Do you know this syndrome? Dyspigmentation along the Blaschko lines caused by trisomy 7 mosaicism

Dyspigmentation along the Blaschko lines is strongly suggestive of a mosaic skin disorder. We report a 9-year-old male patient who presented with swirls and streaks of both hypo and hyperpigmentation involving the entire body. Additionally, he had hypertrichosis, musculoskeletal and minor neurodevelopment abnormalities but no intellectual disability. Cultured fibroblast displayed trisomy 7 mosaicism, which can explain this pigmentary phenotype. Widespread dyspigmentation associated with involvement of other organs should prompt systemic examination to detect additional anomalies and genetic evaluation should be considered, even with normal fetal karyotype.info:eu-repo/semantics/publishedVersio

Edible Lepidoptera in Mexico: Geographic distribution, ethnicity, economic and nutritional importance for rural people

In this paper, we reported the butterflies and moths that are consumed in Mexico. We identified 67 species of Lepidoptera that are eaten principally in their larval stage in 17 states of Mexico. These species belong to 16 families: Arctiidae, Bombycidae, Castniidae, Cossidae, Geometridae, Hepialidae, Hesperiidae, Lasiocampidae, Noctuidae, Nymphalidae, Papilionidae, Pieridae, Pyralidae, Saturniidae, Sesiidae, and Sphingidae. Saturniidae, Pieridae, Noctuidae and Nymphalidae were the more species consumed with 16, 11, 9, and 8 species, respectively. The genera with the largest numbers of species were: Phassus, Phoebis, Hylesia and Spodoptera, with three species. Their local distribution, corresponding to each state of Mexico, is also presented

Predictors of Reception Efficacy in Men's U21 and Absolute World Volleyball

El objetivo de la investigación fue conocer las variables de recepción que predecían su eficacia, en diferentes niveles de juego (U-21, absoluto) en voleibol masculino. La muestra del estudio estuvo compuesta 3442 acciones de recepción, de las cuales 1894 corresponden a categoría U-21 (U-21 Men´s World Championship) y 1548 a categoría absoluta (Absolute Men´s World Championship). Las variables del estudio fueron: función del receptor, desplazamiento previo del receptor, tipo de recepción, posición del receptor, técnica de recepción, zona de recepción, eficacia de recepción. El análisis de regresión logística multinomial mostró que, el desplazamiento previo del receptor y la técnica de recepción fueron predictoras en ambas categorías, U-21 y absoluta; el tipo de recepción y zona de recepción fueron predictoras únicamente en U-21; la posición del receptor fue predictora únicamente en absoluta. Dicha información puede ayudar al proceso de entrenamiento favoreciendo el diseño de tareas concretas para cada nivel de juego.The aim of the study was to understand which variables of the reception action predict reception efficacy in two different competition categories (U-21, absolute) in male volleyball. The study sample comprised 3,442 serve-reception actions: 1,894 performed by players in U-21 category (U-21 Men´s World Championship) and 1,548 performed by players in senior category (senior Men’s World Championship). The variables considered as predictors were: receiver player, previous displacement of the receiver, type of reception, receiver position, reception technique reception zone. Logistic regression analysis showed that previous displacement of the receiver and reception technique were predictors of reception efficacy in both categories, U-21 and senior. Type of reception and reception zone were predictors of efficacy in the U-21 category, but not the senior category. Receiver position was predictive of efficacy uniquely for the senior. These may benefit the training process by favouring the design of specific tasks for each level of play

Análisis de la colocación en sets de diferente intensidad, en el U-21 men´s world championsip de voleibol

El objetivo de la presente investigación fue conocer las variables de la colocación que afectan al desarrollo del rally, en sets de diferente intensidad, en voleibol masculino U-21. La muestra del estudio estuvo compuesta por 1688 acciones de colocación que se desarrollaron en el complejo 1 (KI) (1100 en sets de intensidad alta y 588 en sets de intensidad no alta), realizadas por las cuatro selecciones mejor clasificadas en el U-21 Men´s World Championsip de voleibol. La observación correspondió a cinco partidos de cada una de las selecciones participantes. Las variables del estudio fueron: origen del colocador, zona de colocación, tipo de colocación, técnica de colocación, eficacia de colocación, zona hacia donde se envía la colocación, tiempo de colocación, desarrollo del rally, e intensidad del set. Los resultados de la regresión logística multinomial mostraron que, tanto en los sets de intensidad alta como en los de intensidad no alta, el tipo de colocación y la técnica de colocación fueron predictoras del desarrollo del rally. Además, en los sets de intensidad alta, la zona y eficacia de colocación también actuaron como predictoras del desarrollo del rally. En los sets de intensidad no alta, la zona hacia donde se envía la colocación actuó como predictora del desarrollo del rally, no siendo predictora en los sets de intensidad alta. Dichos resultados pueden ser considerados para el diseño de tareas específicas de entrenamiento de la colocación, acordes a diferentes situaciones de juego

