Polychlorinated biphenyls in sediments of the Tam Guang-Cau Hai Lagoon, Central Vietnam

The Tam Giang-Cau Hai Lagoon, the largest in south east Asia, suffers from a great anthropogenic pressure and appears subject to a process of progressive environmental deterioration. To establish causes, history and trends of lagoon contamination, sediment samples representing three major parts of the systems were sampled and analysed for porosity, organic carbon, total nitrogen, d13C, grain size, radiotracers and PCBs. PCB surficial concentrations range from 10.2 to 24.5 lg kg1, and maximum values are close to NOAA ERL guidelines. The downcore distribution of PCBs shows two well defined peaks in the core from Tam Giang (25.5 and 16.2 lg kg1), whereas the sediment from Cau Hai is characterised by a maximum at the surface. Therefore, present trends indicate that contamination is still increasing or slightly decreasing. The prevailing congeners are 3-CB and 4-CB, hence recent PCBs appear to be mostly originated by Aroclor 1016- and 1242-like mixtures, with some samples influenced also by Aroclor 1248. Present sources seem to be similar everywhere and probably they are widespread all over the territory of the Thua Thien-Hue province

Energy Confinement in Shaped TCV Plasmas with Electron Cyclotron Heating

The effects of plasma shape on confinement and sawtooth stability are studied for positive and negative discharge triangularity and for different elongations with 1.5 MW centrally deposited ECH powe

Preliminary Confinement Studies during ECRH in TCV

Within the range of plasma shapes and plasma currents investigated, the electron confinement time, Tau_E increases with density, elongation and negative triangularity (-0.4<delta<+0.4), similar to Ohmic heating (in these low density discharges). In addition, TauEe increases with q_a up to q_a~5 after which it decreases. There is little dependence of TauEe on the heating location provided it is inside the q= I surface. As the heating location is moved outside the q=l surface, TauEe decreases. This may be the explanation of the observed decrease in TauEe at high q_a. The power-induced degradation exponent found is generally as expected: alpaha_P = -0.5

EFFECT OF LOCALISED ELECTRON CYCLOTRON HEATING ON ENERGY CONFINEMENT AND MHD IN TCV

Within the range of plasma shapes and plasma currents investigated, the electron confinement time, tau_Ee, increases with safety factor, density and negative triangularity similar to the Ohmic heating case. There is little dependence of tau_Ee on the heating location provided power deposition occurs inside the q=1 surface; as power deposition moves out of the inversion surface, tau_Ee decreases. The power-induced energy confinement degradation exponent (tau_Ee~PaP) is as usual: alpha_P ~-0.5. As a general trend, central relaxations decrease in amplitude with increasing qa, P_EC, or negative delta, in a situation where the confinement time increases

Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1

Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value &lt; 1 × 10-5) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p &lt; 1 × 10-5). In the replication sample, the lead SNP at one of these loci, rs1466535, located within intron 1 of low-density-lipoprotein receptor-related protein 1 (LRP1) demonstrated significant association (p = 0.0042). We confirmed the association of rs1466535 and AAA in our follow-up study (p = 0.035). In a combined analysis (6228 AAA and 49182 controls), rs1466535 had a consistent effect size and direction in all sample sets (combined p = 4.52 × 10-10, odds ratio 1.15 [1.10-1.21]). No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. Gene-expression studies demonstrated a trend toward increased LRP1 expression for the rs1466535 CC genotype in arterial tissues; there was a significant (p = 0.029) 1.19-fold (1.04-1.36) increase in LRP1 expression in CC homozygotes compared to TT homozygotes in aortic adventitia. Functional studies demonstrated that rs1466535 might alter a SREBP-1 binding site and influence enhancer activity at the locus. In conclusion, this study has identified a biologically plausible genetic variant associated specifically with AAA, and we suggest that this variant has a possible functional role in LRP1 expression

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article