Factores terapéuticos en dinámica grupal.

Con el presente estudio pretendemos contribuir al análisis de los factores que han intervenido en el proceso terapéutico de pacientes tratados en dinámica grupal desde su propia visión y experiencia. Para ello, nos hemos basado en las respuestas obtenidas a través de un cuestionario realizado en entrevista individual. Los pacientes pertenecían a dos grupos abiertos de terapia ambulatoria del Hospital General «Gregorio Marañón» de Madrid. La «Comprensión de sí mismo» y «Verbalización», han resultado los factores más elegidos por el conjunto de los pacientes como los de mayor utilidad en su proceso terapéutico, mientras que la «Emulación» ha sido el menos considerado. Queremos resaltar la importancia que tiene el estudio de los factores curativos en rango de utilidad desde la perspectiva del paciente a fin de que los profesionales favorezcan su aparición y la propicien en una mejor atención y comprensión del enferm

Factores terapéuticos en dinámica grupal.

Con el presente estudio pretendemos contribuir al análisis de los factores que han intervenido en el proceso terapéutico de pacientes tratados en dinámica grupal desde su propia visión y experiencia. Para ello, nos hemos basado en las respuestas obtenidas a través de un cuestionario realizado en entrevista individual. Los pacientes pertenecían a dos grupos abiertos de terapia ambulatoria del Hospital General «Gregorio Marañón» de Madrid. La «Comprensión de sí mismo» y «Verbalización», han resultado los factores más elegidos por el conjunto de los pacientes como los de mayor utilidad en su proceso terapéutico, mientras que la «Emulación» ha sido el menos considerado. Queremos resaltar la importancia que tiene el estudio de los factores curativos en rango de utilidad desde la perspectiva del paciente a fin de que los profesionales favorezcan su aparición y la propicien en una mejor atención y comprensión del enferm

Designing and evaluation of sodium selenite nanoparticles in vitro to improve selenium absorption in ruminants

Sodium selenite is used to prevent selenium deficiency known as nutritional muscular dystrophy or white muscle disease. In ruminants, selenium supplements are transformed partiality in insoluble form by ruminal microorganisms and its process decrease the selenium absorption in digestive gastrointestinal. However, the objective in this research was focused in encapsulated sodium selenite to be release into of a pH less than four, similarity to an intestinal environment. It was encapsulated by nanoprecipitation and emulsion–evaporation methods, within polymeric nanoparticles. The effect of these methods, polymer proportion (Eudragit RL and RS) and solvent (ethanol and acetone) on the physicochemical (drug entrapment, polidispersity index (PDI) and z potential) and morphological characteristics (particle morphology and particle size) were evaluated. Particle size from each nanoparticles, formulation ranged from 36.64 to 213.86 nm. Particle size, z potential and PDI increased (P ≤ 0.01) when nanoprecipitation and ethanol were used. No significant differences (P > 0.05) were observed when different polymeric proportions were used. Selenium entrapment was 26% when emulsion–evaporation method was used and 78% with nanoprecipitation. Nanoparticles produced by nanoprecipitation were spherical and had a great variation in particle size; on the other hand, nanoparticles produced by emulsion–evaporation were spherical as well as amorphous and presented a homogeneous nanopartcicle size distribution. The release of selenium from nanoparticles was higher in acid pH (less than 4), this condition may represent a better availability of the mineral in the small intestine

A particle swarm optimization approach using adaptive entropy-based fitness quantification of expert knowledge for high-level, real-time cognitive robotic control

Abstract: High-level, real-time mission control of semi-autonomous robots, deployed in remote and dynamic environments, remains a challenge. Control models, learnt from a knowledgebase, quickly become obsolete when the environment or the knowledgebase changes. This research study introduces a cognitive reasoning process, to select the optimal action, using the most relevant knowledge from the knowledgebase, subject to observed evidence. The approach in this study introduces an adaptive entropy-based set-based particle swarm algorithm (AE-SPSO) and a novel, adaptive entropy-based fitness quantification (AEFQ) algorithm for evidence-based optimization of the knowledge. The performance of the AE-SPSO and AEFQ algorithms are experimentally evaluated with two unmanned aerial vehicle (UAV) benchmark missions: (1) relocating the UAV to a charging station and (2) collecting and delivering a package. Performance is measured by inspecting the success and completeness of the mission and the accuracy of autonomous flight control. The results show that the AE-SPSO/AEFQ approach successfully finds the optimal state-transition for each mission task and that autonomous flight control is successfully achieved