Transient Changes in the Plasma of Astrocytic and Neuronal Injury Biomarkers in COVID-19 Patients without Neurological Syndromes

The levels of several glial and neuronal plasma biomarkers have been found to increase during the acute phase in COVID-19 patients with neurological symptoms. However, replications in patients with minor or non-neurological symptoms are needed to understand their potential as indicators of CNS injury or vulnerability. Plasma levels of glial fibrillary acidic protein (GFAP), neurofilament light chain protein (NfL), and total Tau (T-tau) were determined by Single molecule array (Simoa) immunoassays in 45 samples from COVID-19 patients in the acute phase of infection [moderate (n = 35), or severe (n = 10)] with minor or non-neurological symptoms; in 26 samples from fully recovered patients after ~2 months of clinical follow-up [moderate (n = 23), or severe (n = 3)]; and in 14 non-infected controls. Plasma levels of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), were also determined by Western blot. Patients with COVID-19 without substantial neurological symptoms had significantly higher plasma concentrations of GFAP, a marker of astrocytic activation/injury, and of NfL and T-tau, markers of axonal damage and neuronal degeneration, compared with controls. All these biomarkers were correlated in COVID-19 patients at the acute phase. Plasma GFAP, NfL and T-tau levels were all normalized after recovery. Recovery was also observed in the return to normal values of the quotient between the ACE2 fragment and circulating full-length species, following the change noticed in the acute phase of infection. None of these biomarkers displayed differences in plasma samples at the acute phase or recovery when the COVID-19 subjects were sub-grouped according to occurrence of minor symptoms at re-evaluation 3 months after the acute episode (so called post-COVID or "long COVID"), such as asthenia, myalgia/arthralgia, anosmia/ageusia, vision impairment, headache or memory loss. Our study demonstrated altered plasma GFAP, NfL and T-tau levels in COVID-19 patients without substantial neurological manifestation at the acute phase of the disease, providing a suitable indication of CNS vulnerability; but these biomarkers fail to predict the occurrence of delayed minor neurological symptoms

Efficacy and safety of lurbinectedin and doxorubicin in relapsed small cell lung cancer. Results from an expansion cohort of a phase I study

Background A phase I study found remarkable activity and manageable toxicity for doxorubicin (bolus) plus lurbinectedin (1-h intravenous [i.v.] infusion) on Day 1 every three weeks (q3wk) as second-line therapy in relapsed small cell lung cancer (SCLC). An expansion cohort further evaluated this combination. Patients and methods Twenty-eight patients with relapsed SCLC after no more than one line of cytotoxic-containing chemotherapy were treated: 18 (64%) with sensitive disease (chemotherapy-free interval [CTFI] ≥90 days) and ten (36%) with resistant disease (CTFI <90 days; including six with refractory disease [CTFI ≤30 days]). Results Ten patients showed confirmed response (overall response rate [ORR] = 36%); median progression-free survival (PFS) = 3.3 months; median overall survival (OS) = 7.9 months. ORR was 50% in sensitive disease (median PFS = 5.7 months; median OS = 11.5 months) and 10% in resistant disease (median PFS = 1.3 months; median OS = 4.6 months). The main toxicity was transient and reversible myelosuppression. Treatment-related non-hematological events (fatigue, nausea, decreased appetite, vomiting, alopecia) were mostly mild or moderate. Conclusion Doxorubicin 40 mg/m(2) and lurbinectedin 2.0 mg/m(2) on Day 1 q3wk has shown noteworthy activity in relapsed SCLC and a manageable safety profile. The combination is being evaluated as second-line therapy for SCLC in an ongoing, randomized phase III trial. Clinical trial registration www.ClinicalTrials.gov code: NCT01970540. Date of registration: 22 October, 2013

Flux moduli stabilisation, Supergravity algebras and no-go theorems

We perform a complete classification of the flux-induced 12d algebras compatible with the set of N=1 type II orientifold models that are T-duality invariant, and allowed by the symmetries of the T^6/(Z_2 x Z_2) isotropic orbifold. The classification is performed in a type IIB frame, where only H_3 and Q fluxes are present. We then study no-go theorems, formulated in a type IIA frame, on the existence of Minkowski/de Sitter (Mkw/dS) vacua. By deriving a dictionary between the sources of potential energy for the three moduli (S, T and U) in types IIA and IIB, we are able to combine algebra results and no-go theorems. The outcome is a systematic procedure for identifying phenomenologically viable models where Mkw/dS vacua may exist. We present a complete table of the allowed algebras and the viability of their resulting scalar potential, and we point at the models which stand any chance of producing a fully stable vacuum.Comment: Version published in JHE