Fermi Surface Reconstruction without Breakdown of Kondo Screening at Quantum Critical Point

Motivated by recent Hall-effect experiment in YbRh$_2$Si$_2$, we study ground state properties of a Kondo lattice model in a two-dimensional square lattice using variational Monte Carlo method. We show that there are two types of phase transition, antiferromagnetic transition and topological one (Fermi surface reconstruction). In a wide region of parameters, these two transitions occur simultaneously without the breakdown of Kondo screening, accompanied by a discontinuous change of the Hall coefficient. This result is consistent with the experiment and gives a novel theoretical picture for the quantum critical point in heavy fermion systems.Comment: 4 pages, 3 figures, submitted to Physical Review Letter

Significance of Kampo, Traditional Japanese Medicine, in Supportive Care of Cancer Patients

The current standard treatment for cancer is a multidisciplinary therapy whereby various types of treatment are properly combined. Chemotherapy with multiple anticancer drugs is now common, and traditional, complementary, and alternative therapies are adopted as supportive measures. Medical care in Japan is distinguished by the ability for patients to access both Western and Kampo medical cares at the same time. There is a high degree of trust in the safety of Kampo therapies because they are practiced by medical doctors who are educated with fundamental diagnosis of Western medicine. Highly reliable clinical studies are being published, demonstrating that palliative or supportive care for cancer patients using Kampo preparations alleviates adverse effects of chemotherapy or radiotherapy. This paper reports the circumstances around cancer care in Japan where traditional therapeutic Kampo formulas are used for patients undergoing cancer treatment with cutting-edge chemotherapy, specifically to alleviate adverse effects of anticancer drugs

Resuscitation from Cardiac Arrest, Occuring During Cardiac Catheterisation : A

This is the report of a case of successful cardiac resuscitation following cardiac arrest during cardiac catheterisation, treated with brain cooling, 12 minutes having elapsed between the arrest and initiation of cardiac massage

Subjective Factors Affecting Urban Renewal in a Stagnant Satellite City

大阪市を母都市としてその周辺には，30に余る，いわゆる衛星都市群が蛸集する。これらの周辺諸都市は母都市との間において，機能的補完関係をもって分業的に並立するとともに，相互に激しい都市間競争に晒されている。本報告でとりあげる大阪府摂津市は淀川右岸の，いわゆる北摂7市の1つとして周囲に吹田，茨木，高槻など都市的水準において高位置を占める都市群に囲繞され，近年，これら諸都市との競合関係の中で，相対的な停滞性を次第に顕在化させてきた。行政，市民のいずれのレベルにおいても，一種の危機感が蔓延し，それへの対応を求める声が近時急速に盛り上がってきた。1987年，市長の諮問機関として「摂津市経済活性化懇談会」が設置されるにいたった。懇談会はその討議資料の作製を行政を介して，「関大都市問題研究会」に委託した。当研究会は1988年，1989年の両年にわたり，それぞれ性質を異にする2つの調査を実施した。本報告はこれらの調査結果を素材として当研究会が独自の問題意識と分析視角に基づき主題の追求を試みたものである。There are more than thirty satellite cities on the outskirts of Osaka. These cities are functionally in a supplemental relationship to the central city, Osaka. They also enegage in severe competition with one another. Settsu City, which we deal with in this paper, is one of the seven cities in north-Osaka. Settsu City is surrounded by cities which occupy a higher position on this urban level, and is gradually developing a relatively stagnant characteristics in the competitive relations to these cities. A sense of crisis has spread recently to the municipal authorities and to the inhabitants in Settsu as well. Public discussion, to consider how to cope with this situation, has risen remarkably. In 1987, the "Committee for Economic Activation in Settsu" was founded as a consultative organ of the mayor. The Committee entrusted to us, the "Group for the Study of Urban Problems in Kansai University", with various materials for discussion through the municipal administration. We carried out the qualitative research in 1988 and the quantitative research in 1989. This paper is a report on our inquiry into the subject. Our inquiry was based on our examination of the materials received and guided by our own concerns and our modes of analysis

The effect of a prostaglandin E-1 derivative on the symptoms and quality of life of patients with lumbar spinal stenosis

