Sampling the Faraday rotation sky of TNG50: Imprint of the magnetised circumgalactic medium around Milky Way-like galaxies

Faraday rotation measure (RM) is arguably the most practical observational tracer of magnetic fields in the diffuse circumgalactic medium (CGM). We sample synthetic Faraday rotation skies of Milky Way-like galaxies in TNG50 of the IllustrisTNG project by placing an observer inside the galaxies at a solar circle-like position. Our synthetic RM grids emulate specifications of current and upcoming surveys; the NRAO VLA Sky Survey (NVSS), the Polarisation Sky Survey of the Universe's Magnetism (POSSUM), and a future Square Kilometre Array (SKA1-mid) polarisation survey. It has been suggested that magnetic fields regulate the survival of high-velocity clouds. However, there is only a small number of observational detections of magnetised clouds thus far. In the first part of the paper, we test conditions for the detection of magnetised circumgalactic clouds. Based on the synthetic RM samplings of clouds in the simulations, we predict upcoming polarimetric surveys will open opportunities for the detection of even low-mass and distant clouds. In the second part of the paper, we investigate the imprint of the CGM in the all-sky RM distribution. We test whether the RM variation produced by the CGM is correlated with global galaxy properties, such as distance to a satellite, specific star formation rate, neutral hydrogen covering fraction, and accretion rate to the supermassive black hole. We argue that the observed fluctuation in the RM measurements on scales less than 1 degree, which has been considered an indication of intergalactic magnetic fields, might in fact incorporate a significant contribution of the Milky Way CGM.Comment: 18 pages, 11 figures, Accepted to MNRA

A pilot study comparing three bend angles for lighted stylet intubation

Background For successful lighted stylet intubation, bending the lighted stylet with an appropriate angle is a prerequisite. The purpose of this study was to compare three different bend angles of 70, 80, and 90 degrees for lighted stylet intubation. Methods The patient trachea was intubated with a lighted stylet bent at 70, 80, or 90 degrees according to the randomly allocated groups (group I, II, and III, respectively). A lighted stylet combined with a tracheal tube was prepared with a bend angle of 70, 80, or 90 degrees according to the assigned group. We checked the success rate at the first attempt and overall success rate for the two attempts. Additionally, we measured search time, which was time from insertion of the bent union into the patient mouth to the start of advancing the tracheal tube while separating it from the lighted stylet, and evaluated postoperative sore throat (POST) at 2, 4, and 24 h after the recovery from anesthesia. Results There was no statistically significant difference between group I, II, and III for success rate at first attempt (73.9 %, 88.2 %, and 94.7 %, respectively, p = 0.178), even though there was a trend of increasing success rate with increasing bend angles. For overall success rate, there was similar result to that in the first attempt between the groups I, II, and III (82.6 %, 94.1 %, and 100 %, respectively, p = 0.141). However, search time took significantly longer in group I than groups II and III (p < 0.001). When group II and III were compared for POST with numeric rating scale (0–10), it was significantly lower in group II than III at 2, 4 h after the recovery (0.5 vs. 2.3, p = 0.016, and 0.4 vs. 1.8, p = 0.011, respectively). Conclusions The bend angle of the lighted stylet affected the time required for tracheal intubation and POST in our study. 80 and 90 degrees as a bend angle seem to be acceptable for clinicians in regard to success rate of lighted stylet intubation. Considering the success rate of lighted stylet intubation and POST, the bend angle of 80 degrees might be better than 70 and 90 degrees. Trial registration ClinicalTrials.gov Identifier NCT03693235 , registered on 30 September 2018

High peak inspiratory pressure may be associated with intraoperative coughing during neurosurgery under general anesthesia without neuromuscular blockade: a retrospective study

Background The endotracheal cuff pressure depends on the airway pressure during positive-pressure ventilation. A high endotracheal cuff pressure may be related to intraoperative coughing, which can be detrimental during neurosurgery. We investigated the incidence of intraoperative coughing and its association with peak inspiratory pressure (PIP) during neurosurgery under general anesthesia without neuromuscular blockade. Methods This retrospective study divided 1656 neurosurgical patients who underwent total intravenous anesthesia without additional neuromuscular blockade after tracheal intubation into high (PIP > 21.6 cmH2O, n = 318) and low (PIP ≤ 21.6 cmH2O, n = 1338) PIP groups. After propensity score matching, 206 patients were selected in each group. Demographic, preoperative, surgical, and anesthetic data were collected retrospectively from electronic medical records and continuous ventilator, infusion pump, and bispectral index data from a data registry. Results Intraoperative coughing occurred in 30 (1.8%) patients, including 9 (0.5%) during the main surgical procedure. Intraoperative coughing was more frequent in the high PIP group than in the low PIP group before (14/318 [4.4%] vs. 16/1338 [1.2%], P < 0.001) and after (13/206 [6.3%] vs. 1/206 [0.5%], P = 0.003) propensity score matching. In multivariable logistic regression analysis after propensity score matching, a high PIP (odds ratio [95% confidence interval] 14.22 [1.81-111.73], P = 0.012), tidal volume divided by predicted body weight (mL/kg, 1.36 [1.09–1.69], P = 0.006), and surgical duration (min, 1.01 [1.00–1.01], P = 0.025) predicted intraoperative coughing. Conclusion The incidence of intraoperative coughing was 1.8% in neurosurgical patients undergoing general anesthesia without neuromuscular blockade and might be associated with a high PIP

