Review on Therapeutic Uses of Mimosa Pudica (Touch-me-not) Plant

The prostrate or semi-erect subshrub Mimosa pudica L. (Mimosacee), referred to as touch me not, live and die, shame plant, and humble plant, is indigenous to North and South America as well as Australia. They are delicate soft grey green leaves that fold and droop at night or when handled and chilled, and they are thickly equipped with recurved thorns in India. Its peculiar bending behaviors have given it the nickname "curiosity plant." According to Ayurveda, the root of this plant is bitter, acrid, cooling, vulnerary, and alexipharmic. Leprosy, dysentery, vaginal and uterine complaints, inflammations, burning sensations, asthma, leucoderma, tiredness, and blood disorders are among the conditions it is used to treat. It appears to be a prospective herbal candidate deserving of further research, as shown by its pharmacological profile Numerous illnesses, including cancer, diabetes, hepatitis, obesity, and urinary infections, are also prevented or treated using mimosa pudica. It predominantly contains pharmacological activities that include antibacterial, antivenom, antitertility, anticonvulsant, depressant, aphrodisiac, and others. The plant has been used to treat urogenital issues for ages

Review on Calotropis Gigantea as a Topically used Plant

There have been numerous reports of the Asclepiadaceae plant, Calotropis gigantea R.Br, having medicinal and other uses. Plants have been employed as a source of medicinal substances since ancient times. In the indigenous system of medicine, plants are used extensively to treat disease. Traditional medicine makes use of various plant extracts or bioactive substances. This kind of research offers health at a reasonable price. The findings imply that the stem, leaves, and flower's phytochemical qualities can be used to treat a variety of diseases. The nation that produces the most medicinal herbs is India, which is fittingly known as the world's botanical garden. Calotropis gigantea, a member of the Asclepiadaceae/Apocynaceae family, is also referred to as the Crown Flower and has unique therapeutic properties that can be used alone or in conjunction with other medications to treat common disorders. Herbal medicines have a very wide range of medicinal applications. In ayurveda, the entire dried plant is used as a mucus explusor, parasitic worm expeller, and rejuvenator. Leprosy and asthma are treated with its dried root, while vertigo, baldness, hair loss, and rheumatoid arthritis are all treated with its latex. Calotropis is employed for a variety of conventional and homoeopathic treatments. The plant's many parts can be separated and used as medicine to get a variety of benefits

Implementation of Secure Log Management Over Cloud

A Log records are very important information which is related to activities of systems, applications or networks and these log records having various fields and their syntax. Actually logs are automatically generated on activities that are done and doing by user on system, or on any Applications such as Google Chrome or in networks. These logs are costly and need to any organization for future references such as to identify or finding any problems, to record all events, to find performance, and to investigate malicious activities in systems or networks or in application. So, protection of logs from attackers is required. Hence organization should maintain integrity, confidentiality, and security of logs. The cost to maintain logs for organizations for longer period is very less. Hence, we developed secure log management over cloud to decrease cost as well as provide security of log from attackers. To achieve this, we have done this with the help of Blowfish algorithm to Encrypt log records then SHA-1 is used to provide confidentiality while transmitting and at end point security purpose we used Shamir’s Secret sharing algorithm. DOI: 10.17762/ijritcc2321-8169.150511

ELECTRICAL ENERGY CONSERVATION IN A DISTILLERY PLANT- A CASE STUDY

Energy is a main function for each kind of process. It is the central force behind our productivity, our leisure and our environment. Energy Audit is the integral part of Energy Management. The energy audit can unearth huge profits to the industry. It quantifies the energy uses according to its various functions. It attempts to balance the total energy inputs with the output or the uses. The energy conservation and maximization strategies for a process industry like distillery plant are cost effective, which conserve the environment automatically. The electrical energy audit of a distillery plant has wide scope of energy conservation. The audit has been successfully completed and concluded with the saving of the 18500 kWh per year of energy. The most of the electrical energy is utilized to drive electrical motors used for various processes. Energy will be saving in case of motors with the help of the variable frequency drives, which reduces the speed of the motors as well as energy. The distillery has the beneficial of Rs. 1, 20,910 by implementing given recommendations

Construction of Linear Codes from the Unit Graph G(Zn)G(\mathbb{Z}_{n})

In this paper, we consider the unit graph $G(\mathbb{Z}_{n})$, where $n=p_{1}^{n_{1}} \text{ or } p_{1}^{n_{1}}p_{2}^{n_{2}} \text{ or } p_{1}^{n_{1}}p_{2}^{n_{2}}p_{3}^{n_{3}}$ and $p_{1}, p_{2}, p_{3}$ are distinct primes. For any prime $q$, we construct $q$-ary linear codes from the incidence matrix of the unit graph $G(\mathbb{Z}_{n})$ with their parameters. We also prove that the dual of the constructed codes have minimum distance either 3 or 4. Lastly, we stated two conjectures on diameter of unit graph $G(\mathbb{Z}_{n})$ and linear codes constructed from the incidence matrix of the unit graph $G(\mathbb{Z}_{n})$ for any integer $n$

Does the impact of a plant-based diet during pregnancy on birth weight differ by ethnicity? A dietary pattern analysis from a prospective Canadian birth cohort alliance

