263 research outputs found
Outcome measures of electroacoustic hearing – a questionnaire to evaluate bimodal satisfaction
Long-term degradation of optical devices on the moon
Forty years ago, Apollo astronauts placed the first of several retroreflector
arrays on the lunar surface. Their continued usefulness for laser-ranging might
suggest that the lunar environment does not damage optical devices. However,
new laser ranging data reveal that the efficiency of the three Apollo reflector
arrays is now diminished by a factor of ten at all lunar phases and by an
additional factor of ten when the lunar phase is near full moon. These deficits
did not exist in the earliest years of lunar ranging, indicating that the lunar
environment damages optical equipment on the timescale of decades. Dust or
abrasion on the front faces of the corner-cube prisms may be responsible,
reducing their reflectivity and degrading their thermal performance when
exposed to face-on sunlight at full moon. These mechanisms can be tested using
laboratory simulations and must be understood before designing equipment
destined for the moon.Comment: 9 pages; 4 figures; accepted for publication in Icaru
An Electron Paramagnetic Resonance (EPR) spectroscopy study on the γ-irradiation sterilization of the pharmaceutical excipient l-histidine: Regeneration of the radicals in solution
The effects of γ-radiation sterilization on the parenteral excipient L-histidine were analysed by means of EPR spectroscopy. The irradiation process was found to induce the formation of a deamination radical which was persistent in the solid state. The nature and reactivity of the radicals following dissolution in water was evaluated using spin-trapping EPR experiments. The deamination radical was found to regenerate in solution in the presence of trace metals, potentially leading to radical induced degradation reactions occurring up to an hour after the dissolution process. Understanding this process is significant for the improved design of parental pharmaceutical formulations in which unwanted radical reactions after γ radiation sterilization could lead to degradation of active ingredients
Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA
Endogenous 5-methylcytosine (MeC) residues are found at all CG dinucleotides of the p53 tumor suppressor gene, including the mutational ‘hotspots' for smoking induced lung cancer. MeC enhances the reactivity of its base paired guanine towards carcinogenic diolepoxide metabolites of polycyclic aromatic hydrocarbons (PAH) present in cigarette smoke. In the present study, the structural basis for these effects was investigated using a series of unnatural nucleoside analogs and a representative PAH diolepoxide, benzo[a]pyrene diolepoxide (BPDE). Synthetic DNA duplexes derived from a frequently mutated region of the p53 gene (5′-CCCGGCACCC GC[15N3,13C1-G]TCCGCG-3′, + strand) were prepared containing [15N3, 13C1]-guanine opposite unsubstituted cytosine, MeC, abasic site, or unnatural nucleobase analogs. Following BPDE treatment and hydrolysis of the modified DNA to 2′-deoxynucleosides, N2-BPDE-dG adducts formed at the [15N3, 13C1]-labeled guanine and elsewhere in the sequence were quantified by mass spectrometry. We found that C-5 alkylcytosines and related structural analogs specifically enhance the reactivity of the base paired guanine towards BPDE and modify the diastereomeric composition of N2-BPDE-dG adducts. Fluorescence and molecular docking studies revealed that 5-alkylcytosines and unnatural nucleobase analogs with extended aromatic systems facilitate the formation of intercalative BPDE-DNA complexes, placing BPDE in a favorable orientation for nucleophilic attack by the N2 position of guanin
Random Convex Hulls and Extreme Value Statistics
In this paper we study the statistical properties of convex hulls of
random points in a plane chosen according to a given distribution. The points
may be chosen independently or they may be correlated. After a non-exhaustive
survey of the somewhat sporadic literature and diverse methods used in the
random convex hull problem, we present a unifying approach, based on the notion
of support function of a closed curve and the associated Cauchy's formulae,
that allows us to compute exactly the mean perimeter and the mean area enclosed
by the convex polygon both in case of independent as well as correlated points.
