16 research outputs found
Release of platelet activation markers during coronary angioplasty
Background Authors of several studies have reported that activation of
platelets occurs during coronary angioplasty, but consistent results
have not been obtained. Levels of serotonin in coronary circulation have
been found to be elevated during percutaneous transluminal coronary
angioplasty but greater than normal concentrations of
beta-thromboglobulin and platelet factor 4 have not been detected.
Objective To perform a serial analysis of platelet-activation markers
with simultaneous measurements of revels of serotonin,
beta-thromboglobulin and platelet factor 4 in blood samples from the
coronary artery and coronary sinus of patients undergoing coronary
angioplasty.
Methods Twenty patients undergoing elective coronary angioplasty were
studied. Measurements of levels of beta-thromboglobulin, platelet factor
4, and serotonin in samples from the ostium of the coronary artery and
the coronary sinus were performed immediately before angioplasty and
after the first balloon deflation.
Results Concentrations of beta-thromboglobulin and platelet factor 4 in
coronary artery and coronary sinus were elevated in all patients before
dilatation, whereas concentrations of serotonin were elevated in 85% of
the patients. Concentrations of all markers in coronary sinus decreased
after the first inflation. The coronary-sinus: coronary-artery
concentration ratios before dilatation for beta-thromboglobulin,
platelet factor 4, and serotonin were >1 for the majority of patients,
particularly for those with complex culprit lesions, indicating that
coronary activation of platelets was occurring. Ratios remained
unchanged or decreased after the first inflation, depending on initial
values.
Conclusions Both systemic and coronary activation occur in patients
subjected to percutaneous transluminal coronary angioplasty before the
onset of intervention. After balloon deflation the greater than normal
baseline coronary-sinus: coronary-artery concentration ratios of ail
markers (beta-thromboglobulin, platelet factor 4 and serotonin) tend to
decline or remain unchanged, depending on the level of activation. Coron
Artery Dis 11:391-398 (C) 2000 Lippincott Williams & Wilkins