Feminist Foreign Policies: A Governance Regime from the Global South?

Every year, more countries commit to Feminist Foreign Policies (FFPs). Most of them come from the global North; however, the emergence of FFPs in Chile, Colombia, and Mexico suggests the shape of renewed designs of global governance regimes and new struggles in the search for international status. In seeking why these countries pursue FFPs, I link different bodies of scholarship and disciplines to better understand the transformative potential of the global South FFPs. In doing so, I challenge the historical and contemporary conventional assessments of the relative unimportance of small states, the Southern region, and feminism/gender in affecting international politics and international security. In this context, the WPS framework has been a crucial component of the design of FFPs. This Agenda has consolidated the predominance of the global north perspective to address the use of sexual violence as a weapon of war. However, while for some scholars WPS represents a western global governance regime based on women\u27s economic empowerment, critical perspectives have denounced the absence of alternative and dissenting voices from the global South in producing what is considered valid knowledge. I argue this lack of diverse perspectives perpetuates the immovable categorization of women by subordinating them as subjects receiving violence and protection while limiting their transforming agency.https://digital-commons.usnwc.edu/wps/1004/thumbnail.jp

Brain Abscess as a Manifestation of Hereditary Hemorrhagic Telangiectasia in a Pediatric Patient: A Case Report

Hereditary Hemorrhagic Telangiectasia (HHT) is a disease defined by abnormal endothelial cell development thatmanifests as cutaneous telangiectasias, recurrent epistaxis, and visceral organ arteriovenous malformations. This report’s objective is to exhibit a unique presentation of an uncommon disease within the pediatric population. It also provides excellent educational value through prioritizing the investigation of alternative diagnoses in a pediatric patient who develops a brain abscess without any known risk factors. Herein we report the case of a previously healthy 17-year-old femalewho developed sudden aphasia and a newonset tonic-clonic seizure after 3 days of headache and shortness of breath. She had a past medical history of migraines and recurrent epistaxis. Imaging confirmed a ringenhancing lesion in her frontal lobe, which suggested a brain abscess. She was treated with intravenous antibiotics and steroids. Her neurological symptoms subsided and she was discharged home. Continuedwork-up revealed numerous arteriovenous malformations, which likely contributed to her brain abscess, and she was diagnosed with HHT. HHT should be suspected in pediatric patients who develop brain abscesswithout any other risk factors.Additionally, new onset neurological symptoms in pediatric patients should be investigated promptly with head imaging. Timely identification and initiation of therapy is crucial due to the high morbidity and mortality associated with brain abscess, especially in HHT patients. A 17-year-old female was transported to the emergency department after suffering from a sudden episode of inability to speak followed by a single seizure episode at school. While in her classroom, she reported a difficulty “finding words” and stood up in panic fromher desk. She approached the teacher to ask permission to leave the room. Unable to speak, she began to write on a sheet of paper, but her writing soon became incoherent to both the teacher and to herself.Her teacher sent her to the nurse’s office, where she suffered a new-onset generalized tonic- clonic seizure and the emergency medical Brain Abscess as a Manifestation of Hereditary Hemorrhagic Telangiectasia in a Pediatric Patient ¹University of South Florida College of Medicine, Tampa, FL ²Children’s Hospital at Lehigh Valley Health Network, Allentown, PA Jose M. Soto, BS¹; Tibisay Villalobos, MD² Corresponding Author: Jose M. Soto, BS, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612. Email: [email protected] The authors claim no conflicts of interest or disclosures. AMSRJ 2015; 2(1):48-53 http://dx.doi.org/10.15422/amsrj.2015.05.005 ABSTRACT CASE PRESENTATION AMSRJ 2015 Volume 2, Number 1 49 service (EMS) was called. This seizure lasted a few minutes and resolved by the time the EMS arrived. During the seizure, she also suffered an episode of epistaxis. She was able to communicate on arrival to the ED, although with some difficulty, and stated that she had a 3-day history of headaches and shortness of breath. She also reported a history of headaches since the age of twelve. She stated her headaches usually begin with an aura of “shimmering prisms and cones of lights.” The pain is typically unilateral and acetaminophen provides some relief. These headacheswere sometimes associatedwith nausea and mild photophobia. They typically resolvedwith sleep.Over the last three days, however, the headaches had worsened, and ibuprofen became ineffective. She denied any recent head trauma. Her vital signs included a blood pressure of 120/73 mmHg, heart rate of 117 beats/minute, respiratory rate of 16 breaths/minute, temperature of 99.6° Fahrenheit.On exam, she appeared anxious and in mild distress. Her cranial nerves II-XII were grossly intact, and her pupils were equally round and reactive to light. Dried blood was found in both of her nostrils; there was no active bleeding. There were no meningeal signs during her neck exam. Her cardiovascular, pulmonary, and abdominal