3,382 research outputs found
The photon structure function measurements from LEP
The present knowledge of the structure of the photon based on measurements of photon structure functions is discussed. This review covers QED structure functions and the hadronic structure function F_2^gamma.The present knowledge of the structure of the photon based on measurements of photon structure functions is discussed. This review covers QED structure functions and the hadronic structure function F_2^gamma
Sodium Chloride Inhibits the Growth and Infective Capacity of the Amphibian Chytrid Fungus and Increases Host Survival Rates
The amphibian chytrid fungus Batrachochytrium dendrobatidis is a recently emerged pathogen that causes the infectious disease chytridiomycosis and has been implicated as a contributing factor in the global amphibian decline. Since its discovery, research has been focused on developing various methods of mitigating the impact of chytridiomycosis on amphibian hosts but little attention has been given to the role of antifungal agents that could be added to the host's environment. Sodium chloride is a known antifungal agent used routinely in the aquaculture industry and this study investigates its potential for use as a disease management tool in amphibian conservation. The effect of 0–5 ppt NaCl on the growth, motility and survival of the chytrid fungus when grown in culture media and its effect on the growth, infection load and survivorship of infected Peron's tree frogs (Litoria peronii) in captivity, was investigated. The results reveal that these concentrations do not negatively affect the survival of the host or the pathogen. However, concentrations greater than 3 ppt significantly reduced the growth and motility of the chytrid fungus compared to 0 ppt. Concentrations of 1–4 ppt NaCl were also associated with significantly lower host infection loads while infected hosts exposed to 3 and 4 ppt NaCl were found to have significantly higher survival rates. These results support the potential for NaCl to be used as an environmentally distributed antifungal agent for the prevention of chytridiomycosis in susceptible amphibian hosts. However, further research is required to identify any negative effects of salt exposure on both target and non-target organisms prior to implementation
Accreting Neutron Stars in Low-Mass X-Ray Binary Systems
Using the Rossi X-ray Timing Explorer (RossiXTE), astronomers have discovered
that disk-accreting neutron stars with weak magnetic fields produce three
distinct types of high-frequency X-ray oscillations. These oscillations are
powered by release of the binding energy of matter falling into the strong
gravitational field of the star or by the sudden nuclear burning of matter that
has accumulated in the outermost layers of the star. The frequencies of the
oscillations reflect the orbital frequencies of gas deep in the gravitational
field of the star and/or the spin frequency of the star. These oscillations can
therefore be used to explore fundamental physics, such as strong-field gravity
and the properties of matter under extreme conditions, and important
astrophysical questions, such as the formation and evolution of millisecond
pulsars. Observations using RossiXTE have shown that some two dozen neutron
stars in low-mass X-ray binary systems have the spin rates and magnetic fields
required to become millisecond radio-emitting pulsars when accretion ceases,
but that few have spin rates above about 600 Hz. The properties of these stars
show that the paucity of spin rates greater than 600 Hz is due in part to the
magnetic braking component of the accretion torque and to the limited amount of
angular momentum that can be accreted in such systems. Further study will show
whether braking by gravitational radiation is also a factor. Analysis of the
kilohertz oscillations has provided the first evidence for the existence of the
innermost stable circular orbit around dense relativistic stars that is
predicted by strong-field general relativity. It has also greatly narrowed the
possible descriptions of ultradense matter.Comment: 22 pages, 7 figures, updated list of sources and references, to
appear in "Short-period Binary Stars: Observation, Analyses, and Results",
eds. E.F. Milone, D.A. Leahy, and D. Hobill (Dordrecht: Springer,
http://www.springerlink.com
Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis
Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites <i>Trypanosoma brucei</i> (<i>T.b.</i>) <i>gambiense</i> or <i>T.b.rhodesiense</i> and is invariably fatal if untreated. There are 60 million people at risk from the disease throughout sub-Saharan Africa. The infection progresses from the haemolymphatic stage where parasites invade the blood, lymphatics and peripheral organs, to the late encephalitic stage where they enter the central nervous system (CNS) to cause serious neurological disease. The trivalent arsenical drug melarsoprol (Arsobal) is the only currently available treatment for CNS-stage <i>T.b.rhodesiense</i> infection. However, it must be administered intravenously due to the presence of propylene glycol solvent and is associated with numerous adverse reactions. A severe post-treatment reactive encephalopathy occurs in about 10% of treated patients, half of whom die. Thus melarsoprol kills 5% of all patients receiving it. Cyclodextrins have been used to improve the solubility and reduce the toxicity of a wide variety of drugs. We therefore investigated two melarsoprol cyclodextrin inclusion complexes; melarsoprol hydroxypropyl-͎-cyclodextrin and melarsoprol randomly-methylated-β-cyclodextrin. We found that these compounds retain trypanocidal properties <i>in vitro</i> and cure CNS-stage murine infections when delivered orally, once per day for 7-days, at a dosage of 0.05 mmol/kg. No overt signs of toxicity were detected. Parasite load within the brain was rapidly reduced following treatment onset and magnetic resonance imaging showed restoration of normal blood-brain barrier integrity on completion of chemotherapy. These findings strongly suggest that complexed melarsoprol could be employed as an oral treatment for CNS-stage HAT, delivering considerable improvements over current parenteral chemotherapy
Compactification on negatively curved manifolds
We show that string/M theory compactifications to maximally symmetric
space-times using manifolds whose scalar curvature is everywhere negative, must
have significant warping, large stringy corrections, or both.Comment: 18 pages, JHEP3.cl
Increased serum neurofilament light chain concentration indicates poor outcome in Guillain-Barré syndrome
BACKGROUND
Guillain-Barré syndrome (GBS) is an autoimmune disease that results in demyelination and axonal damage. Five percent of patients die and 20% remain significantly disabled on recovery. Recovery is slow in most cases and eventual disability is difficult to predict, especially early in the disease. Blood or cerebrospinal fluid (CSF) biomarkers that could help identify patients at risk of poor outcome are required. We measured serum neurofilament light chain (sNfL) concentrations from blood taken upon admission and investigated a correlation between sNfL and clinical outcome.
METHODS
Baseline sNfL levels in 27 GBS patients were compared with a control group of 22 patients with diagnoses not suggestive of any axonal damage. Clinical outcome parameters for GBS patients included (i) the Hughes Functional Score (HFS) at admission, nadir, and discharge; (ii) the number of days hospitalised; and (iii) whether intensive care was necessary.
RESULTS
The median sNfL concentration in our GBS sample on admission was 85.5 pg/ml versus 9.1 pg/ml in controls. A twofold increase in sNfL concentration at baseline was associated with an HFS increase of 0.6 at nadir and reduced the likelihood of discharge with favourable outcome by a factor of almost three. Higher sNfL levels upon admission correlated well with hospitalisation time (rs = 0.69, p < 0.0001), during which transfer to intensive care occurred more frequently at an odds ratio of 2.4. Patients with baseline sNfL levels below 85.5 pg/ml had a 93% chance of being discharged with an unimpaired walking ability.
CONCLUSIONS
sNfL levels measured at hospital admission correlated with clinical outcome in GBS patients. These results represent amounts of acute axonal damage and reflect mechanisms resulting in disability in GBS. Thus, sNfL may serve as a convenient blood-borne biomarker to personalise patient care by identifying those at higher risk of poor outcome
Momentum asymmetries as CP violating observables
Three body decays can exhibit CP violation that arises from interfering
diagrams with different orderings of the final state particles. We construct
several momentum asymmetry observables that are accessible in a hadron collider
environment where some of the final state particles are not reconstructed and
not all the kinematic information can be extracted. We discuss the
complications that arise from the different possible production mechanisms of
the decaying particle. Examples involving heavy neutralino decays in
supersymmetric theories and heavy Majorana neutrino decays in Type-I seesaw
models are examined.Comment: 20 pages, 9 figures. Clarifying comments and one reference added,
matches published versio
Consumer exposure to biocides - identification of relevant sources and evaluation of possible health effects
