60 research outputs found
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Building thermal performance, extreme heat, and climate change
The leading source of weather-related deaths in the United States is heat, and future projections show that the frequency, duration, and intensity of heat events will increase in the Southwest. Presently, there is a dearth of knowledge about how infrastructure may perform during heat waves or could contribute to social vulnerability. To understand how buildings perform in heat and potentially stress people, indoor air temperature changes when air conditioning is inaccessible are modeled for building archetypes in Los Angeles, California, and Phoenix, Arizona, when air conditioning is inaccessible is estimated. An energy simulation model is used to estimate how quickly indoor air temperature changes when building archetypes are exposed to extreme heat. Building age and geometry (which together determine the building envelope material composition) are found to be the strongest indicators of thermal envelope performance. Older neighborhoods in Los Angeles and Phoenix (often more centrally located in the metropolitan areas) are found to contain the buildings whose interiors warm the fastest, raising particular concern because these regions are also forecast to experience temperature increases. To combat infrastructure vulnerability and provide heat refuge for residents, incentives should be adopted to strategically retrofit buildings where both socially vulnerable populations reside and increasing temperatures are forecast
Exercise-Induced Fatigue and Caffeine Supplementation Affect Psychomotor Performance but Not Covert Visuo-Spatial Attention
Fatigue resulting from strenuous exercise can impair cognition and oculomotor control. These impairments can be prevented by administering psychostimulants such as caffeine. This study used two experiments to explore the influence of caffeine administered at rest and during fatiguing physical exercise on spatial attention—a cognitive function that is crucial for task-based visually guided behavior. In independent placebo controlled studies, cohorts of 12 healthy participants consumed caffeine and rested or completed 180 min of stationary cycling. Covert attentional orienting was measured in both experiments using a spatial cueing paradigm. We observed no alterations in attentional facilitation toward spatial cues suggesting that covert attentional orienting is not influenced by exercise fatigue or caffeine supplementation. Response times were increased (impaired) after exercise and this deterioration was prevented by caffeine supplementation. In the resting experiment, response times across all conditions and cues were decreased (improved) with caffeine.
Covert spatial attention was not influenced by caffeine. Together, the results of these experiments suggest that covert attentional orienting is robust to the effects of fatiguing exercise and not influenced by caffeine. However, exercise fatigue impairs response times, which can be prevented by caffeine, suggesting that pre-motor planning and execution of the motor responses required for performance of the cueing task are sensitive to central nervous system fatigue. Caffeine improves response time in both fatigued and fresh conditions, most likely through action on networks controlling motor function
Epigenomic and functional analyses reveal roles of epialleles in the loss of photoperiod sensitivity during domestication of allotetraploid cottons
Abstract Background Polyploidy is a pervasive evolutionary feature of all flowering plants and some animals, leading to genetic and epigenetic changes that affect gene expression and morphology. DNA methylation changes can produce meiotically stable epialleles, which are transmissible through selection and breeding. However, the relationship between DNA methylation and polyploid plant domestication remains elusive. Results We report comprehensive epigenomic and functional analyses, including ~12 million differentially methylated cytosines in domesticated allotetraploid cottons and their tetraploid and diploid relatives. Methylated genes evolve faster than unmethylated genes; DNA methylation changes between homoeologous loci are associated with homoeolog-expression bias in the allotetraploids. Significantly, methylation changes induced in the interspecific hybrids are largely maintained in the allotetraploids. Among 519 differentially methylated genes identified between wild and cultivated cottons, some contribute to domestication traits, including flowering time and seed dormancy. CONSTANS (CO) and CO-LIKE (COL) genes regulate photoperiodicity in Arabidopsis. COL2 is an epiallele in allotetraploid cottons. COL2A is hypermethylated and silenced, while COL2D is repressed in wild cottons but highly expressed due to methylation loss in all domesticated cottons tested. Inhibiting DNA methylation activates COL2 expression, and repressing COL2 in cultivated cotton delays flowering. Conclusions We uncover epigenomic signatures of domestication traits during cotton evolution. Demethylation of COL2 increases its expression, inducing photoperiodic flowering, which could have contributed to the suitability of cotton for cultivation worldwide. These resources should facilitate epigenetic engineering, breeding, and improvement of polyploid crops
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Electricity infrastructure vulnerabilities due to long-term growth and extreme heat from climate change in Los Angeles County
