Effect of source tampering in the security of quantum cryptography

The security of source has become an increasingly important issue in quantum cryptography. Based on the framework of measurement-device-independent quantum-key-distribution (MDI-QKD), the source becomes the only region exploitable by a potential eavesdropper (Eve). Phase randomization is a cornerstone assumption in most discrete-variable (DV-) quantum communication protocols (e.g., QKD, quantum coin tossing, weak coherent state blind quantum computing, and so on), and the violation of such an assumption is thus fatal to the security of those protocols. In this paper, we show a simple quantum hacking strategy, with commercial and homemade pulsed lasers, by Eve that allows her to actively tamper with the source and violate such an assumption, without leaving a trace afterwards. Furthermore, our attack may also be valid for continuous-variable (CV-) QKD, which is another main class of QKD protocol, since, excepting the phase random assumption, other parameters (e.g., intensity) could also be changed, which directly determine the security of CV-QKD.Comment: 9 pages, 6 figure

Study on Complex Products Job-shop Scheduling System Based on MES

Various random disturbances that happen in the process of complex products (ship) production cannot feedback timely, and the plans of job-shop operation are too rough to instruct job-shop production. The purpose of this study is to solve the problems above, help the course of complex products (ship) job-shop production runs orderly and efficiently, and improve the job-shop on-site management level. In this paper, we proposed complex products job-shop scheduling system based on MES. The system adopts six-level, refined plan and scheduling mechanism. Its key part is the job-shop scheduling model with man-machine coordinated mechanism. What’s more, an improved Genetic Algorithm based on TOC is proposed to make the optimized algorithm module of the system more scientific and effective. Key words: Complex Products; MES; Job-shop Scheduling System; Man-machine Coordinated Mechanism; Genetic Algorithm Résumé: Diverses perturbations qui se produisent au hasard dans le processus de production des produits complexes (navire) ne peuvent pas être apperçues en temps opportun, et les plans de l'opération des ateliers sont trop approximatifs pour guider la production. Le but de cette étude consiste à résoudre les problèmes ci-dessus, rendre le cours de la production des produits complexes (ship) dans les ateliers ordonné et efficace et améliorer le niveau de gestion sur place. Dans cet article, nous avons proposé le système de planning des ateliers de produits complexes basé sur MES. Le système contient six niveaux de programmation raffinée et de mécanismes de planning. Son élément essentiel est le modèle de programmation avec les mécanismes de coordination homme-machine. De plus, un algorithme génétique amélioré basé sur TOC est également proposé de rendre le module de l'algorithme du système optimisé plus scientifique et efficace. Mots-clés: produits complexes; MES; système de planning des ateliers; mécanismes de coordination homme-machine; algorithme génétique 摘要：針對目前複雜產品（船舶）生產過程中所出現的各種隨機擾動不能得到及時回饋，以及車間作業計畫粗略難以直接指導車間生產的現狀，本文提出基於 MES的複雜產品車間作業調度系統。該系統採用逐層細化的五級計畫與調度機制，以人機協同的車間作業調度模型為核心，通過改進基於 TOC的遺傳演算法，使系統的演算法模組優化性能更具有科學性和操作性。該系統有助於實現複雜產品（船舶）車間生產過程的有序運作，從而提高生產車間的現場管理水準。 關鍵字：複雜產品； MES；車間作業調度；人機協同；遺傳演算

Isospin dependence of projectile-like fragment production at intermediate energies

The cross sections of fragments produced in 140 $A$ MeV $^{40,48}$Ca + $^9$Be and $^{58,64}$Ni + $^9$Be reactions are calculated by the statistical abration-ablation(SAA) model and compared to the experimental results measured at the National Superconducting Cyclotron Laboratory (NSCL) at Michigan State University. The fragment isotopic and isotonic cross section distributions of $^{40}$Ca and $^{48}$Ca, $^{58}$Ni and $^{64}$Ni, $^{40}$Ca and $^{58}$Ni, and $^{48}$Ca and $^{64}$Ni are compared and the isospin dependence of the projectile fragmentation is studied. It is found that the isospin dependence decreases and disappears in the central collisions. The shapes of the fragment isotopic and isotonic cross section distributions are found to be very similar for symmetric projectile nuclei. The shapes of the fragment isotopic and isotonic distributions of different asymmetric projectiles produced in peripheral reactions are found very similar. The similarity of the distributions are related to the similar proton and neutron density distributions inside the nucleus in framework of the SAA model.Comment: 7 pages, 4 figures; to be published in Phys Rev

Interferon-gamma inducible protein 10 (IP10) induced cisplatin resistance of HCC after liver transplantation through ER stress signaling pathway.

Tumor recurrence remains an obstacle after liver surgery, especially in living donor liver transplantation (LDLT) for patients with hepatocellular carcinoma (HCC). The acute-phase liver graft injury might potentially induce poor response to chemotherapy in recurrent HCC after liver transplantation. We here intended to explore the mechanism and to identify a therapeutic target to overcome such chemoresistance. The associations among graft injury, overexpression of IP10 and multidrug resistant genes were investigated in a rat liver transplantation model, and further validated in clinical cohort. The role of IP10 on HCC cell proliferation and tumor growth under chemotherapy was studied both in vitro and in vivo. The underlying mechanism was revealed by detecting the activation of endoplasmic reticulum (ER) stress signaling pathways. Moreover, the effect of IP10 neutralizing antibody sensitizing cisplatin treatment was further explored. In rat liver transplantation model, significant up-regulation of IP10 associated with multidrug resistant genes was found in small-for-size liver graft. Clinically, high expression of circulating IP10 was significant correlated with tumor recurrence in HCC patients underwent LDLT. Overexpression of IP10 promoted HCC cell proliferation and tumor growth under cisplatin treatment by activation of ATF6/Grp78 signaling. IP10 neutralizing antibody sensitized cisplatin treatment in nude mice. The overexpression of IP10, which induced by liver graft injury, may lead to cisplatin resistance via ATF6/Grp78 ER stress signaling pathway. IP10 neutralizing antibody could be a potential adjuvant therapy to sensitize cisplatin treatment