exams were all within normal limits. Her neurological exam was also grossly normal with a Glasgow Coma Scale score of 15, but she continued having difficulty “finding words.” A complete blood count with differential was drawn: hemoglobin was 14.8 g/ dL, hematocrit was 45.7%, white blood cells were 14.8 cells/mcL (71% neutrophils, 18% lymphocytes, 6% monocytes, 5% eosinophils), and platelets were 245,000/mcL. A computed tomography (CT) scan of her head without contrast (Figure 1) showed an area of abnormally low density in the left frontal lobe that was suggestive of vasogenic edema as the grey-white matter differentiation was maintained and the edema primarily involved the white matter. No evidence of intracranial hemorrhagewas found. While air or maturing hematomas may also cause lowdensity on CT scans, thesewere ruled out due to the lack of a history of head trauma. Given the history of rapid onset neurologic symptoms and the elevated white blood cell count, as well as imaging that suggested an area of edemawithout obvious intracranial bleeding, a brain abscess was suspected. Therefore, she was admitted to the pediatric intensive care unit and started on empiric intravenous antibiotic therapy with ceftriaxone, metronidazole, and vancomycin as well as levetiracetamfor seizure prophylaxis. Amagnetic resonance imaging (MRI) scanwith and without contrast (Figures 2 and 3) confirmed an area of vasogenic edema surrounding a ring-enhancing lesion in the left frontal lobe. Themidline shift seen on the earlierCTscanwas also evident on theseMRI images.Although the differential diagnosis for ring-enhancing lesions includes glioblastoma multiforme, brain metastasis, infarct, contusion, and neurocysticerosis, Figure 1. Initial CT scan taken at presentation to the hospital showing an area suggestive of vasogenic edema in the left frontal lobe (arrow) and mild midline shift. BRIEF REPORTS BRAIN ABSCESS AMSRJ 50 2015 Volume 2, Number 1 thesewere ruled out due to history and age of the patient. A follow up magnetic resonance angiogram (MRA) of the head (Figure 4) demonstrated mass effect of the lesion on the medial cerebral artery branches on the left side, but there was no evidence of aneurysms, arteriovenous malformations, or major vessel occlusion. These findingswere also consistentwith a brain abscess. The patient continued to have headaches and six days after admission, she became increasingly confused and developed right upper extremity weakness in addition to left facial drooping. A Figure 2. T1-weighted coronalMRIwith contrast demonstrating a left sided ring-enhancing lesion (arrow) surrounded by vasogenic edema and also a midline shift. Figure 3. T2-weighted transverse MRI with contrast that highlights the area of vasogenic edema (arrow) and also further demonstrates the midline shift seen in previous images. Figure 4. Coronal MRA of the head showing mass effect of the lesion on the branches of the left middle cerebral artery (arrow). Figure 5. Repeat coronal MRI with the blue arrow pointing to the original lesion and the red arrow pointing to the new lesion. BRAIN ABSCESS BRIEF REPORTS AMSRJ 2015 Volume 2, Number 1 51 repeatMRI (Figure 5) demonstrated a new area of enhancement and diffusion restriction inferolaterally to the original lesion as well as increased vasogenic edema. The following day, she underwent a CT-guided biopsy of the original lesion with cultures. The tissue culture grew Micrococcus luteus/lylae. After the procedure, IV dexamethasone was added to her antibiotics to reduce brain tissue swelling. She continued this treatment regime for two additional weeks as her neurological symptoms began to subside. The patient was then discharged home for the remaining five weeks of IV antibiotics. During this time frame, her facial palsy resolved and she regained strength in her right upper extremity. Her headaches also improved. During her admission, itwas discovered that she had a past medical history significant for migraine headaches since the age of twelve and recurrent episodes of epistaxis. It was also revealed that her mother had hereditary hemorrhagic telangiectasia (HHT). There was a high level of suspicion forHHT due to family history and recent events, so studies of the chest to search for pulmonary arteriovenous malformations (PAVMs) aswell as a transcranialDoppler studywere performed.Numerous PAVMswere found in the patient’s left upper lobe aswell as in her right middle lobe (Figure 6). The transcranial Doppler study with agitated saline also demonstrated an arteriovenous shunt in themiddle cerebral artery. The patient met 3 of the 4 diagnostic Curacao criteria for HHT¹ (Table 1) and itwas concluded that her undiagnosedHHT had predisposed her to this brain abscess. The patient completed her IV antibiotic course and followupMRI studies demonstrated that the brain abscess had resolved. The majority of the PAVMs seen on arteriogram have since been obliterated. Figure 6. Pulmonary arteriogram demonstrating a dominant arteriovenous malformation in the inferior aspect of the upper lobe (arrow) along with numerous smaller malformations. Curacao Criteria for HHT 1. Recurrent Epistaxis 2. Telangiectasias 3. Visceral Manifestations 4. Affected 1st degree relative 3-4 criteria met: definitive HHT 2 criteria met: suspected HHT 1 criteria met: unlikely to be HHT ! Table 1. Curacao Criteria for the diagnosis of HHT BRIEF REPORTS BRAIN ABSCESS AMSRJ 52 2015 Volume 2, Number 1 Epidemiology and Pathophysiology HHT is an autosomal dominant inherited disorder that affects 1 in 10,000 people with no preference for either sex.