Cloud Computing for University Laboratory Construction

Educational establishments continue to seek opportunities to rationalize the way they manage resources. cloud computing is to supply safe, quick, convenient data storage. It will make significant impacts in the construction of digital resources in college. This thesis firstly introduce its definition, theory of work and nature, and describe its applications at present, then analyze the problems that exist in the construction of information resources in college, finally study the applications of information resources construction in college in detail

Evaluation of Influence of Acupuncture and Electro-Acupuncture for Blood Perfusion of Stomach by Laser Doppler Blood Perfusion Imaging

The objective of this study is to observe effects of acupuncture and electro-acupuncture (EA) on blood perfusion in the stomach, and probe into the application of laser Doppler blood perfusion imaging technique in the study of the effect of acupuncture and moxibustion on the entrails. In the acupuncture group of 20 rats, acupuncture was given at “Zusanli” (ST 36) and in EA group of 18 rats, EA was applied at “Zusanli” (ST 36), with 18 rats without acupuncture used as control group. Changes of blood perfusion and microcirculation distribution in the stomach were investigated with laser Doppler blood perfusion imager (LDPI). The laser Doppler blood perfusion image could clearly display changes of blood flow distribution in the stomach before and after acupuncture. After acupuncture or EA was given at “Zusanli” (ST 36), the blood perfusion in the stomach increased significantly, the blood perfusion in the blood vessels and microcirculation of other parts significantly increased, and the maximum increase of the blood perfusion was found at 10 min after acupuncture or EA, with increases of 0.50 _ 0.11 (PU) and 0.66 _ 0.16 (PU), respectively, and the blood perfusion still kept at a higher degree within 10 min after ceasing of the acupuncture or EA. While the blood perfusion in the stomach in the rat of the control group tended to gradual decrease. It has been concluded that both acupuncture and EA can increase blood perfusion in the stomach, the EA having stronger action, and LDPI can display the regulative action of acupuncture on the blood vessel of the stomach by using an image

Crosstalk of nervous and immune systems in pancreatic cancer

Pancreatic cancer is a highly malignant tumor known for its extremely low survival rate. The combination of genetic disorders within pancreatic cells and the tumor microenvironment contributes to the emergence and progression of this devastating disease. Extensive research has shed light on the nature of the microenvironmental cells surrounding the pancreatic cancer, including peripheral nerves and immune cells. Peripheral nerves release neuropeptides that directly target pancreatic cancer cells in a paracrine manner, while immune cells play a crucial role in eliminating cancer cells that have not evaded the immune response. Recent studies have revealed the intricate interplay between the nervous and immune systems in homeostatic condition as well as in cancer development. In this review, we aim to summarize the function of nerves in pancreatic cancer, emphasizing the significance to investigate the neural-immune crosstalk during the advancement of this malignant cancer

Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling.

BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury. However, whether Hsp70 interacts with p38 MAPK signaling is unclear. Therefore, this study investigated the regulation of p38 MAPK by Hsp70 in I/R-induced cardiac injury.MethodsNeonatal rat cardiomyocytes were subjected to oxygen-glucose deprivation for 6 h followed by 2 h reoxygenation (OGD/R), and rats underwent left anterior artery ligation for 30 min followed by 30 min of reperfusion. The p38 MAPK inhibitor (SB203580), Hsp70 inhibitor (Quercetin), and Hsp70 short hairpin RNA (shRNA) were used prior to OGD/R or I/R. Cell viability, lactate dehydrogenase (LDH) release, serum cardiac troponin I (cTnI), [Ca2+]i levels, cell apoptosis, myocardial infarct size, mRNA level of IL-1β and IL-6, and protein expression of Hsp70, phosphorylated p38 MAPK (p-p38 MAPK), sarcoplasmic/endoplasmic reticulum Ca2+-ATPase2 (SERCA2), phosphorylated signal transducer and activator of transcription3 (p-STAT3), and cleaved caspase3 were assessed.ResultsPretreatment with a p38 MAPK inhibitor, SB203580, significantly attenuated OGD/R-induced cell injury or I/R-induced myocardial injury, as evidenced by improved cell viability and lower LDH release, resulted in lower serum cTnI and myocardial infarct size, alleviation of [Ca2+]i overload and cell apoptosis, inhibition of IL-1β and IL-6, and modulation of protein expressions of p-p38 MAPK, SERCA2, p-STAT3, and cleaved-caspase3. Knockdown of Hsp70 by shRNA exacerbated OGD/R-induced cell injury, which was effectively abolished by SB203580. Moreover, inhibition of Hsp70 by quercetin enhanced I/R-induced myocardial injury, while SB203580 pretreatment reversed the harmful effects caused by quercetin.ConclusionsInhibition of Hsp70 aggravates [Ca2+]i overload, inflammation, and apoptosis through regulating p38 MAPK signaling during cardiac I/R injury, which may help provide novel insight into cardioprotective strategies

