Gorlin syndrome associated with small bowel carcinoma and mesenchymal proliferation of the gastrointestinal tract: case report and review of literature

<p>Abstract</p> <p>Background and Case Presentation</p> <p>A patient with nevoid basal cell carcinoma syndrome (Gorlin syndrome) presented with two unusual clinical features, i.e. adenocarcinoma of the small bowel and extensive mesenchymal proliferation of the lower gastrointestinal tract.</p> <p>Conclusions</p> <p>We discuss the possibility that these two features are pathogenetically linked to the formerly undescribed patient's <it>PTCH </it>germ line mutation.</p

Extended Longevity of Reproductives Appears to be Common in Fukomys Mole-Rats (Rodentia, Bathyergidae)

African mole-rats (Bathyergidae, Rodentia) contain several social, cooperatively breeding species with low extrinsic mortality and unusually high longevity. All social bathyergids live in multigenerational families where reproduction is skewed towards a few breeding individuals. Most of their offspring remain as reproductively inactive “helpers” in their natal families, often for several years. This “reproductive subdivision” of mole-rat societies might be of interest for ageing research, as in at least one social bathyergid (Ansell's mole-rats Fukomys anselli), breeders have been shown to age significantly slower than non-breeders. These animals thus provide excellent conditions for studying the epigenetics of senescence by comparing divergent longevities within the same genotypes without the inescapable short-comings of inter-species comparisons. It has been claimed that many if not all social mole-rat species may have evolved similar ageing patterns, too. However, this remains unclear on account of the scarcity of reliable datasets on the subject. We therefore analyzed a 20-year breeding record of Giant mole-rats Fukomys mechowii, another social bathyergid species. We found that breeders indeed lived significantly longer than helpers (ca. 1.5–2.2fold depending on the sex), irrespective of social rank or other potentially confounding factors. Considering the phylogenetic positions of F. mechowii and F. anselli and unpublished data on a third Fukomys-species (F. damarensis) showing essentially the same pattern, it seems probable that the reversal of the classic trade-off between somatic maintenance and sexual reproduction is characteristic of the whole genus and hence of the vast majority of social mole-rats

Mask-Oriented Grouping Operations in a Contour-Based Approach

Maßmann A, Posch S. Mask-Oriented Grouping Operations in a Contour-Based Approach. In: Proc. 2nd Asian Conference on Computer Vision. Vol 3. Singapore: IEEE; 1995: 58-61.The goal of our investigation is a precise formulation of the Gestalt laws collinearity, curvilinearity, and proximity. Statistical results of hand labeled groupings are used to derive masks for the three different grouping operations, so called areas of "perceptual attentivness". These masks are applied to real images. Scaling according to the length of the individual contour segments assures a different size of the grouping and significantly reduces the complexity of grouping processes

Using Markov Random Fields for Contour-Based Grouping

Maßmann S, Sagerer G, Posch S. Using Markov Random Fields for Contour-Based Grouping. In: Proceedings International Conference on Image Processing. Vol 2. IEEE; 1997: 207-210.To overcome fragmentation of an initial contour-based segmentation and to organize contour segments into image primitives on a higher level of abstraction, regularities of the image data are exploited using ideas from the Gestalt psychology. First, groups are hypothesized within a hierarchy based on local evidence only, where the criteria are derived from a hand labelled training set. These hypotheses are subsequently judged in a global context using a Markov Random Field to derive a global interpretation. Examples of results for real data are given

Investigation of desaturation in an old tunnel and new galleries at an argillaceous site

A numerical investigation of the desaturation process at the argillaceous Tournemire site has been carried out. This desaturation is initialized by the contact of the saturated rock with the ambient air in excavated openings. The used hydraulical model is based on the Richards' approximation for unsaturated one phase flow coupled with the deformation of a porous medium with anisotropic linearly elastic behavior. In relation to the extent of the desaturated zone around an excavated opening, the intrinsic permeability and the relative permeability have been identified to be the most important model parameters. The mechanical deformation process itself, the seasonal influences and the tunnel lining are less important for the formation of the desaturated zone. The comparison with measured saturation values bares some difficulties but indicates the principle capacity of the applied finite element codes to simulate the desaturation process. The consideration of seasonal changes in humidity in the ambient air results in a constantly recurring desaturation-resaturation cycle in the near field of the openings. This seasonally influenced zone amount 1-2 m and is nearly independent from time and from a variation of model parameters within a reasonable range. The possibility of material weakening in this zone is of special interest, since claystone is a potential host rock for the disposal of radioactive waste. © 2008 Springer-Verlag

Study of the initiation and propagation of excavation damaged zones around openings in argillaceous rock

The study of the creation and evolution of the excavation disturbed zone (EDZ) in argillaceous rocks is a major issue for the safety of nuclear wastes underground repositories. In this context, the argillaceous Tournemire site has provided a unique opportunity to study the evolution of the EDZ with time thanks to the existence of three openings of different ages. A thorough characterization of the EDZ has been conducted by different means such as visual observation, analysis of samples extracted from drilled boreholes, EDZ permeability measurements, etc. On the basis of these measurements, a conceptual model of the EDZ initiation and propagation at the Tournemire site has been proposed. In order to validate this model, numerical simulations of increasing complexity have been carried out. In a first attempt, the response of the rock mass to the excavation phase, followed by seasonal cyclic variations of temperature and relative humidity inside the opening, has been simulated by means of a purely mechanical analysis, using a simple elastic material model. The EDZ has been estimated by post-processing the calculated stress states, using a Mohr-Coulomb failure criterion. The results obtained show that no EDZ could be predicted unless adopting a low cohesion value for the rock mass. Moreover, the deferred nature of the EDZ formation in Tournemire could not be reproduced. These limitations have then been suppressed by using a coupled viscoplastic-damaging mechanical model, the parameters of which have been identified from different laboratory experiments. With this model, a time evolution of the EDZ could be predicted, but the EDZ pattern could not match the one observed in situ. Finally, in view of the importance of the hydraulic couplings, unsaturated hydro-mechanical calculations have been carried out to investigate the effect of the numerous seasonal variations cycles and the resulting shrinkage. © 2008 Springer-Verlag

Bereiche perzeptiver Aufmerksamkeit für konturbasierte Gruppierung

Maßmann A, Posch S. Bereiche perzeptiver Aufmerksamkeit für konturbasierte Gruppierung. Informatik Aktuell. 1995:602-609