Objective: Birth weight is an indicator of newborn health and a strong predictor of health outcomes in later life. Signicant variation in diet during pregnancy between ethnic groups in high-income countries provides an ideal opportunity to investigate the influence of maternal diet on birth weight. Setting: Four multiethnic birth cohorts based in Canada (the NutriGen Alliance). Participants: 3997 full-term mother–infant pairs of diverse ethnic groups who had principal component analysis-derived diet pattern scores—plant-based, Western and health-conscious—and birth weight data. Results: No associations were identified between the Western and health-conscious diet patterns and birth weight; however, the plant-based dietary pattern was inversely associated with birth weight (β=−67.6 g per 1-unit increase; P<0.001), and an interaction with non-white ethnicity and birth weight was observed. Ethnically stratified analyses demonstrated that among white Europeans, maternal consumption of a plant-based diet associated with lower birth weight (β=−65.9 g per 1-unit increase; P<0.001), increased risk of small-for-gestational age (SGA; OR=1.46; 95% CI 1.08 to 1.54;P=0.005) and reduced risk of large-for-gestational age (LGA; OR=0.71; 95% CI 0.53 to 0.95;P=0.02). Among South Asians, maternal consumption of a plant-based diet associated with a higher birth weight (β=+40.5 g per 1-unit increase; P=0.01), partially explained by cooked vegetable consumption. Conclusions: Maternal consumption of a plant-based diet during pregnancy is associated with birth weight. Among white Europeans, a plant-based diet is associated with lower birth weight, reduced odds of an infant born LGA and increased odds of SGA, whereas among South Asians living in Canada, a plant-based diet is associated with increased birth weight

Clinicopathological Profile and Surgical Treatment of Abdominal Tuberculosis: A Single Centre Experience in Northwestern Tanzania.

Abdominal tuberculosis continues to be a major public health problem worldwide and poses diagnostic and therapeutic challenges to general surgeons practicing in resource-limited countries. This study was conducted to describe the clinicopathological profile and outcome of surgical treatment of abdominal tuberculosis in our setting and compare with what is described in literature. A prospective descriptive study of patients who presented with abdominal tuberculosis was conducted at Bugando Medical Centre (BMC) in northwestern Tanzania from January 2006 to February 2012. Ethical approval to conduct the study was obtained from relevant authorities. Statistical data analysis was performed using SPSS version 17.0. Out of 256 patients enrolled in the study, males outnumbered females. The median age was 28 years (range = 16-68 years). The majority of patients (77.3%) had primary abdominal tuberculosis. A total of 127 (49.6%) patients presented with intestinal obstruction, 106 (41.4%) with peritonitis, 17 (6.6%) with abdominal masses and 6 (2.3%) patients with multiple fistulae in ano. Forty-eight (18.8%) patients were HIV positive. A total of 212 (82.8%) patients underwent surgical treatment for abdominal tuberculosis. Bands /adhesions (58.5%) were the most common operative findings. Ileo-caecal region was the most common bowel involved in 122 (57.5%) patients. Release of adhesions and bands was the most frequent surgical procedure performed in 58.5% of cases. Complication and mortality rates were 29.7% and 18.8% respectively. The overall median length of hospital stay was 32 days and was significantly longer in patients with complications (p < 0.001). Advanced age (age ≥ 65 years), co-morbid illness, late presentation, HIV positivity and CD4+ count < 200 cells/μl were statistically significantly associated with mortality (p < 0.0001). The follow up of patients were generally poor as only 37.5% of patients were available for follow up at twelve months after discharge. Abdominal tuberculosis constitutes a major public health problem in our environment and presents a diagnostic challenge requiring a high index of clinical suspicion. Early diagnosis, early anti-tuberculous therapy and surgical treatment of the associated complications are essential for survival

Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3

Spinocerebellar ataxia type 3 (SCA3), caused by a CAG repeat expansion in the ataxin-3 gene (ATXN3), is characterized by neuronal polyglutamine (polyQ) ATXN3 protein aggregates. Although there is no cure for SCA3, gene-silencing approaches to reduce toxic polyQ ATXN3 showed promise in preclinical models. However, a major limitation in translating putative treatments for this rare disease to the clinic is the lack of pharmacodynamic markers for use in clinical trials. Here, we developed an immunoassay that readily detects polyQ ATXN3 proteins in human biological fluids and discriminates patients with SCA3 from healthy controls and individuals with other ataxias. We show that polyQ ATXN3 serves as a marker of target engagement in human fibroblasts, which may bode well for its use in clinical trials. Last, we identified a single-nucleotide polymorphism that strongly associates with the expanded allele, thus providing an exciting drug target to abrogate detrimental events initiated by mutant ATXN3. Gene-silencing strategies for several repeat diseases are well under way, and our results are expected to improve clinical trial preparedness for SCA3 therapies

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

SummaryBackground The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors—the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57·8% (95% CI 56·6–58·8) of global deaths and 41·2% (39·8–42·8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211·8 million [192·7 million to 231·1 million] global DALYs), smoking (148·6 million [134·2 million to 163·1 million]), high fasting plasma glucose (143·1 million [125·1 million to 163·5 million]), high BMI (120·1 million [83·8 million to 158·4 million]), childhood undernutrition (113·3 million [103·9 million to 123·4 million]), ambient particulate matter (103·1 million [90·8 million to 115·1 million]), high total cholesterol (88·7 million [74·6 million to 105·7 million]), household air pollution (85·6 million [66·7 million to 106·1 million]), alcohol use (85·0 million [77·2 million to 93·0 million]), and diets high in sodium (83·0 million [49·3 million to 127·5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa. Interpretation Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden. Funding Bill & Melinda Gates Foundation