38,955 research outputs found
The Rocketdyne Multifunction Tester. Part 2: Operation of a Radial Magnetic Bearing as an Excitation Source
The operation of the magnetic bearing used as an excitation source in the Rocketdyne Multifunction Tester is described. The tester is scheduled for operation during the summer of 1990. The magnetic bearing can be used in two control modes: (1) open loop mode, in which the magnetic bearing operates as a force actuator; and (2) closed loop mode, in which the magnetic bearing provides shaft support. Either control mode can be used to excite the shaft; however, response of the shaft in the two control modes is different due to the alteration of the eigenvalues by closed loop mode operation. A rotordynamic model is developed to predict the frequency response of the tester due to excitation in either control mode. Closed loop mode excitation is shown to be similar to the excitation produced by a rotating eccentricity in a conventional bearing. Predicted frequency response of the tester in the two control modes is compared, and the maximum response is shown to be the same for the two control modes when synchronous unbalance loading is not considered. The analysis shows that the response of this tester is adequate for the extraction of rotordynamic stiffness, damping, and inertia coefficients over a wide range of test article stiffnesses
A two-compartment mechanochemical model of the roles of\ud transforming growth factor β and tissue tension in dermal wound healing
The repair of dermal tissue is a complex process of interconnected phenomena, where cellular, chemical and mechanical aspects all play a role, both in an autocrine and in a paracrine fashion. Recent experimental results have shown that transforming growth factor−β (TGFβ) and tissue mechanics play roles in regulating cell proliferation, differentiation and the production of extracellular materials. We have developed a 1D mathematical model that considers the interaction between the cellular, chemical and mechanical phenomena, allowing the combination of TGFβ and tissue stress to inform the activation of fibroblasts to myofibroblasts. Additionally, our model incorporates the observed feature of residual stress by considering the changing zero-stress state in the formulation for effective strain. Using this model, we predict that the continued presence of TGFβ in dermal wounds will produce contractures due to the persistence of myofibroblasts; in contrast, early elimination of TGFβ significantly reduces the myofibroblast numbers resulting in an increase in wound size. Similar results were obtained by varying the rate at which fibroblasts differentiate to myofibroblasts and by changing the myofibroblast apoptotic rate. Taken together, the implication is that elevated levels of myofibroblasts is the key factor behind wounds healing with excessive contraction, suggesting that clinical strategies which aim to reduce the myofibroblast density may reduce the appearance of contractures
A fibrocontractive mechanochemical model of dermal wound\ud closure incorporating realistic growth factor kinetics
Fibroblasts and their activated phenotype, myofibroblasts, are the primary cell types involved in the contraction associated with dermal wound healing. Recent experimental evidence indicates that the transformation from fibroblasts to myofibroblasts involves two distinct processes: the cells are stimulated to change phenotype by the combined actions of transforming growth factor β (TGFβ) and mechanical tension. This observation indicates a need for a detailed exploration of the effect of the strong interactions between the mechanical changes and growth factors in dermal wound healing. We review the experimental findings in detail and develop a model of dermal wound healing that incorporates these phenomena. Our model includes the interactions between TGFβ and collagenase, providing a more biologically realistic form for the growth factor kinetics than those included in previous mechanochemical descriptions. A comparison is made between the model predictions and experimental data on human dermal wound healing and all the essential features are well matched
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Free healthy breakfasts in primary schools: A cluster randomised controlled trial of a policy intervention in Wales, UK
Objective: The present study evaluated the impact of a national school programme of universal free healthy breakfast provision in Wales, UK.
Design: A cluster randomised controlled trial with repeated cross-sectional design and a 12-month follow-up. Primary outcomes were breakfast skipping, breakfast diet and episodic memory. Secondary outcomes were frequency of eating breakfast at home and at school, breakfast attitudes, rest-of-day diet and class behaviour.
Setting: Primary schools in nine local education authority areas.
Subjects: A total of 4350 students (aged 9–11 years) at baseline and 4472 at follow-up in 111 schools.
