A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer

Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident γδ cells are less well defined. In the present study, we show that human lung tissues harbor a resident Vδ1 γδ T cell population. Moreover, we demonstrate that Vδ1 T cells with resident memory and effector memory phenotypes were enriched in lung tumors compared with nontumor lung tissues. Intratumoral Vδ1 T cells possessed stem-like features and were skewed toward cytolysis and helper T cell type 1 function, akin to intratumoral natural killer and CD8+ T cells considered beneficial to the patient. Indeed, ongoing remission post-surgery was significantly associated with the numbers of CD45RA−CD27− effector memory Vδ1 T cells in tumors and, most strikingly, with the numbers of CD103+ tissue-resident Vδ1 T cells in nonmalignant lung tissues. Our findings offer basic insights into human body surface immunology that collectively support integrating Vδ1 T cell biology into immunotherapeutic strategies for nonsmall cell lung cancer

Occupational Accidents And Health-related Quality Of Life: A Study In Three Hospitals [accidentes De Trabajo Y Calidad De Vida: Un Estudio En Tres Hospitales]

This study analyzed the occurrence of occupational accidents among hospital workers between 2000 and 2005 and health-related quality of life of a sample of injured workers in 2005. Data obtained through occupational accident reports indicated 286 injured workers. In typical accidents (91.6%), accidents with piercing-cutting instruments affected 68.5% of workers. The results related to health-related quality of life obtained from 61 injured workers in 2005, through the SF-36 Medical Outcomes Study 36 - item short form health survey, evidenced high average values in most of the analyzed domains, while the lowest score observed was Vitality and Bodily Pain. No significant differences in health-related quality of life were found among injured workers from the three studied hospitals.171101107Benatti, M.C.C., (1997) Acidentes do trabalho em um hospital universitário: Um estudo sobre a ocorrência e os fatores de risco entre trabalhadores de enfermagem, , [Tese]. São Paulo (SP): Escola de Enfermagem/USPThe development of the world health organization quality of life assessment instrument (the WHOQOL) (1994) Quality of Life Assessment: International Perspectives, , Whoqol Group, In: Orley J, Kuyken W, editors, Heigelberg: Springer VerlagAuquier, P., Simeoni, M.C., Mendizabal, H., Approaches théoriques et méthodologiques de la qualité de vie a la santé (1997) Rev Prevenir, 33, pp. 77-86Ware, J.E., Sherbourne, C.D., The MOS 36- Item Short-Form Health Survey (SF-36) (1992) Med Care, 30 (6), pp. 473-83Ciconelli, R.M., Ferraz, M.B., Santos, W., Meinão, I., Quaresma, M.R., Tradução para a língua portuguesa e validação do questionário genérico de avaliação de qualidade de vida SF-36 (1999) Rev Bras Reumatol, 39 (3), pp. 143-50Nunnally, J.C., (1978) Psychometric Theory, , New York: McGraw-HillBalsamo, A.C., (2002) Estudo sobre os acidentes do trabalho com exposição aos líquidos corporais humanos em trabalhadores da saúde, , [Dissertação]. São Paulo (SP): Escola de Enfermagem/USPMarziale, M.H.P., Rodrigues, C.M., A produção científica sobre acidentes de trabalho com material perfurocortante entre trabalhadores de enfermagem (2002) Rev Latino-am Enfermagem, 10 (4), pp. 571-7. , julhoSouza, M., (1999) Acidentes ocupacionais e situações de risco para a equipe de enfermagem: Um estudo em cinco hospitais do município de São Paulo, , [Tese]. São Paulo (SP): Escola Paulista de Medicina/UNIFESPSilva, V.E.F., (1988) Estudo sobre acidentes de trabalho ocorridos com trabalhadores de enfermagem de um hospital de ensino, , São Paulo (SP): Escola de Enfermagem/USPCanini, S.R.M.S., Gir, E., Hayahida, M., Machado, A.A., Acidentes perfurocortantes entre trabalhadores de enfermagem de um hospital universitário do interior paulista (2002) Rev Latino-am Enfermagem, 10 (2), pp. 172-8. , março/abrilGurgueira, G.P., (2005) Contribuições ao estudo de qualidade de vida e restrições de trabalho em uma instituição hospitalar, , [Dissertação-Mestrado]. Campinas: Faculdade de Ciências Médicas, Universidade Estadual de CampinasOliveira, A.P.B.M., (2004) Qualidade de vida e sintomas osteomusculares em médicos de um hospital universitário, , [Dissertação-Mestrado]. Campinas: Faculdade de Ciências Médicas, Universidade Estadual de Campina