Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skin

Drug Delivery Technolog

Situation analysis of parasitological and entomological indices of onchocerciasis transmission in three drainage basins of the rain forest of South West Cameroon after a decade of ivermectin treatment

BACKGROUND: Community-Directed Treatment with Ivermectin (CDTI) is the main strategy adopted by the African Programme for Onchocerciasis control (APOC). Recent reports from onchocerciasis endemic areas of savannah zones have demonstrated the feasibility of disease elimination through CDTI. Such information is lacking in rain forest zones. In this study, we investigated the parasitological and entomological indices of onchocerciasis transmission in three drainage basins in the rain forest area of Cameroon [after over a decade of CDTI]. River basins differed in terms of river number and their flow rates; and were characterized by high pre-control prevalence rates (60-98%). METHODS: Nodule palpation and skin snipping were carried out in the study communities to determine the nodule rates, microfilarial prevalences and intensity. Simulium flies were caught at capture points and dissected to determine the biting, parous, infection and infective rates and the transmission potential. RESULTS: The highest mean microfilaria (mf) prevalence was recorded in the Meme (52.7%), followed by Mungo (41.0%) and Manyu drainage basin (33.0%). The same trend was seen with nodule prevalence between the drainage basins. Twenty-three (23/39) communities (among which 13 in the Meme) still had mf prevalence above 40%. All the communities surveyed had community microfilarial loads (CMFL) below 10 mf/skin snip (ss). The infection was more intense in the Mungo and Meme. The intensity of infection was still high in younger individuals and children less than 10 years of age. Transmission potentials as high as 1211.7 infective larvae/person/month were found in some of the study communities. Entomological indices followed the same trend as the parasitological indices in the three river basins with the Meme having the highest values. CONCLUSION: When compared with pre-control data, results of the present study show that after over a decade of CDTI, the burden of onchocerciasis has reduced. However, transmission is still going on in this study site where loiasis and onchocerciasis are co-endemic and where ecological factors strongly favour the onchocerciasis transmission. The possible reasons for this persistent and differential transmission despite over a decade of control efforts using ivermectin are discussed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13071-015-0817-2) contains supplementary material, which is available to authorized users

Hydrophilic polymer changes the water demand in the implementation of a dwarf cashew orchard.

Abstract: Important losses of dwarf cashew seedlings during the establishment of orchards in the Brazilian semiarid are related to the relatively short rainy season. This study aimed to evaluate biochar and hydrophilic polymer as soil amendments to increase water retention and reduce plant death in the first year. An experiment was conducted at the Curu Station, Paraipaba, CE, Brazil, using the clone BRS 226. The experimental design consisted of randomized blocks, with amounts of 0.5, 1.0, 2.0, and 4.0 kg of cashew wood biochar and 20, 40, 60, 80 g of hydrophilic polymer applied per pit, as well as a control treatment (no soil amendment). Seedlings were submitted to an irrigation regime to avoid water stress (5 L water seedling-1 when the tensiometer installed at a depth of 0.15 m reached 60 kPa). The variables of plant development number of leaves, plant height, stem diameter, and canopy diameter were evaluated up to 374 days after transplanting to the field. The analysis of variance showed no treatment effect on plant development. However, minimum water consumption was observed when 29.56 g of hydrophilic polymer was applied per pit, providing 100.0% seedling survival