Quality of life (QOL) is a concern for patients with lumbar spinal stenosis (LSS). In this study, QOL was examined using the 5-item EuroQol (EQ-5D). QOL and activities of daily living (ADL) were surveyed for 91 patients who visited 18 medical institutions in our prefecture and were diagnosed with LSS-associated intermittent claudication. A second survey was performed after a parts per thousand yen6 weeks for 79 of the subjects to evaluate therapy with limaprost (an oral prostaglandin E1 derivative) or etodolac (an NSAID). Symptoms, maximum walking time, QOL, ADL items, and relationships among these variables were investigated for all 91 patients. Leg pain, leg numbness, and low back pain while walking were surveyed by use of VAS scores (0-100). Leg pain, leg numbness, and low back pain while walking (VAS a parts per thousand yen25) were present in 83.5, 62.6, and 54.9 % of the patients in the first survey, and approximately half of the patients had a maximum walking time 30 min, showing that maximum walking time affected health-related QOL. Of the 79 patients who completed the second survey, 56 had taken limaprost and 23 (control group) had received etodolac. Limaprost improved possible walking time, reduced ADL interference, and significantly increased the EQ-5D utility score, whereas no significant changes occurred in the control group. Maximum walking time was prolonged by a parts per thousand yen10 min and the EQ-5D utility value was improved by a parts per thousand yen0.1 points in significantly more patients in the limaprost group than in the control group. According to the findings of this survey, at an average of 8 weeks after administration limaprost improved symptoms, QOL, and ADL in LSS patients whereas treatment with an NSAID reduced pain but did not have any other effects.ArticleJOURNAL OF ORTHOPAEDIC SCIENCE. 18(2):208-215 (2013)journal articl

Activation of AMPA Receptors in the Suprachiasmatic Nucleus Phase-Shifts the Mouse Circadian Clock In Vivo and In Vitro

The glutamatergic neurotransmission in the suprachiasmatic nucleus (SCN) plays a central role in the entrainment of the circadian rhythms to environmental light-dark cycles. Although the glutamatergic effect operating via NMDAR (N-methyl D-aspartate receptor) is well elucidated, much less is known about a role of AMPAR (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor) in circadian entrainment. Here we show that, in the mouse SCN, GluR2 and GluR4 AMPAR subtypes are abundantly expressed in the retinorecipient area. In vivo microinjection of AMPA in the SCN during the early subjective night phase-delays the behavioral rhythm. In the organotypic SCN slice culture, AMPA application induces phase-dependent phase-shifts of core-clock gene transcription rhythms. These data demonstrate that activation of AMPAR is capable of phase-shifting the circadian clock both in vivo and in vitro, and are consistent with the hypothesis that activation of AMPA receptors is a critical step in the transmission of photic information to the SCN

The Hyper Suprime-Cam SSP survey: Overview and survey design

Hyper Suprime-Cam (HSC) is a wide-field imaging camera on the prime focus of the 8.2-m Subaru telescope on the summit of Mauna Kea in Hawaii. A team of scientists from Japan, Taiwan, and Princeton University is using HSC to carry out a 300-night multi-band imaging survey of the high-latitude sky. The survey includes three layers: the Wide layer will cover 1400 deg2 in five broad bands (grizy), with a 5 σ point-source depth of r ≈ 26. The Deep layer covers a total of 26 deg2 in four fields, going roughly a magnitude fainter, while the UltraDeep layer goes almost a magnitude fainter still in two pointings of HSC (a total of 3.5 deg2). Here we describe the instrument, the science goals of the survey, and the survey strategy and data processing. This paper serves as an introduction to a special issue of the Publications of the Astronomical Society of Japan, which includes a large number of technical and scientific papers describing results from the early phases of this survey

Impact of cerebrospinal fluid shunting for idiopathic normal pressure hydrocephalus on the amyloid cascade.

The aim of this study was to determine whether the improvement of cerebrospinal fluid (CSF) flow dynamics by CSF shunting, can suppress the oligomerization of amyloid β-peptide (Aβ), by measuring the levels of Alzheimer's disease (AD)-related proteins in the CSF before and after lumboperitoneal shunting. Lumbar CSF from 32 patients with idiopathic normal pressure hydrocephalus (iNPH) (samples were obtained before and 1 year after shunting), 15 patients with AD, and 12 normal controls was analyzed for AD-related proteins and APLP1-derived Aβ-like peptides (APL1β) (a surrogate marker for Aβ). We found that before shunting, individuals with iNPH had significantly lower levels of soluble amyloid precursor proteins (sAPP) and Aβ38 compared to patients with AD and normal controls. We divided the patients with iNPH into patients with favorable (improvement ≥ 1 on the modified Rankin Scale) and unfavorable (no improvement on the modified Rankin Scale) outcomes. Compared to the unfavorable outcome group, the favorable outcome group showed significant increases in Aβ38, 40, 42, and phosphorylated-tau levels after shunting. In contrast, there were no significant changes in the levels of APL1β25, 27, and 28 after shunting. After shunting, we observed positive correlations between sAPPα and sAPPβ, Aβ38 and 42, and APL1β25 and 28, with shifts from sAPPβ to sAPPα, from APL1β28 to 25, and from Aβ42 to 38 in all patients with iNPH. Our results suggest that Aβ production remained unchanged by the shunt procedure because the levels of sAPP and APL1β were unchanged. Moreover, the shift of Aβ from oligomer to monomer due to the shift of Aβ42 (easy to aggregate) to Aβ38 (difficult to aggregate), and the improvement of interstitial-fluid flow, could lead to increased Aβ levels in the CSF. Our findings suggest that the shunting procedure can delay intracerebral deposition of Aβ in patients with iNPH