<p>Abstract</p> <p>Background</p> <p>Products containing biocides are used for a variety of purposes in the home environment. To assess potential health risks, data on products containing biocides were gathered by means of a market survey, exposures were estimated using a worst case scenario approach (screening), the hazard of the active components were evaluated, and a preliminary risk assessment was conducted.</p> <p>Methods</p> <p>Information on biocide-containing products was collected by on-site research, by an internet inquiry as well as research into databases and lists of active substances. Twenty active substances were selected for detailed investigation. The products containing these substances were subsequently classified by range of application; typical concentrations were derived. Potential exposures were then estimated using a worst case scenario approach according to the European Commission's Technical Guidance Document on Risk Assessment. Relevant combinations of scenarios and active substances were identified. The toxicological data for these substances were compiled in substance dossiers. For estimating risks, the margins of exposure (MOEs) were determined.</p> <p>Results</p> <p>Numerous consumer products were found to contain biocides. However, it appeared that only a limited number of biocidal active substances or groups of biocidal active substances were being used. The lowest MOEs for dermal exposure or exposure by inhalation were obtained for the following scenarios and biocides: indoor pest control using sprays, stickers or evaporators (chlorpyrifos, dichlorvos) and spraying of disinfectants as well as cleaning of surfaces with concentrates (hydrogen peroxide, formaldehyde, glutardialdehyde). The risk from aggregate exposure to individual biocides via different exposure scenarios was higher than the highest single exposure on average by a factor of three. From the 20 biocides assessed 10 had skin-sensitizing properties. The biocides isothiazolinone (mixture of 5-chloro-2-methyl-2H-isothiazolin-3-one and 2-methyl-2H-isothiazolin-3-one, CMI/MI), glutardialdehyde, formaldehyde and chloroacetamide may be present in household products in concentrations which have induced sensitization in experimental studies.</p> <p>Conclusions</p> <p>Exposure to biocides from household products may contribute to induction of sensitization in the population. The use of biocides in consumer products should be carefully evaluated. Detailed risk assessments will become available within the framework of the EU Biocides Directive.</p
KamLAND Sensitivity to Neutrinos from Pre-Supernova Stars
In the late stages of nuclear burning for massive stars (M>8~M_{\sun}), the
production of neutrino-antineutrino pairs through various processes becomes the
dominant stellar cooling mechanism. As the star evolves, the energy of these
neutrinos increases and in the days preceding the supernova a significant
fraction of emitted electron anti-neutrinos exceeds the energy threshold for
inverse beta decay on free hydrogen. This is the golden channel for liquid
scintillator detectors because the coincidence signature allows for significant
reductions in background signals. We find that the kiloton-scale liquid
scintillator detector KamLAND can detect these pre-supernova neutrinos from a
star with a mass of 25~M_{\sun} at a distance less than 690~pc with 3
significance before the supernova. This limit is dependent on the neutrino mass
ordering and background levels. KamLAND takes data continuously and can provide
a supernova alert to the community.Comment: 19 pages, 6 figures, 1 tabl
Risk, Unexpected Uncertainty, and Estimation Uncertainty: Bayesian Learning in Unstable Settings
Recently, evidence has emerged that humans approach learning using Bayesian updating rather than (model-free) reinforcement algorithms in a six-arm restless bandit problem. Here, we investigate what this implies for human appreciation of uncertainty. In our task, a Bayesian learner distinguishes three equally salient levels of uncertainty. First, the Bayesian perceives irreducible uncertainty or risk: even knowing the payoff probabilities of a given arm, the outcome remains uncertain. Second, there is (parameter) estimation uncertainty or ambiguity: payoff probabilities are unknown and need to be estimated. Third, the outcome probabilities of the arms change: the sudden jumps are referred to as unexpected uncertainty. We document how the three levels of uncertainty evolved during the course of our experiment and how it affected the learning rate. We then zoom in on estimation uncertainty, which has been suggested to be a driving force in exploration, in spite of evidence of widespread aversion to ambiguity. Our data corroborate the latter. We discuss neural evidence that foreshadowed the ability of humans to distinguish between the three levels of uncertainty. Finally, we investigate the boundaries of human capacity to implement Bayesian learning. We repeat the experiment with different instructions, reflecting varying levels of structural uncertainty. Under this fourth notion of uncertainty, choices were no better explained by Bayesian updating than by (model-free) reinforcement learning. Exit questionnaires revealed that participants remained unaware of the presence of unexpected uncertainty and failed to acquire the right model with which to implement Bayesian updating
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