Extra-uterine (abdominal) full term foetus in a 15-day pregnant rabbit

[EN] Background: While ectopic pregnancies account for 1-2% of all pregnancies, abdominal pregnancy is extremely rare, accounting for approximately 1% of ectopic pregnancies. Extrauterine abdominal pregnancy is defined as the implantation and development of an embryo in the peritoneal cavity. The present report is the first of an incidental case of abdominal pregnancy within four full-term foetus simultaneously with 2 weeks of physiological gestation in a healthy doe rabbit. Case presentation: The doe was born on November 3, 2014 and the first partum took place on May 18, 2015. The doe had previously delivered and weaned an average of 12.0 +/- 1.41 live kits at birth (no stillbirths were recorded) during 5 consecutive pregnancies. The last mating was on December 18, 2015 and the detection of pregnancy failure post breeding (by abdominal palpation) on December 31, 2015. Then, the doe was artificially inseminated on January 27, 2016, diagnosed pregnant on February 11, 2016 and subsequently euthanized to recover the foetus. A ventral midline incision revealed a reproductive tract with 12 implantation sites with 15 days old foetus and 4 term foetus in abdominal cavity. There were two foetus floating on either side of the abdominal cavity and two suspended near the greater curvature of the stomach. They were attached to internal organs by means of one or 2 thread-like blood vessels that linked them to the abdominal surfaces. Conclusions: In our opinion a systematic monitoring of rabbit breeding should be included to fully understand and enhance current knowledge of this phenomenon of abdominal pregnancy.This work was supported by Spanish Research Project AGL2014-53405-C2-1-P (Interministerial Commission on Science and Technology).Marco-Jiménez, F.; Garcia-Dominguez, X.; Valdes-Hernández, J.; Vicente Antón, JS. (2017). Extra-uterine (abdominal) full term foetus in a 15-day pregnant rabbit. BMC Veterinary Research. 13:1-4. https://doi.org/10.1186/s12917-017-1229-7S1413Petracci M, Bianchi M, Cavani C. Development of rabbit meat products fortified with n-3 polyunsaturated fatty acids. Nutrients. 2009;1:111–8.FAOSTAT (Food and Agriculture Organization of the United Nations, authors). Available online: http://faostat.fao.org/site/569/DesktopDefault.aspx?PageID=569#ancor . Accessed Sept 2012.Segura Gil P, Peris Palau B, Martínez Martínez J, Ortega Porcel J, Corpa Arenas JM. Abdominal pregnancies in farm rabbits. Theriogenology. 2004;62:642–51.Rosell JM, de la Fuente LF. Culling and mortality in breeding rabbits. Prev Vet Med. 2009;88:120–7.Tena-Betancourt E, Tena-Betancourt CA, Zúniga-Muñoz AM, Hernández-Godínez B, Ibáñez-Contreras A, Graullera-Rivera V. Multiple extrauterine pregnancy with early and near full-term mummified foetuses in a New Zealand white rabbit (Oryctolagus Cuniculus). J Am Assoc Lab Anim Sci. 2014;53:204–7.Sánchez JP, Theilgaard P, Mínguez C, Baselga M. Constitution and evaluation of a long-lived productive rabbit line. J Anim Sci. 2008;86:515–25.Savietto D, Friggens NC, Pascual JJ. Reproductive robustness differs between generalist and specialist maternal rabbit lines: the role of acquisition and allocation of resources. Genet Sel Evol. 2015;47:2.Viudes-de-Castro MP, Vicente JS. Effect of sperm count on the fertility and prolificity rates of meat rabbits. Anim Reprod Sci. 1997;46:313–9.Marco-Jiménez F, Garcia-Dominguez X, Jimenez-Trigos E, Vera-Donoso CD, Vicente JS. Vitrification of kidney precursors as a new source for organ transplantation. Cryobiology. 2015;70:278–82.Garcia-Dominguez X, Vera-Donoso CD, Jimenez-Trigos E, Vicente JS, Marco-Jimenez. First steps towards organ banks: vitrification of renal primordial. Cryo Letters. 2016;37:47–52.Arvidsson A. Extra-uterine pregnancy in a rabbit. 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Reproductive rhythm and litter weaning age as they affect rabbit doe performance and body energy balance. Anim Sci. 2005;81:289–96.Fortun-Lamothe L, De Rochambeau H, Lebas F, Tudela F. Influence of the number of suckling young on reproductive performance in intensively reared rabbits does. In: Blasco A, editor. Proceedings of the 7th world rabbit congress; 2002. p. 125–32

Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents

New treatments are needed for neglected tropical diseases (NTDs) such as Human African trypanosomiasis (HAT), Chagas disease, and schistosomiasis. Through a whole organism high-throughput screening campaign, we previously identified 797 human kinase inhibitors that grouped into 59 structural clusters and showed activity against T. brucei, the causative agent of HAT. We herein report the results of further investigation of one of these clusters consisting of substituted isatin derivatives, focusing on establishing structure-activity and -property relationship scope. We also describe their in vitro absorption, distribution, metabolism, and excretion (ADME) properties. For one isatin, NEU-4391, which offered the best activity-property profile, pharmacokinetic parameters were measured in mice