² It is most common in the Caucasian population and is 97%penetrant.²Almost 30%of patients do not have a family history of the disease.² The genes affected by this disorder both code for Transforming Growth Factor-β receptors: ENG on chromosome 9q34.1 andACVRL-1 (activinAreceptor type IIlike 1) on chromosome 12q13.13.³ These genes are crucial in the development of vascular endothelial cells during angiogenesis and either mutation will manifest in the same manner. Clinical Manifestations The syndrome is defined by telangiectasias, or dilated post-capillary venules, of the skin, mucousmembranes and internal organs.Cutaneous telangiectasias typically occur on the face, hands, and lips. When telangiectasias occur in the nasal mucosa, they may cause spontaneous recurrent epistaxis which is the first symptom formore than 90%of patients.4,5More than 50% of patients with HHT will manifest with this symptom before the age of twenty.¹ The bleeding can be so severe that 10-30%of patientswill require blood transfusions over the course of their lifetime. In roughly 40% of patients, the gastrointestinal system is involved and can also be the source of significant blood loss.3,6 The diagnostic Curacao criteria¹ (Table 1) require three of the following four findings: recurrent epistaxis, cutaneous telangiectasias, visceral organ involvement (i.e., arteriovenous malformations thatmay bleed) and an affected firstdegree relative. Few patients, however, manifest enough signs and symptoms within the first three decades of life to meet the criteria, and therefore, it is recommended that asymptomatic children of HHT patients be genetically screened for the disease.¹ Neurological manifestations In a healthy patient, the lung capillary beds function to filter the blood before it is pumped to the brain, but pulmonary vascular malformations (PAVMs) found in HHT patients compromise this protection system.7 Large PAVMs can result in paradoxical micro-emboli entering cerebral circulation and subsequent ischemic brain injury (i.e., stroke). Abscess formation can be caused by direct seeding of pathogenic bacteria into the brain parenchyma or secondarily after an anoxic brain injury creates an environment suitable for bacteria growth. About 1% of HHT patients can develop cerebral abscess or septic meningitis, which is significantly higher than the general population.7 For the reasons noted above, PAVMs are a significant source of morbidity and mortality in HHT patients7 and they can also lead to high-output cardiac failure in later life.² Brain abscesses are usually of poly-microbial origin; only the slow growing members of the Micrococcus genuswere isolated in this case because empiric antimicrobial therapy had already begun by the time of the biopsy.8, 9 It is important to note that brain abscesses do not commonly present with the typical cardinal signs of infection: fever, leukocytosis, or positive blood cultures. 10 The neurological symptoms of brain abscesses are due in large part to the mass effect of the lesion on surrounding structures.Consequently, the symptoms can include a wide spectrum of neurologic symptoms such as aphasia, seizures, and headaches depending on the location of the lesion. HHT patients can also develop cerebral vascular malformations (CAVMs), which can manifest as various neurological symptoms. Approximately one-quarter of HHT patients DISCUSSION BRAIN ABSCESS BRIEF REPORTS AMSRJ 2015 Volume 2, Number 1 53 will have a CAVM in their lifetime and there is a 0.5%bleeding risk per year.¹ The treatment of choice for arteriovenousmalformations remains embolization of the feeding blood vessels.11 •The differential diagnosis for a pediatric patient without any known risk factors who develops a brain abscess should include HHT. •Brain abscesses are typically poly-microbial in nature and do not present with the usual signs of infection, such as fever, leukocytosis, or positive blood cultures. 1. Faughnan ME, Palda VA, Garcia-Tsao G, et al. International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia. Journal of medical genetics. 2011;48 (2):73-87. 2. Daroff R, ed. Bradley\u27s Neurology in Clinical Practice. 6th ed. Philadelphia, PA: W.B. Saunders; 2012. 3.Mark Feldman LF, Lawrence Brandt, eds. Sleisenger and Fordtran\u27s gastrointestinal and liver disease: pathophysiology, diagnosis, management. Philadelphia, PA: Saunders Elsevier; 2010. 4. Sadick H, Sadick M, Gotte K, et al. Hereditary hemorrhagic telangiectasia: an update on clinical manifestations and diagnostic measures. Wiener klinische Wochenschrift. 2006;118(3-4):72-80. 5. Murtagh B, Fulgham JR. 23-year-old woman with increasing frequency ofmigraine headaches.MayoClinic proceedings. 2002;77 (10):1105-8. 6.ChenCW, Jao SW,WuCC, et al.Red spots on the hands and red blood in the stools. Lancet. 2008;371(9619):1190. 7. Moradi M, Adeli M. Brain abscess as the first manifestation of pulmonary arteriovenous malformation: A case report. Advanced biomedical research. 2014;3:28. 8. Frazier JL, Ahn ES, Jallo GI. Management of brain abscesses in children. Neurosurgical focus. 2008;24(6):E8. 9.SelladuraiBM,SivakumaranS,AiyarS, et al. Intracranial suppuration caused by Micrococcus luteus. British journal of neurosurgery. 1993;7(2):205-7. 10. Dong SL, Reynolds SF, Steiner IP. Brain abscess in patients with hereditary hemorrhagic telangiectasia: case report and literature review. The Journal of emergency medicine. 2001;20(3):247-51. 11. Meek ME, Meek JC, Beheshti MV. Management of pulmonary arteriovenous malformations. Seminars in interventional radiology. 2011;28(1):24-31. REFERENCES LEARNING POINTS BRIEF REPORTS BRAIN ABSCES

