1,306 research outputs found
Global attractors for non-linear viscoelastic equation with strong damping
In this paper, we consider the long-time dynamical behavior of the viscoelastic equations with strong damping and further prove the existence of global attractors for this system
MRFalign: Protein Homology Detection through Alignment of Markov Random Fields
Sequence-based protein homology detection has been extensively studied and so
far the most sensitive method is based upon comparison of protein sequence
profiles, which are derived from multiple sequence alignment (MSA) of sequence
homologs in a protein family. A sequence profile is usually represented as a
position-specific scoring matrix (PSSM) or an HMM (Hidden Markov Model) and
accordingly PSSM-PSSM or HMM-HMM comparison is used for homolog detection. This
paper presents a new homology detection method MRFalign, consisting of three
key components: 1) a Markov Random Fields (MRF) representation of a protein
family; 2) a scoring function measuring similarity of two MRFs; and 3) an
efficient ADMM (Alternating Direction Method of Multipliers) algorithm aligning
two MRFs. Compared to HMM that can only model very short-range residue
correlation, MRFs can model long-range residue interaction pattern and thus,
encode information for the global 3D structure of a protein family.
Consequently, MRF-MRF comparison for remote homology detection shall be much
more sensitive than HMM-HMM or PSSM-PSSM comparison. Experiments confirm that
MRFalign outperforms several popular HMM or PSSM-based methods in terms of both
alignment accuracy and remote homology detection and that MRFalign works
particularly well for mainly beta proteins. For example, tested on the
benchmark SCOP40 (8353 proteins) for homology detection, PSSM-PSSM and HMM-HMM
succeed on 48% and 52% of proteins, respectively, at superfamily level, and on
15% and 27% of proteins, respectively, at fold level. In contrast, MRFalign
succeeds on 57.3% and 42.5% of proteins at superfamily and fold level,
respectively. This study implies that long-range residue interaction patterns
are very helpful for sequence-based homology detection. The software is
available for download at http://raptorx.uchicago.edu/download/.Comment: Accepted by both RECOMB 2014 and PLOS Computational Biolog
Exponential stability for a Timoshenko-type system with history
AbstractIn this paper, we consider hyperbolic Timoshenko-type vibrating systems that are coupled to a heat equation modeling an expectedly dissipative effect through heat conduction. We use the semigroup method to prove the exponential stability result with assumptions on past history relaxation function g exponentially decaying for the equal wave-speed case
Less but Better: Generalization Enhancement of Ordinal Embedding via Distributional Margin
In the absence of prior knowledge, ordinal embedding methods obtain new
representation for items in a low-dimensional Euclidean space via a set of
quadruple-wise comparisons. These ordinal comparisons often come from human
annotators, and sufficient comparisons induce the success of classical
approaches. However, collecting a large number of labeled data is known as a
hard task, and most of the existing work pay little attention to the
generalization ability with insufficient samples. Meanwhile, recent progress in
large margin theory discloses that rather than just maximizing the minimum
margin, both the margin mean and variance, which characterize the margin
distribution, are more crucial to the overall generalization performance. To
address the issue of insufficient training samples, we propose a margin
distribution learning paradigm for ordinal embedding, entitled Distributional
Margin based Ordinal Embedding (\textit{DMOE}). Precisely, we first define the
margin for ordinal embedding problem. Secondly, we formulate a concise
objective function which avoids maximizing margin mean and minimizing margin
variance directly but exhibits the similar effect. Moreover, an Augmented
Lagrange Multiplier based algorithm is customized to seek the optimal solution
of \textit{DMOE} effectively. Experimental studies on both simulated and
real-world datasets are provided to show the effectiveness of the proposed
algorithm.Comment: Accepted by AAAI 201
Zero frequency zonal flow excitation by energetic electron driven beta-induced Alfven eigenmode
Zero frequency zonal flow (ZFZF) excitation by trapped energetic electron
driven beta-induced Alfven eigenmode (eBAE) is investigated using nonlinear
gyrokinetic theory. It is found that, during the linear growth stage of eBAE,
resonant energetic electrons (EEs) not only effectively drive eBAE unstable,
but also contribute to the nonlinear coupling, leading to ZFZF excitation. The
trapped EE contribution to ZFZF generation is dominated by EE responses to eBAE
in the ideal region, and is comparable to thermal plasma contribution to
Reynolds and Maxwell stresses.Comment: submitted to Plasma Physics and Controlled Fusion (2020
Negative Magnetoresistance in Dirac Semimetal Cd3As2
A large negative magnetoresistance is anticipated in topological semimetals
in the parallel magnetic and electric field configuration as a consequence of
the nontrivial topological properties. The negative magnetoresistance is
believed to demonstrate the chiral anomaly, a long-sought high-energy physics
effect, in solid-state systems. Recent experiments reveal that Cd3As2, a Dirac
topological semimetal, has the record-high mobility and exhibits positive
linear magnetoresistance in the orthogonal magnetic and electric field
configuration. However, the negative magnetoresistance in the parallel magnetic
and electric field configuration remains unveiled. Here, we report the
observation of the negative magnetoresistance in Cd3As2 microribbons in the
parallel magnetic and electric field configuration as large as 66% at 50 K and
even visible at room temperatures. The observed negative magnetoresistance is
sensitive to the angle between magnetic and electrical field, robust against
temperature, and dependent on the carrier density. We have found that carrier
densities of our Cd3As2 samples obey an Arrhenius's law, decreasing from
3.0x10^17 cm^-3 at 300 K to 2.2x10^16 cm^-3 below 50 K. The low carrier
densities result in the large values of the negative magnetoresistance. We
therefore attribute the observed negative magnetoresistance to the chiral
anomaly. Furthermore, in the perpendicular magnetic and electric field
configuration a positive non-saturating linear magnetoresistance up to 1670% at
14 T and 2 K is also observed. This work demonstrates potential applications of
topological semimetals in magnetic devices
Organophosphate Ester Flame Retardants and Plasticizers in ocean sediments from the North Pacific to the Arctic Ocean
The occurence of organophosphate ester (OPE) flame retardants and plasticizers in surface sediment from the North Pacific to Arctic Ocean was observed for the first time during the fourth National Arctic Research Expedition of China in the summer of 2010. The samples were analyzed for three halogenated OPEs [tris(2-chloroethyl) phosphate (TCEP), tris(1-chloro-2-propyl) phosphate (TCPP), and tris(dichloroisopropyl) phosphate], three alkylated OPEs [triisobutyl phosphate (TiBP), tri-n-butyl phosphate, and tripentyl phosphate], and triphenyl phosphate. Σ7OPEs (total concentration of the observed OPEs) was in the range of 159–4658 pg/g of dry weight. Halogenated OPEs were generally more abundant than the nonhalogenated OPEs; TCEP and TiBP dominated the overall concentrations. Except for that of the Bering Sea, Σ7OPEs values increased with increasing latitudes from Bering Strait to the Central Arctic Ocean, while the contributions of halogenated OPEs (typically TCEP and TCPP) to the total OPE profile also increased from the Bering Strait to the Central Arctic Ocean, indicating they are more likely to be transported to the remote Arctic. The median budget of 52 (range of 17–292) tons for Σ7OPEs in sediment from the Central Arctic Ocean represents only a very small amount of their total production volume, yet the amount of OPEs in Arctic Ocean sediment was significantly larger than the sum of polybrominated diphenyl ethers (PBDEs) in the sediment, indicating they are equally prone to long-range transport away from source regions. Given the increasing level of production and usage of OPEs as substitutes of PBDEs, OPEs will continue to accumulate in the remote Arctic
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