Endoscopic Mucosal Resection of Primary Anorectal Malignant Melanoma:A Case Report

Anorectal melanoma is a rare malignant tumor with a poor prognosis. However, several studies have reported cases of long-term survival. In this report, we present a patient with anorectal melanoma who has survived for 9 years after endoscopic mucosal resection. An 85-year-old man was referred to our hospital for further examination and treatment of an anal tumor 2cm in size. Endoscopic ultrasonography revealed that the depth of tumor invasion was confined to the submucosal layer. Endoscopic mucosal resection was performed, and the tumor was diagnosed as a malignant melanoma. The patient was followed without any additional treatment, which was per his wishes. Although melanoma recurred 4 times thereafter, endoscopic mucosal resection was performed for each recurrent lesion. Thus, he has been alive for 9 years since the first endoscopic mucosal resection without distant metastases. If the depth of tumor invasion is shallow, endoscopic mucosal resection is a useful option among other therapeutic modalities.</p

Proteinuria screening for children

Proteinuria screening for children.BackgroundIn Japan, urine screenings are performed annually at school for proteinuria and hematuria, but the effectiveness of this practice has not been clarified.MethodsUrine screening at school was performed, and we investigated the prevalence of urine abnormalities and incidence and the causes of their diseases. Therefore, we studied effectiveness of the school-screening program.ResultsThe prevalence of urinary abnormalities was 0.52% among elementary school children and 0.75% among junior high school children. The incidence was 0.24% among elementary school children. The school-screening program is effective in early detection of glomerulonephritis, so the number of new end-stage renal disease (ESRD) patients starting treatment has been changing.DiscussionThe school-screening program is effective for early detection of glomerulonephritis. In case of generations who underwent the school-screening program, the age that one develops ESRD has been rising year by year, and the number of new ESRD patients starting treatment before 20 years old is lower in Japan than in America.ConclusionThe school-screening program in Japan represents a highly effective mass screening technique

Formation of a Nanoscale hcp Structure by Crystallization of an Amorphous Co_<91>Zr_7B_2 Alloy

A mostly single hcp phase with grain sizes ranging from 3 to 10 nm was found to form as a metastable phase in the crystallization process of an amorphous Co_Zr_7B_2 alloy. The temperature range, in which the nanoscale hcp structure forms, extends from 800 to 900 K and the further heating above 900 K causes the phase transition to ε-Co+Co_(Zr, B)_6. No distinct grain growth in the hcp structure is seen in the temperature range of 800 to 900 K. The hcp phase has a lattice parameter of a=0.2507 nm and c=0.4066 nm which is slightly different from that of pure ε-Co presumably because of the dissolution of Zr and B. The Co_Zr_9 amorphous alloy crystallizes directly to a mixed phase of ε-Co+cubic Co_Zr_6 with a large grain size of about 0.4μm through a polymorphic-type crystallization mode. It is therefore concluded that the addition of a small amount of boron is essential for the formation of the nanoscale hcp structure

Changes in Lymphocyte Phenotypes and Cytokine Production by Surgical Stress in a Rat Small Intestinal Resection Model

Small intestinal resection rats are used widely as a malabsorption model, but the immunological changes are unclear. We examined the changes in systemic and mucosal immune status after a small intestinal resection in rats with a controlled nutritional status. Rats had 60% of their small intestine removed. At 5 days after the surgery, spleen cells and intraepithelial lymphocytes (IEL) were isolated. The phenotypes of spleen cells and IEL, the production patterns of Th1 and Th2 cytokines, and the proinflammatory cytokine levels in the plasma were measured. CD4+ T cells in the blood and spleen were significantly decreased in the Resection group (p<0.05). In contrast, IEL subpopulations were not different between the two groups. Interferon-γ production from the spleen cells was significantly decreased in the Resection group (p<0.05). Interleukin (IL)-4 production was not different between the two groups. Plasma IL-6 concentrations were significantly elevated in the Resection group 6 h after surgery (p<0.05). In conclusions, small intestinal resection in rats suppressed systemic immunity, and this model is useful as a surgical stress model

Absorption and Fluorescence Spectra of 10-Hydroxy-benzo [h] quinoline and 10-Methoxy-benzo [h] quinoline in various Solvents

Article信州大学工学部紀要 73: 39-48 (1993)departmental bulletin pape

Clinical Management of Implant Prostheses in Patients with Bruxism

There is general agreement that excessive stress to the bone-implant interface may result in implant overload and failure. Early failure of the implant due to excessive loading occurs shortly after uncovering the implant. Excess load on a final restoration after successful implant integration can result in physical failure of the implant structure. Many clinicians believe that overload of dental implants is a risk factor for vertical peri-implant bone loss and/or may be detrimental for the suprastructure in implant prostheses. It has been documented that occlusal parafunction, such as, bruxism (tooth grinding and clenching) affects the outcome of implant prostheses, but there is no evidence for a causal relation between the failures and overload of dental implants. In spite of this lack of evidence, often metal restorations are preferred instead of porcelain for patients in whom bruxism is presumed on the basis of tooth wear. The purpose of this paper is to discuss the importance of the occlusal scheme used in implant restorations for implant longevity and to suggest a clinical approach and occlusal materials for implant prostheses in order to prevent complications related to bruxism