Global environmental changes: setting priorities for Latin American coastal habitats.

The definitive version is available at www.blackwell-synergy.comThe Intergovernmental Panel for Climate Change (IPCC) reports that Global Environmental Changes (GEC) are occurring quicker than at any other time over the last 25 million years and impacting upon marine environments (Bellard et al., 2012). There is overwhelming evidence showing that GEC are affecting both the quality and quantity of the goods and services provided by a wide range of marine ecosystems. In order to discuss regional preparedness for global environmental changes, a workshop was held in Ilhabela, Brazil (22- 26 April 2012) entitled "Evaluating the Sensitivity of Central and South American Benthic Communities to Global Environmental Changes" that drew together scientists from ten Latin American and three European countries. © 2013 Blackwell Publishing Ltd

Common GBA Variants in Parkinson\u27s Disease and Lewy Body Dementia Patients

Parkinson’s disease (PD) and Lewy Body Dementias (LBD) are two distinct synucleinopathies with a great amount of symptomatic and genetic overlap. This overlap can often lead to misdiagnosis. Misdiagnosis can result in improper therapy and therefore a poorer prognosis. LBD is a neuropath diagnosis with subcategories, but for the purpose of this project we discuss LBD as a whole. GBA is a gene common to both diseases with different effect sizes in each, although increasing severity of disease for both. Common is defined as a presence greater than 1% in healthy controls. GBA is found in 2-37% of Parkinson cases worldwide, with Ashkenazi Jews having the highest frequency of mutation. Our PD cohort is a clinical series, whereas our LBD cohort is a pathological series. A clinical LBD series can skew results as they are often misdiagnosed, so there is more certainty behind a pathological series. Here, we screened ~200 samples for E365K and T408M, two common GBA variants. We have reviewed the clinical implications of being a GBA carrier for both diseases and have identified differences. We have genotyped ~1200 LBD samples for these two common variants. Now that we know GBA plays a role in each disease, we can better understand the mechanism of pathogenesis and can identify potential therapy targets for GBA carriers. These therapeutic targets could be a gateway to cures and therapies for an otherwise incurable condition

Síntomas de pacientes antes de la primera hospitalización por Síndrome Coronario Agudo