Our method demonstrates a beautiful link between the random convex hull problem
and the subject of extreme value statistics. As an example of correlated
points, we study here in detail the case when the points represent the vertices
of independent random walks. In the continuum time limit this reduces to
independent planar Brownian trajectories for which we compute exactly, for
all , the mean perimeter and the mean area of their global convex hull. Our
results have relevant applications in ecology in estimating the home range of a
herd of animals. Some of these results were announced recently in a short
communication [Phys. Rev. Lett. {\bf 103}, 140602 (2009)].Comment: 61 pages (pedagogical review); invited contribution to the special
issue of J. Stat. Phys. celebrating the 50 years of Yeshiba/Rutgers meeting
Scaling and nonscaling finite-size effects in the Gaussian and the mean spherical model with free boundary conditions
We calculate finite-size effects of the Gaussian model in a L\times \tilde
L^{d-1} box geometry with free boundary conditions in one direction and
periodic boundary conditions in d-1 directions for 2<d<4. We also consider film
geometry (\tilde L \to \infty). Finite-size scaling is found to be valid for
d3 but logarithmic deviations from finite-size scaling are found for
the free energy and energy density at the Gaussian upper borderline dimension
d* =3. The logarithms are related to the vanishing critical exponent
1-\alpha-\nu=(d-3)/2 of the Gaussian surface energy density. The latter has a
cusp-like singularity in d>3 dimensions. We show that these properties are the
origin of nonscaling finite-size effects in the mean spherical model with free
boundary conditions in d>=3 dimensions. At bulk T_c in d=3 dimensions we find
an unexpected non-logarithmic violation of finite-size scaling for the
susceptibility \chi \sim L^3 of the mean spherical model in film geometry
whereas only a logarithmic deviation \chi\sim L^2 \ln L exists for box
geometry. The result for film geometry is explained by the existence of the
lower borderline dimension d_l = 3, as implied by the Mermin-Wagner theorem,
that coincides with the Gaussian upper borderline dimension d*=3. For 3<d<4 we
find a power-law violation of scaling \chi \sim L^{d-1} at bulk T_c for box
geometry and a nonscaling temperature dependence \chi_{surface} \sim \xi^d of
the surface susceptibility above T_c. For 2<d<3 dimensions we show the validity
of universal finite-size scaling for the susceptibility of the mean spherical
model with free boundary conditions for both box and film geometry and
calculate the corresponding universal scaling functions for T>=T_c.Comment: Submitted to Physical Review
Overexpression of the Matrix Metalloproteinase Matrilysin Results in Premature Mammary Gland Differentiation and Male Infertility
Collisional and Radiative Processes in Optically Thin Plasmas
Most of our knowledge of the physical processes in distant plasmas is obtained
through measurement of the radiation they produce. Here we provide an overview of the
main collisional and radiative processes and examples of diagnostics relevant to the microphysical
processes in the plasma. Many analyses assume a time-steady plasma with ion
populations in equilibrium with the local temperature and Maxwellian distributions of particle
velocities, but these assumptions are easily violated in many cases. We consider these
departures from equilibrium and possible diagnostics in detail
Psychology and aggression
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68264/2/10.1177_002200275900300301.pd
Orbital Observations of Dust Lofted by Daytime Convective Turbulence
Over the past several decades, orbital observations of lofted dust have revealed the importance of mineral aerosols as a climate forcing mechanism on both Earth and Mars. Increasingly detailed and diverse data sets have provided an ever-improving understanding of dust sources, transport pathways, and sinks on both planets, but the role of dust in modulating atmospheric processes is complex and not always well understood. We present a review of orbital observations of entrained dust on Earth and Mars, particularly that produced by the dust-laden structures produced by daytime convective turbulence called “dust devils”. On Earth, dust devils are thought to contribute only a small fraction of the atmospheric dust budget; accordingly, there are not yet any published accounts of their occurrence from orbit. In contrast, dust devils on Mars are thought to account for several tens of percent of the planet’s atmospheric dust budget; the literature regarding martian dust devils is quite rich. Because terrestrial dust devils may temporarily contribute significantly to local dust loading and lowered air quality, we suggest that martian dust devil studies may inform future studies of convectively-lofted dust on Earth
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