Flexible electromagnetic interference shields made of silver flakes, carbon nanotubes and nitrile butadiene rubber

The recent advances in portable and flexible electronic devices demand integration of flexibility into future electromagnetic interference shielding materials. Here we synthesized flexible adhesive shields made of microscale silver flakes (Ag flakes), multi-walled carbon nanotubes decorated with nanoscale silver particles (nAg-MWNTs), and nitrile butadiene rubber (NBR). The addition of nAg-MWNTs into the Ag flake-NBR mixture significantly enhanced both conductivity and shielding effectiveness. Long nanotubes electrically linked microscale Ag flakes embedded in the NBR matrix, and nanoscale silver particles further improved the contact interface. There was a logarithmic relationship between the conductivity and shielding effectiveness. The dominant mechanism of electromagnetic interference shielding was reflection. The achieved maximum shielding effectiveness was about ∼75 dB at 1 GHz. The flexible adhesive shield printed on a polyimide film was wrapped around a cylindrical rod with a radius of 4 mm. The shielding effectiveness decreased about 20% after 100 wrapping cycles. The conductivity and shielding effectiveness could be adjusted by changing the Ag flake concentration. There was an excellent agreement between the theoretically predicted shielding effectiveness and the experimental data. © 2013 Elsevier Ltd. All rights reserved.144461sciescopu

Evaluation of the conventional and modified aerosol boxes during tracheal intubation in normal and difficult airways: a randomized, crossover, manikin simulation study

© 2022, The Author(s), under exclusive licence to Springer Nature B.V.The aim of this study was to evaluate conventional and modified aerosol boxes in terms of intubation time, first-pass intubation success, and mouth-to-mouth distance between the laryngoscopist and patient during tracheal intubation in simulated patients with normal and difficult airways. Sixteen anesthesiologists performed tracheal intubations with direct laryngoscope or three different videolaryngoscopes (McGRATH MAC videolaryngoscope, C-MAC videolaryngoscope, and Pentax-AWS) without an aerosol box or with a conventional or a modified aerosol boxes in simulated manikins with normal and difficult airways. Intubation time, first-pass intubation success, and mouth-to-mouth distance during tracheal intubation were recorded. Compared to no aerosol box, the use of a conventional aerosol box significantly increased intubation time in both normal and difficult airways (Bonferroni-corrected P-value (Pcorrected) = 0.005 and Pcorrected = 0.003, respectively). Intubation time was significantly shorter with the modified aerosol box than with the conventional one for both normal and difficult airways (Pcorrected = 0.003 and Pcorrected = 0.011, respectively). However, no significant differences were found in intubation time between no aerosol box and the modified aerosol box for normal and difficult airways (Pcorrected = 0.336 and Pcorrected = 0.112, respectively). The use of conventional or modified aerosol boxes significantly extended the mouth-to-mouth distances compared to not using an aerosol box during tracheal intubation with each laryngoscope (all Pcorrected &lt; 0.05), and the distances were not different between the conventional and modified boxes in normal and difficult airways. The use of modified aerosol box did not increase intubation time and could help maintain a distance from the simulated patients with normal and difficult airways.N

RPE65 from Cone-dominant Chicken Is a More Efficient Isomerohydrolase Compared with That from Rod-dominant Species*

Cones recover their photosensitivity faster than rods after bleaching. It has been suggested that a higher rate regeneration of 11-cis-retinal, the chromophore for visual pigments, is required for cones to continuously function under bright light conditions. RPE65 is the isomerohydrolase catalyzing a key step in regeneration of 11-cis-retinal. The present study investigated whether RPE65 in a cone-dominant species is more efficient in its enzymatic activity than that from roddominant species. In vitro isomerohydrolase activity assay showed that isomerohydrolase activity in the chicken retinal pigment epithelium (RPE) was 11.7-fold higher than in the bovine RPE, after normalization by RPE65 protein levels. Similar to that of human and bovine, the isomerohydrolase activity in chicken RPE was blocked by two specific inhibitors of lecithin retinal acyltransferase, indicating that chicken RPE65 also uses all-trans-retinyl ester as the direct substrate. To exclude the possibility that the higher isomerohydrolase activity in the chicken RPE could arise from another unknown isomerohydrolase, we expressed chicken and human RPE65 using the adenovirus system in a stable cell line expressing lecithin retinal acyltransferase. Under the same conditions, isomerohydrolase activity of recombinant chicken RPE65 was 7.7-fold higher than that of recombinant human RPE65, after normalization by RPE65 levels. This study demonstrates that RPE65 from the cone-dominant chicken RPE possesses significantly higher specific retinol isomerohydrolase activity, when compared with RPE65 from rod-dominant species, consistent with the faster regeneration rates of visual pigments in cone-dominant retinas