Many studies have estimated the effects of rising air temperatures due to climate change on electricity infrastructure systems, but none have quantified impacts in terms of potential outages down to the neighborhood scale. Using high-resolution climate projections, infrastructure maps, and forecasts of peak electricity demand for Los Angeles County (LAC), we estimated vulnerabilities in the electricity infrastructure to 2060. We considered rising air temperatures under IPCC RCP 4.5 and RCP 8.5 at 2 km2 grid cell resolution, two local government population growth scenarios, different efficiency implementations of new residential and commercial buildings, air conditioners (AC), and higher AC penetration. Results were that generators, substations, and transmission lines could lose up to 20% of safe operating capacities (MW). Moreover, based on recent historical load factors for substations in the Southern California Edison service territory, 848–6724 MW (4–32%) of additional capacity, distributed energy resources, and/or peak load shifting could be needed by 2060 to avoid hardware overloading and outages. If peak load is not mitigated, and/or additional infrastructure capacity not added, then all scenarios result in > 100% substation overloading in Santa Clarita, which would trigger automatic outages, and > 20% substation overloading in at least Lancaster, Palmdale, and Pomona in which protection gear could trip outages within 30 min. Several climate change adaptation options are discussed for electricity infrastructure and building stock with consideration for trade-offs in system stability and other energy and environmental goals
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Forecasting peak electricity demand for Los Angeles considering higher air temperatures due to climate change
Los Angeles County (LAC) is a large urbanized region with 9.7 million residents (as of 2010) and aging infrastructure. Population forecasts indicate that LAC will become home to an additional 1.2–3.1 million residents through 2060. Additionally, climate forecasts based upon representative concentration pathway (RCP) scenarios 4.5 and 8.5 indicate that average air temperatures will increase by 1–4 °C (2–7 °F) in the region. Both of these factors are expected to result in higher summertime peak electricity demand due to growth in the number of buildings, the percentage of installed air conditioners (ACs), and the additional cooling load on those air conditioners. In order to understand potential power reliability issues, and support infrastructure planning efforts, a long-term peak demand forecast was developed using hourly residential and commercial (R&C) building energy models. Peak hour electricity demand was estimated to increase from 9.5 to 12.8 GW for R&C sectors, to 13.0–17.3 GW (2–36%) and 14.7–19.2 GW (16–51%) by 2060 for the population forecasts from the California Department of Finance and the Southern California Association of Governments respectively. While marginal increases in ambient air temperature due to climate change accounted for only 4–8% of future increases in peak demand, differences in annual maximum temperatures within the 20-year periods affected results by 40–66% indicating a high sensitivity to heat waves. Population growth of at least 1 million people is anticipated to occur mostly in the northern cities of Palmdale, Lancaster, and Santa Clarita, bringing an additional 0.4–1 GW of peak demand in those regions. Building and AC efficiency are anticipated to improve as national and state efficiency standards increase, and as older, less efficient units are replaced; this could offset some of the projected increases in peak demand. Additionally, development of shared wall, multi-family dwelling units could enable population growth of up to 3 million people without increasing peak demand
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Household accessibility to heat refuges: Residential air conditioning, public cooled space, and walkability
Access to air conditioned space is critical for protecting urban populations from the adverse effects of heat exposure. Yet there remains fairly limited knowledge of the penetration of private (home air conditioning) and distribution of public (cooling centers and commercial space) cooled space across cities. Furthermore, the deployment of government-sponsored cooling centers is likely to be inadequately informed with respect to the location of existing cooling resources (residential air conditioning and air conditioned public space), raising questions of the equitability of access to heat refuges. We explore the distribution of private and public cooling resources and access inequities at the household level in two major US urban areas: Los Angeles County, California and Maricopa County, Arizona (whose county seat is Phoenix). We evaluate the presence of in-home air conditioning and develop a walking-based accessibility measure to air conditioned public space using a combined cumulative opportunities-gravity approach. We find significant variations in the distribution of residential air conditioning across both regions which are largely attributable to building age and inter/intra-regional climate differences. There are also regional disparities in walkable access to public cooled space. At average walking speeds, we find that official cooling centers are only accessible to a small fraction of households (3% in Los Angeles, 2% in Maricopa) while a significantly higher number of households (80% in Los Angeles, 39% in Maricopa) have access to at least one other type of public cooling resource such as a library or commercial establishment. Aggregated to a neighborhood level, we find that there are areas within each region where access to cooled space (either public or private) is limited which may increase heat-related health risks
Accelerated BEP: A phase I trial of dose-dense BEP for intermediate and poor prognosis metastatic germ cell tumour
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