Este estudo objetivou caracterizar os pacientes quanto ao relato da presença de sintomas de dor torácica, dispneia e limitação das atividades diárias uma semana antes da primeira hospitalização por Síndrome Coronariana Aguda, segundo a forma de apresentação clínica, e compará-las. Estudo transversal, descritivo e correlacional. Utilizou-se um instrumento de avaliação clínica que investigou a presença e a gravidade dos sintomas de dispneia, precordialgia e restrição física decorrentes da isquemia do miocárdio. Com relação à limitação para realização de atividades físicas, pacientes com diagnóstico de angina instável mostraram maior comprometimento na semana que antecedeu a internação, assim como relataram a presença de dispneia e precordialgia com maior frequência do que os pacientes infartados em situações que vão desde realizarem grandes esforços como, por exemplo, caminhar na subida ou muito rápido no plano, até situações de repouso ou de pequenos esforços.The objective of this study was to characterize and compare patients regarding their report of experiencing chest pain, dyspnea and limitation of the daily life activities one week before their first hospitalization due to Acute Coronary Syndrome, according to the clinical presentation form, and compare them. This is a cross-sectional, descriptive and correlational study. A clinical evaluation instrument was used to investigate the presence and severity of dyspnea, chest pain and physical restriction due to myocardial ischemia. Regarding the limitation to carry out physical activities, patients diagnosed with unstable angina showed lower capacity the week before hospitalization, and reported experiencing dyspnea and chest pain more frequently than patients who had an infarction in situations ranging from making strong efforts, such as walking uphill or on a flat surface but very quickly, to resting and in situations of little effort.Estudio que objetivó caracterizar a pacientes en cuanto al relato de presencia de síntomas de dolor torácico, disnea y limitación de actividades diarias una semana antes de la primera hospitalización por Síndrome Coronario Agudo, según la forma de presentación clínica, y compararlas. Estudio transversal, descriptivo y correlacional. Se utilizó un instrumento de evaluación clínica que investigó la presencia y gravedad de síntomas de disnea, precordialgia y restricción física derivadas de isquemia de miocardio. En relación a limitaciones para realización de actividades físicas, pacientes con diagnóstico de angina inestable mostraron mayor compromiso en la semana que antecedió a la internación, así como relataron la presencia de disnea y precordialgia con mayor frecuencia que en los pacientes infartados en situaciones tales como realizar grandes esfuerzos como, por ejemplo, caminar en pendiente ascendiente o muy rápido en el llano, hasta situaciones de reposo o pequeños esfuerzos

MASCC/ISOO expert opinion on the management of oral problems in patients with advanced cancer

Purpose: The Palliative Care Study Group in conjunction with the Oral Care Study Group of the Multinational Association for Supportive Care in Cancer (MASCC) formed a sub-group to develop evidence-based guidance on the management of common oral problems in patients with advanced cancer. Methods: This guidance was developed in accordance with the MASCC Guidelines Policy. A search strategy for Medline was developed, and the Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials were explored for relevant reviews and trials, respectively. Guidance was categorised by the level of evidence, and “category of guideline” (i.e., “recommendation”, “suggestion” or “no guideline possible”). Results: Twelve generic suggestions (level of evidence – 5), three problem-specific recommendations and 14 problem-specific suggestions were generated. The generic suggestions relate to oral hygiene measures, assessment of problems, principles of management, re-assessment of problems and the role of dental/oral medicine professionals. Conclusions: This guidance provides a framework for the management of common oral problems in patients with advanced cancer, although every patient requires individualised management

Changes in health related quality of life 3 months after an acute coronary syndrome

BACKGROUND: The aim of the study was to identify the changes in Health Related Quality of Life (HRQL) 3 months after discharge from hospital, in patients who have had an acute coronary episode, and to determine the clinical and sociodemographic variables that explain those changes. METHODS: HRQL was assessed in 132 patients while they were admitted to the hospital and at 3 months after discharge, using the SF-36 health questionnaire. To identify the variables associated with the change, multiple linear regression models were constructed for two summary dimensions of the SF-36 (PCS and MCS) taking the change in the score of the dimension as dependent variable. RESULTS: There were no significant differences between the patients who completed the monitoring (n = 76) and those who were dropped out. After three months, a significant decrease was observed in the dimensions of physical functioning, general health, vitality, and Physical Summary Component (PCS). The variables revascularisation, age, and the interaction between previous history of coronary heart disease (CHD) and the presence of one or more risk factors explained 16.6% of the decrease in the PCS. The decrease in the PCS was 6.4 points less in the patients who had undergone revascularisation, 0.2 points less for each year of age, and 4.7 points less in the patients who had antecedents of the illness as well as one or more risk factors. CONCLUSION: The dimensions most affected at three months after an acute coronary episode were those related to the physical component. Undergoing revascularisation improved the PCS in patients, but in the younger patients and those without personal antecedents or risk factors, the PCS was affected more, perhaps due to greater expectations for recovery in these patients