Results: Students in intervention schools reported significantly higher numbers of healthy food items consumed at breakfast and more positive attitudes towards breakfast eating at 12 months. Parents in intervention schools reported significantly higher rates of consumption of breakfast at school and correspondingly lower rates of breakfast consumption at home. No other significant differences were found.
Conclusions: The intervention did not reduce breakfast skipping; rather, pupils substituted breakfast at home for breakfast at school. However, there were improvements in children’s nutritional intake at breakfast time, if not the rest of the day, and more positive attitudes to breakfast, which may have implications for life-course dietary behaviours. There was no impact on episodic memory or classroom behaviour, which may require targeting breakfast skippers
Comparison of CDMA and FDMA for the MobileStar(sm) system
Spread-spectrum code division multiple access (CDMA) and single channel per carrier frequency division multiple access (FDMA) systems are compared for spectrum efficiency. CDMA is shown to have greater maximum throughput than FDMA for the MobileStar(sm) system which uses digital voice activated carriers and directive circularly polarized satellite antennas
Intrinsic dissipation in high-frequency micromechanical resonators
We report measurements of intrinsic dissipation in micron-sized suspended resonators machined from single crystals of galium arsenide and silicon. In these experiments on high-frequency micromechanical resonators, designed to understand intrinsic mechanisms of dissipation, we explore dependence of dissipation on temperature, magnetic field, frequency, and size. In contrast to most of the previous measurements of acoustic attenuation in crystalline and amorphous structures in this frequency range, ours is a resonant measurement; dissipation is measured at the natural frequencies of structural resonance, or modes of the structure associated with flexural and torsional motion. In all our samples we find a weakly temperature dependent dissipation at low temperatures. We compare and contrast our data to various probable mechanisms, including thermoelasticity, clamping, anharmonic mode-coupling, surface anisotropy and defect motion, both in bulk and on surface. The observed parametric dependencies indicate that the internal defect motion is the dominant mechanism of intrinsic dissipation in our samples
‘A double-edged sword. This is powerful but it could be used destructively’: Perspectives of early career education researchers on learning analytics
Learning analytics has been increasingly outlined as a powerful tool for measuring, analysing, and predicting learning experiences and behaviours. The rising use of learning analytics means that many educational researchers now require new ranges of technical analytical skills to contribute to an increasingly data-heavy field. However, it has been argued that educational data scientists are a ‘scarce breed’ (Buckingham Shum et al., 2013) and that more resources are needed to support the next generation of early career researchers in the education field. At the same time, little is known about how early career education researchers feel towards learning analytics and whether it is important to their current and future research practices. Using a thematic analysis of a participatory learning analytics workshop discussions with 25 early career education researchers, we outline in this article their ambitions, challenges and anxieties towards learning analytics. In doing so, we have provided a roadmap for how the learning analytics field might evolve and practical implications for supporting early career researchers’ development
Practical Bayesian Modeling and Inference for Massive Spatial Datasets On Modest Computing Environments
With continued advances in Geographic Information Systems and related
computational technologies, statisticians are often required to analyze very
large spatial datasets. This has generated substantial interest over the last
decade, already too vast to be summarized here, in scalable methodologies for
analyzing large spatial datasets. Scalable spatial process models have been
found especially attractive due to their richness and flexibility and,
particularly so in the Bayesian paradigm, due to their presence in hierarchical
model settings. However, the vast majority of research articles present in this
domain have been geared toward innovative theory or more complex model
development. Very limited attention has been accorded to approaches for easily
implementable scalable hierarchical models for the practicing scientist or
spatial analyst. This article is submitted to the Practice section of the
journal with the aim of developing massively scalable Bayesian approaches that
can rapidly deliver Bayesian inference on spatial process that are practically
indistinguishable from inference obtained using more expensive alternatives. A
key emphasis is on implementation within very standard (modest) computing
environments (e.g., a standard desktop or laptop) using easily available
statistical software packages without requiring message-parsing interfaces or
parallel programming paradigms. Key insights are offered regarding assumptions
and approximations concerning practical efficiency.Comment: 20 pages, 4 figures, 2 table
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