Study on cosmogenic activation in copper for rare event search experiments

The rare event search experiments using germanium detectors are performed in the underground laboratories to prevent cosmic rays. However, the cosmogenic activation of the cupreous detector components on the ground will generate long half-life radioisotopes and contribute continually to the expected background level. We present a study on the cosmogenic activation of copper after 504 days of exposure at an altitude of 2469.4 m outside the China Jinping Underground Laboratory (CJPL). The specific activities of the cosmogenic nuclides produced in the copper bricks were measured using a low background germanium gamma-ray spectrometer at CJPL. The production rates at sea level, in units of nuclei/kg/day, are 18.6 \pm 2.0 for Mn-54, 9.9 \pm 1.3 for Co-56, 48.3 \pm 5.5 for Co-57, 51.8 \pm 2.5 for Co-58 and 39.7 \pm 5.7 for Co-60, respectively. Given the expected exposure history of the germanium detectors, a Monte Carlo simulation is conducted to assess the cosmogenic background contributions of the detectors' cupreous components.Comment: 6 pages, 4 figure

Structure Mediation and Properties of Poly(l-lactide)/Poly(d-lactide) Blend Fibers

Poly(l-lactic acid) (PLLA) and poly(d-lactic acid) (PDLA) blend as-spun fibers (50/50, wt.%) were prepared by melt spinning. Structure mediation under temperature and stress and properties of poly(l-lactic acid)/poly(d-lactic acid)(PLLA/PDLA) as-spun fibers were investigated by wide-angle X-ray scattering (WAXS) and differential scanning calorimetry (DSC). The results show that highly oriented stereocomplex (SC) crystals can be formed in PLLA/PDLA blend fibers drawn at 60 °C and annealed at 200 °C. However, at drawn temperature of 80 °C, only lower oriented SC crystals can be formed. For PLLA/PDLA blend fibers drawn twice at 60 °C (PLLA/PDLA-60-2), the crystallinity of SC crystals increases with annealing temperature in the range of 200 to 215 °C, while the degree of orientation decreases slightly. When the annealing temperature is 210 °C, the crystallinity and orientation of SC crystals in PLLA/PDLA-60-2 fibers reach 51% and −0.39, respectively. Moreover, PLLA/PDLA-60-2-210 fibers exhibit excellent heat-resistant property even at 200 °C. The results indicate that the oriented PLLA/PDLA blend fibers with high SC crystals content can be regulated in a short time

Metallic surface states in a correlated d-electron topological Kondo insulator candidate FeSb2

The resistance of a conventional insulator diverges as temperature approaches zero. The peculiar low temperature resistivity saturation in the 4f Kondo insulator (KI) SmB6 has spurred proposals of a correlation-driven topological Kondo insulator (TKI) with exotic ground states. However, the scarcity of model TKI material families leaves difficulties in disentangling key ingredients from irrelevant details. Here we use angle-resolved photoemission spectroscopy (ARPES) to study FeSb2, a correlated d-electron KI candidate that also exhibits a low temperature resistivity saturation. On the (010) surface, we find a rich assemblage of metallic states with two-dimensional dispersion. Measurements of the bulk band structure reveal band renormalization, a large temperature-dependent band shift, and flat spectral features along certain high symmetry directions, providing spectroscopic evidence for strong correlations. Our observations suggest that exotic insulating states resembling those in SmB6 and YbB12 may also exist in systems with d instead of f electrons