899 research outputs found
Electric and magnetic charges in N=2 conformal supergravity theories
General Lagrangians are constructed for N=2 conformal supergravity theories
in four space-time dimensions involving gauge groups with abelian and/or
non-abelian electric and magnetic charges. The charges are encoded in the gauge
group embedding tensor. The scalar potential induced by the gauge interactions
is quadratic in this tensor, and, when the embedding tensor is treated as a
spurionic quantity, it is formally covariant with respect to electric/magnetic
duality. This work establishes a general framework for studying any deformation
induced by gauge interactions of matter-coupled N=2 supergravity theories. As
an application, full and residual supersymmetry realizations in maximally
symmetric space-times are reviewed. Furthermore, a general classification is
presented of supersymmetric solutions in
space-times. As it turns out, these solutions allow either eight or four
supersymmetries. With four supersymmetries, the spinorial parameters are
Killing spinors of that are constant on , so that they
carry no spin, while the bosonic background is rotationally invariant.Comment: 49 pages, typos correcte
All solutions of the localization equations for N=2 quantum black hole entropy
We find the most general bosonic solution to the localization equations
describing the contributions to the quantum entropy of supersymmetric black
holes in four-dimensional N=2 supergravity coupled to n_v vector multiplets.
This requires the analysis of the BPS equations of the corresponding off-shell
supergravity (including fluctuations of the auxiliary fields) with AdS2 \times
S2 attractor boundary conditions. Our work completes and extends the results of
arXiv:1012.0265 that were obtained for the vector multiplet sector, to include
the fluctuations of all the fields of the off-shell supergravity. We find that,
when the auxiliary SU(2) gauge field strength vanishes, the most general
supersymmetric configuration preserving four supercharges is labelled by n_v+1
real parameters corresponding to the excitations of the conformal mode of the
graviton and the scalars of the n_v vector multiplets. In the general case, the
localization manifold is labelled by an additional SU(2) triplet of one-forms
and a scalar function.Comment: 27 page
BPS black holes in N=2 D=4 gauged supergravities
We construct and analyze BPS black hole solutions in gauged N=2, D=4
supergravity with charged hypermultiplets. A class of solutions can be found
through spontaneous symmetry breaking in vacua that preserve maximal
supersymmetry. The resulting black holes do not carry any hair for the scalars.
We demonstrate this with explicit examples of both asymptotically flat and
anti-de Sitter black holes. Next, we analyze the BPS conditions for
asymptotically flat black holes with scalar hair and spherical or axial
symmetry. We find solutions only in cases when the metric contains ripples and
the vector multiplet scalars become ghost-like. We give explicit examples that
can be analyzed numerically. Finally, we comment on a way to circumvent the
ghost-problem by introducing also fermionic hair.Comment: 40 pages, 2 figures; v2 references added; v3 minor changes, published
versio
Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza virus that expresses an altered nucleoprotein sequence
Influenza virus poses a difficult challenge for protective immunity. This virus is adept at altering its surface proteins, the proteins that are the targets of neutralizing antibody. Consequently, each year a new vaccine must be developed to combat the current recirculating strains. A universal influenza vaccine that primes specific memory cells that recognise conserved parts of the virus could prove to be effective against both annual influenza variants and newly emergent potentially pandemic strains. Such a vaccine will have to contain a safe and effective adjuvant that can be used in individuals of all ages. We examine protection from viral challenge in mice vaccinated with the nucleoprotein from the PR8 strain of influenza A, a protein that is highly conserved across viral subtypes. Vaccination with nucleoprotein delivered with a universally used and safe adjuvant, composed of insoluble aluminium salts, provides protection against viruses that either express the same or an altered version of nucleoprotein. This protection correlated with the presence of nucleoprotein specific CD8 T cells in the lungs of infected animals at early time points after infection. In contrast, immunization with NP delivered with alum and the detoxified LPS adjuvant, monophosphoryl lipid A, provided some protection to the homologous viral strain but no protection against infection by influenza expressing a variant nucleoprotein. Together, these data point towards a vaccine solution for all influenza A subtypes
All the timelike supersymmetric solutions of all ungauged d=4 supergravities
We determine the form of all timelike supersymmetric solutions of all N
greater or equal than 2, d=4 ungauged supergravities, for N less or equal than
4 coupled to vector supermultiplets, using the $Usp(n+1,n+1)-symmetric
formulation of Andrianopoli, D'Auria and Ferrara and the spinor-bilinears
method, while preserving the global symmetries of the theories all the way. As
previously conjectured in the literature, the supersymmetric solutions are
always associated to a truncation to an N=2 theory that may include
hypermultiplets, although fields which are eliminated in the truncations can
have non-trivial values, as is required by the preservation of the global
symmetry of the theories. The solutions are determined by a number of
independent functions, harmonic in transverse space, which is twice the number
of vector fields of the theory (n+1). The transverse space is flat if an only
if the would-be hyperscalars of the associated N=2 truncation are trivial.Comment: v3: Some changes in the introduction. Version to be published in JHE
The Enhancement of Proton Stochastic Heating in the Near-Sun Solar Wind
International audienceStochastic heating (SH) is a nonlinear heating mechanism driven by the violation of magnetic moment invariance due to large-amplitude turbulent fluctuations producing diffusion of ions toward higher kinetic energies in the direction perpendicular to the magnetic field. It is frequently invoked as a mechanism responsible for the heating of ions in the solar wind. Here, we quantify for the first time the proton SH rate Q(perpendicular to) at radial distances from the Sun as close as 0.16 au, using measurements from the first two Parker Solar Probe encounters. Our results for both the amplitude and radial trend of the heating rate, Q(perpendicular to) proportional to r(-2.5), agree with previous results based on the Helios data set at heliocentric distances from 0.3 to 0.9 au. Also in agreement with previous results, Q(perpendicular to) is significantly larger in the fast solar wind than in the slow solar wind. We identify the tendency in fast solar wind for cuts of the core proton velocity distribution transverse to the magnetic field to exhibit a flattop shape. The observed distribution agrees with previous theoretical predictions for fast solar wind where SH is the dominant heating mechanism
Effectiveness and costs of implementation strategies to reduce acid suppressive drug prescriptions: a systematic review
<p>Abstract</p> <p>Background</p> <p>Evaluation of evidence for the effectiveness of implementation strategies aimed at reducing prescriptions for the use of acid suppressive drugs (ASD).</p> <p>Methods</p> <p>A systematic review of intervention studies with a design according to research quality criteria and outcomes related to the effect of reduction of ASD medication retrieved from Medline, Embase and the Cochrane Library. Outcome measures were the strategy of intervention, quality of methodology and results of treatment to differences of ASD prescriptions and costs.</p> <p>Results</p> <p>The intervention varied from a single passive method to multiple active interactions with GPs. Reports of study quality had shortcomings on subjects of data-analysis. Not all outcomes were calculated but if so rction of prescriptions varied from 8% up to 40% and the cost effectiveness was in some cases negative and in others positive. Few studies demonstrated good effects from the interventions to reduce ASD.</p> <p>Conclusion</p> <p>Poor quality of some studies is limiting the evidence for effective interventions. Also it is difficult to compare cost-effectiveness between studies. However, RCT studies demonstrate that active interventions are required to reduce ASD volume. Larger multi-intervention studies are necessary to evaluate the most successful intervention instruments.</p
Comparação entre microssatĂ©lites e o gene Ml MntH como alvos para a identificação do Mycobacterium leprae por PCR na hansenĂase
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