REVIEW ON EVALUATING THE ROLE OF NSAIDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

Recently, several studies have been reported that nonsteroidal anti-inflammatory drugs can fight against neurodegenerative disorders by various mechanisms. Currently, available therapies of neurodegenerative disorders (NDs) provide only symptomatic relief. This is the point at which we need an alternative that acts on the root cause of disease. Parkinson’s disease and Alzheimer’s disease are the two NDs concentrated here. Since the drug profile is already known, drug repurposing is a promising technique in research, thereby reducing the cost and period effectively. Epidemiological studies on various nonsteroidal anti-inflammatory drugs (NSAIDs) showed good results, but when it came to clinical studies the results are found to be poor. Hence, it can be concluded that NSAIDs provide its neuroprotective activity on its long-term use only, as the brain accessibility of this kind of drug is poor due to its lower lipophilicity

Studies on Mechanical Behaviour of Aluminium/Nickel Coated Silicon Carbide Reinforced Functionally Graded Composite

The aim of the work is to fabricate functionally graded aluminium (Al-Si6Cu)/ nickel coated SiC metal matrix composite using centrifugal casting route. SiC particles (53-80 µm) were coated with nickel using electroless coating technique to enhance the wettability with aluminium matrix. Several attempts were made to coat nickel on SiC by varying the process temperature (65 °C, 75 °C, and 85 °C) to obtain a uniform coating. Silicon particles coated with nickel were characterised using EDS enabled Field Emission Scanning Electron Microscope and it was found that the maximum nickel coating on SiC occurred at a process temperature of 75°C. This nickel coated SiC particles were used as the reinforcement for the manufacture of functionally graded metal matrix composite and a cast specimen of dimensions 150×90×15 mm was obtained. To ensure the graded properties in the fabricated composites, microstructure (at a distance of 1, 7 and 14 mm) and hardness (at a distance of 1, 3, 7, 10 and 14 mm) from outer periphery taken in the radial direction was analysed using Zeiss Axiovert metallurgical microscope and Vickers micro hardness tester respectively. The microstructure reveals presence of more SiC particles at the outer periphery compared to inner periphery and the hardness test shows that the hardness also decreased from outer periphery (90 HV) to inner periphery (78 HV).Tensile strength of specimen from outer zone (1-7mm) and inner zone (8-14 mm) of casting was also tested and found out a value of 153.3 Mpa and 123.3 Mpa for the outer zone and inner zone respectively. An important observation made was that the outer periphery of casting was particle rich and the inner periphery was particle deficient because of centrifugal force and variation in density between aluminium matrix and reinforcement. Functionally graded Al/SiC metal matrix composite could be extensively used in automotive industry especially in the manufacture of liners and brake drums

Rutile from ilmenite using coconut pith as reductant.

Rutile, the raw material needed for chloride route has to be prepared by removing iron from ilmenite, as rutile deposits are scarce in nature. In this study, the iron oxide present in ilmenite was reduced for different times and temperatures using coconut pith which is an agrowaste available in large quantities in Kerala. Pith has lowS, P and ash contents and has a moderate calorific value. The reduction process was studied using chemical analysis, SEM, X-ray and EPMA. Reduction of iron oxide in the ilmenite reaches a maximum at 3 to 4 h at 1040°C containing 84% of iron in the metallic state and the rest in the ferrous state. Treatment with 20% hydrochloric acid at 80°C for 1 h with stirring, leaches out most of the iron from the reduced ilmenite leaving behind only 2% iron. The SEM and X-ray data show the gradual reduction and structural changes taking place during reduction of ilmenite with coconut pit

Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh

Copyright (c) 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license