4,482 research outputs found

    Enseñanzas mínimas de educación infantil : Real Decreto 1630-2006, de 29 de diciembre, por el que se establecen las enseñanzas mínimas del segundo ciclo de educación infantil

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    Se presenta el Real Decreto 1630-2006, de 29 de diciembre que establece las enseñanzas mínimas a impartirse en el segundo ciclo de educación infantil. Se indican los objetivos, contenidos y criterios de evaluación de cada una de las áreas que integran el segundo ciclo de educación infantil.MadridBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín 5 -3 Planta; 28014 Madrid; Tel. +34917748000; [email protected]

    Baseball Card Pricing Model: A Demonstration with Well-known Players

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    A simple hedonic pricing model is developed for baseball cards, of the type often used successfully to model prices for artworks. The model is estimated for a dataset of twelve well-known players observed at eight points in time over a span of twenty years. Dummy variables are used to capture various relevant characteristics of the player or card. This model was estimated separately for two different approaches or assumptions about rates of return. Estimates perform extremely well, explaining most differences among baseball card prices for the cards in the sample. Among extrinsic variables that represent specific players and card characteristics that differentiate cards issued during the same season, race had a significant positive effect on price for black players. Batting average and number of World Series appearances had significant positive impacts on price, but surprisingly, rookie cards tended to be worth relatively less than non-rookie cards. Similarly unexpected findings with respect to players\u27 death and elevation to the Hall of Fame may result from trying to estimate too many characteristics simultaneously on a limited dataset. Results suggest famous players\u27 cards generally are extremely attractive investment instruments

    \u3cem\u3eIn Situ\u3c/em\u3e Rumen Degradability of Perennial Ryegrass Cultivars Differing in Ploidy and Heading Date in Ireland

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    Grazed grass is the predominant feed in Irish dairy and beef cattle production systems. Knowledge of the degradability characteristics of protein in Irish forages is necessary for the establishment of protein values (PDIE and PDIN values) for these. This knowledge would also facilitate more accurate formulation of supplements for grass diets with the potential to reduce nitrogen (N) excretion

    The Effect of Nitrogen Fertiliser and Season on the \u3cem\u3ein Situ\u3c/em\u3e Degradability of Irish Perennial Ryegrass in Cattle

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    In light of increasing environmental and economic pressure on agriculture to utilise resources more efficiently, protein feeding and its effects are fundamentally important. As grazed grass is the predominant feed in Irish dairy and beef cattle production systems, it is necessary to establish protein values for different grass varieties and cultivars fed. It is also important to investigate the extent of ruminal nitrogen (N) degradability for these grasses since this characteristic greatly influences environmentally damaging urinary N excretion

    Being on the Juvenile Dermatomyositis Rollercoaster: a qualitative study

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    Objectives: Juvenile Dermatomyositis is a rare, potentially life-threatening condition with no known cure. There is no published literature capturinghow children and young people feel about their condition, from their perspective. This study was therefore unique in that it asked children and young people what is it like to live with Juvenile Dermatomyositis. Methods: Data wereobtained from fifteen young people with Juvenile Dermatomyositis, between eightand nineteen years of age from one Paediatric Rheumatology department using audio-recordedinterpretive phenomenology interviews. Data were analyzed phenomenologically, using a process that derives narratives from transcripts resulting in a collective composite of participants shared experiences, called a‘phenomenon’. Results:The overarching metaphor of a rollercoaster captures the phenomenon of living withJuvenile Dermatomyositisas a young person, with the ups and downs at different time points clearly described by those interviewed. The five themes plotted on the rollercoaster, began with confusion; followed by feeling different, being sick, steroidal and scared from the medications; uncertainty; and then ended with acceptance of the disease over time. Conclusion: Young people were able to talk about their experiences about having Juvenile Dermatomyositis. Our findings will aid clinicians in their practice by gaining a deeper understanding of what daily life is like and highlighting ways to enhance psychosocial functioning. Hopefully, this study and any further resulting studies,will raise understanding of Juvenile Dermatomyositis worldwide and will encourage health care professionals to better assess psychosocial needs in the future

    Management of type 2 diabetes mellitus in people with severe mental illness: an online cross-sectional survey of healthcare professionals

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    Objectives To establish healthcare professionals’ (HCPs) views about clinical roles, and the barriers and enablers to delivery of diabetes care for people with severe mental illness (SMI). Design Cross-sectional, postal and online survey. Setting Trusts within the National Health Service (NHS), mental health and diabetes charities and professional bodies. Participants HCPs who care for people with type 2 diabetes mellitus (T2DM) and/or SMI in the UK. Primary and secondary outcome measures The barriers, enablers and experiences of delivering T2DM care for people with SMI, informed by the Theoretical Domains Framework (TDF). Results Responders were 273 HCPs, primarily mental health nurses (33.7%) and psychiatrists (32.2%). Only 25% of respondents had received training in managing T2DM in people with SMI. Mental health professionals felt responsible for significantly fewer recommended diabetes care standards than physical health professionals (p<0.001). For those seeing diabetes care as part of their role, the significant barriers to its delivery in the regression analyses were a lack of knowledge (p=0.003); a need for training in communication and negotiation skills (p=0.04); a lack of optimism about the health of their clients (p=0.04) and their ability to manage T2DM in people with SMI (p=0.003); the threat of being disciplined (p=0.02); fear of working with people with a mental health condition (p=0.01); a lack of service user engagement(p=0.006) and a need for incentives (p=0.04). The significant enablers were an understanding of the need to tailor treatments (p=0.04) and goals (p=0.02) for people with SMI. Conclusions This survey indicates that despite current guidelines, diabetes care in mental health settings remains peripheral. Even when diabetes care is perceived as part of a HCP’s role, various individual and organisational barriers to delivering recommended T2DM care standards to people with SMI are experienced

    Target-Site Search of DNA-Binding Proteins

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    Identification of two distinct intron elements involved in alternative splicing of beta-tropomyosin pre-mRNA

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    The rat beta-tropomyosin gene encodes two isoforms, termed skeletal muscle beta-tropomyosin and fibroblast last tropomyosim 1 (TM-1), via an alternative RNA processing mechanism. The gene contains 11 exons. Exons 1-5 and exons 8 and 9 are common to all mRNAs expressed from the gene. Exons 6 and 11 are used in fibroblasts, as well as smooth muscle, whereas exons 7 and 10 are used only in skeletal muscle. In the present studies we focused on the mutually exclusive internal alternative splice choice involving exon 6 (fibroblast-type splice) and exon 7 (skeletal muscle-type splice). We have identified two distinct elements in the intron, upstream of exon 7, involved in splice site selection. The first element is comprised of a polypyrimidine tract located 89-143 nucleotides upstream of the 3' splice site, which specifies the location of the lariat branchpoints used, 144-153 nucleotides upstream of exon 7. The 3' splice site AG dinucleotide has no role in selection of these branchpoints. The second element is comprised of intron sequences located between the polypyrimidine tract and the 3' splice site of exon 7. It contains an important determinant in alternative splice site selection, because deletion of these sequences results in the use of the skeletal muscle-specific exon in nonmuscle cells. We propose that the use of lariat branchpoints located far upstream from a 3' splice site may be a general feature of some alternatively excised introns, reflecting the presence of regulatory sequences located between the lariat branch site and the 3' splice site. The data also indicate that alternative splicing of the rat beta-tropomyosin gene is regulated by a somewhat different mechanism from that described for rat alpha-tropomyosin gene and the transformer-2 gene of Drosophila melanogaster
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