3,520 research outputs found
Elements in potable groundwater in Rugao longevity area, China : Hydrogeochemical characteristics, enrichment patterns and health assessments
The simulated performance of GRANDProto300
GRANDProto300 is a 300-antenna prototype array of the envisioned GRAND (Giant
Radio Array for Neutrino Detection) project. The goal of GRANDProto300 is to
detect radio signals emitted by cosmic ray-induced air showers, with energies
ranging from ~eV to ~eV, which covers the transition
region between Galactic and extragalactic sources. We use simulations to
optimize the layout of GRANDProto300 and develop a shower reconstruction
method. Based on them, we present the performance of GRANDProto300 for
cosmic-ray detection, by means of its effective area, angular resolution, and
energy resolution.Comment: Presented at the 38th International Cosmic Ray Conference (ICRC
2023), 8 pages, 9 figure
First look at data from the 13-antenna setup of GRANDProto300 in northwest China
The Giant Radio Array for Neutrino Detection (GRAND) is an envisioned
observatory of ultra-high-energy neutrinos, cosmic rays, and gamma rays, with
energies above 100 PeV. GRAND targets the radio signals emitted by extensive
air showers induced by the interaction of ultra-high-energy particles in the
atmosphere, using an array of 200,000 radio antennas split into sub-arrays
deployed worldwide. GRANDProto13 (GP13) is a 13-antenna demonstrator array
deployed in February 2023 in the Gansu province of China, as a precursor for
GRANDProto300, which will validate the detection principle of the GRAND
experiment. Its goal is to measure the radio background present at the site,
validate the design of the detection units and develop an autonomous radio
trigger for air showers. We will describe GP13 and its operation, and show
preliminary results on noise monitoring.Comment: Proceedings of the 38th International Cosmic Ray Conference
(ICRC2023
The emerging role of deubiquitylating enzymes as therapeutic targets in cancer metabolism.
Cancer cells must rewire cellular metabolism to satisfy the unbridled proliferation, and metabolic reprogramming provides not only the advantage for cancer cell proliferation but also new targets for cancer treatment. However, the plasticity of the metabolic pathways makes them very difficult to target. Deubiquitylating enzymes (DUBs) are proteases that cleave ubiquitin from the substrate proteins and process ubiquitin precursors. While the molecular mechanisms are not fully understood, many DUBs have been shown to be involved in tumorigenesis and progression via controlling the dysregulated cancer metabolism, and consequently recognized as potential drug targets for cancer treatment. In this article, we summarized the significant progress in understanding the key roles of DUBs in cancer cell metabolic rewiring and the opportunities for the application of DUBs inhibitors in cancer treatment, intending to provide potential implications for both research purpose and clinical applications
Cold quark matter in a quasiparticle model: thermodynamic consistency and stellar properties
The strong coupling in the effective quark mass was usually taken as a
constant in a quasiparticle model while it is, in fact, running with an energy
scale. With a running coupling, however, the thermodynamic inconsistency
problem appears in the conventional treatment. We show that the renormalization
subtraction point should be taken as a function of the summation of the
biquadratic chemical potentials if the quark's current masses vanish, in order
to ensure full thermodynamic consistency. Taking the simplest form, we study
the properties of up-down () quark matter, and confirm that the revised
quasiparticle model fulfills the quantitative criteria for thermodynamic
consistency. Moreover, we find that the maximum mass of an quark star can
be larger than two times the solar mass, reaching up to , for
reasonable model parameters. However, to further satisfy the upper limit of
tidal deformability observed in the event
GW170817, the maximum mass of an quark star can only be as large as
, namely . In other words,
our results indicate that the measured tidal deformability for event GW170817
places an upper bound on the maximum mass of quark stars, but which does
not rule out the possibility of the existence of quark stars composed of
quark matter, with a mass of about two times the solar mass.Comment: 10 pages, 8 figure
Automatic identification and analysis of cells using digital holographic microscopy and Sobel segmentation
Counting and analyzing of blood cells, as well as their subcellular structures, are indispensable for understanding biological processes, studying cell functions, and diagnosing diseases. In this paper, we combine digital holographic microscopy with cell segmentation guided by the Sobel operator using Dice coefficients for automatic threshold selection and aimed to automatic counting and analysis of blood cells in flow and different kinds of cells in the static state. We demonstrate the proposed method with automatic counting and analyzing rat red blood cells (RBCS) flowing in a microfluidic device, extracting quickly and accurately the size, concentration, and dry mass of the sample in a label-free manner. The proposed technique was also demonstrated for automatic segmentation of different cell types, such as COS7 and Siha. This method can help us in blood inspection, providing pathological information in disease diagnosis and treatment
Study of the Global Alignment for the DAMPE Detector
The Dark Matter Particle Explorer (DAMPE) is designed as a high energy
particle detector for probing cosmic-rays and rays in a wide energy
range. The trajectory of the incident particle is mainly measured by the
Silicon-Tungsten tracKer-converter (STK) sub-detector, which heavily depends on
the precise internal alignment correction as well as the accuracy of the global
coordinate system. In this work, we carried out a global alignment method to
validate the potential displacement of these sub-detectors, and particularly
demonstrated that the track reconstruction of STK can well satisfy the required
objectives by means of comparing flight data and simulations.Comment: 18 pages, 11 figure
Antidiabetic retinopathy effect of Fufang Danshen Mingmu in rats
Purpose: To investigate the effect of Fufang Danshen Mingmu (FDM) on streptozotocin-induced diabetic retinopathy rats.Methods: Diabetic retinopathy model rats were prepared using a single intraperitoneal injection of a freshly prepared solution of streptozotocin (50 mg/kg). The rats were randomly divided into 6 groups of ten rats each: negative control group, control group, reference group (glibenclamide, 1 mg/kg) as well as FDM groups, (50, 100 and 200 mg/kg body weight). Blood glucose and plasma insulin levels were determined. Oxidative stress was evaluated in liver and kidney as lipid peroxidation (LPO), superoxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GPx) and catalase (CAT). Blood serum levels of creatinine and urea were determined in both diabetic control and treated rats.Results: Compared with diabetic rats, oral administration of FDM at a dose of 200 mg/kg daily for 30 days resulted in a significant decrease in fasting blood glucose (120.21 ± 3.37 mg/dL, p < 0.05) and increased insulin level (13.31 ± 0.67 uU/mL, p < 0.05). Furthermore, it significantly reduced biochemical parameters (serum creatinine, 0.86 ±0.24 mg/dL, p < 0.05) and serum urea 41.86±1.59 mg/dL, p <0.05).Conclusion: The results indicate that FDM normalizes impaired antioxidant status in streptozotocin induced diabetic retinopathy rats, and also exerts a protective effect against lipid peroxidation by scavenging free radicals
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