego, ale też z insulinoopornością, cukrzycą typu 2 i chorobami sercowo-naczyniowymi. Celem pracy było badanie wpływu płci, stadium pokwitania i otyłości na stężenie 25-OH-D w surowicy oraz zależności między witaminą D a insulinoopornością u otyłych dzieci. Materiał i metody: U 64 otyłych nastolatków oceniano wiek, płeć, stadium pokwitania, stopień otyłości i wskaźnik insulinooporności (HOMA-IR). Do określenia czynników wpływających na obniżenie stężenia 25-OH-D w surowicy oraz do oceny zależności między 25-OH-D a HOMA-IR wykorzystano wielowymiarową analizę regresji. Wyniki: Mediana stężenia 25-OH-D w surowicy wynosiła 10,1 ng/mL (25,2 mmol/L). Tylko u 14% pacjentów stężenie 25-OH-D w surowicy było wystarczające (≥ 20 ng/mL), u 36% wartości te wynosiły 11–19 ng/mL, u 50% stwierdzono znaczny niedobór 25-OH-D (≤ 10 ng/mL). W wielowymiarowej analizie regresji starszy wiek, bardziej zaawansowane stadium pokwitania, większy odsetek zawartości tłuszczu i obecność rogowacenia ciemnego korelowały negatywnie ze stężeniem witaminy D. Niższe stężenia 25-OH-D wiązały się z wyższym stężeniem glukozy, insuliny i HOMA-IR przy uwzględnieniu stadium pokwitania i SDS-BMI. Okres letni pozytywnie korelował ze stężeniem 25-OH-D. Wnioski: Otyłość jest czynnikiem ryzyka niedoboru witaminy D. Niedobór witaminy D powszechny u otyłych nastolatków zagrożonych cukrzycą typu 2 wiąże się z większą insulinoopornością. (Endokrynol Pol 2011; 62 (6): 506–511

Influence of cardiac resynchronization therapy on oxidative stress markers in patients with chronic heart failure

Background: The aim of the study was to assess changes of substances of oxidative stress in patients treated with cardiac resynchronization therapy (CRT).Methods: The study comprised 51 patients with median age of 66 years. The presence, severity, and changes of oxidative stress during CRT were assessed and expressed as malondialdehyde (MDA) concentration in plasma or in red blood cells. Antioxidant activity was assessed by the activity of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) in red blood cells. The concentration and activities were analyzed directly prior to implantation, 2–5 days after the procedure and after 6 months. Follow-up (6 months) included clinical, echocardiographic and implanted device assessments.Results: During the follow-up, 14% patients died. The median percentage of biventricular pacing was 99.29%. After 6 months 88% of patients improved NYHA, 12% remained as non-responders. Left ventricular ejection fraction increased from median 21.5% to 29% (p < 0.05). Left ventricular end-diastolic diameter decreased significantly from a median of 69.5 mm to 63 mm (p < 0.05). After a 6-month study, MDA plasma concentration and the activity levels of each antioxidant enzymes (CAT, SOD, GPx) showed a statistically significant reduction (p < 0.05). Changes concerning MDA concentrations in red blood cells remained statistically insignificant.Conclusions: Resynchronization effect oxidative stress by reducing plasma concentration of MDA, CAT, SOD and GPX

Consumer Experience of Foreign Products in China: The Role of Digital Media

Digital media are relevant touch points that contribute to shape the customer journey and allow consumers to engage more with firms. In particular, they play a primary role in the largest web-user base in the world, China. Internet also represents an increasing channel for Chinese consumers to purchase any type of products, including foreign brands. In this market, the main Internet access point is represented by mobile phones. This has led firms to substantially increase their expenditure in mobile advertising and e-commerce platforms’ implementation. This article aims at contributing to the recent marketing literature that conceptualize customer experience as a dynamic process by analyzing the customer journey in China related to foreign brands. A mixed method approach is adopted, consisting of focus groups and a preliminary questionnaire. Results show that digital media play a main role in the consumer journey of Chinese consumers, as information tool and increasing purchase channel