The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration.

Cell migration drives cell invasion and metastatic progression in prostate cancer and is a major cause of mortality and morbidity. However the mechanisms driving cell migration in prostate cancer patients are not fully understood. We previously identified the cancer-associated cell migration protein Tetraspanin 1 (TSPAN1) as a clinically relevant androgen regulated target in prostate cancer. Here we find that TSPAN1 is acutely induced by androgens, and is significantly upregulated in prostate cancer relative to both normal prostate tissue and benign prostate hyperplasia (BPH). We also show for the first time, that TSPAN1 expression in prostate cancer cells controls the expression of key proteins involved in cell migration. Stable upregulation of TSPAN1 in both DU145 and PC3 cells significantly increased cell migration and induced the expression of the mesenchymal markers SLUG and ARF6. Our data suggest TSPAN1 is an androgen-driven contributor to cell survival and motility in prostate cancer.This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site

SERUM-LIPIDS, LIPOPROTEINS AND APOLIPOPROTEINS IN UNTREATED ESSENTIAL-HYPERTENSION

WOS: A1993LG99000019PubMed ID: 8345503

#Demonetization and Its Impact on the Indian Economy – Insights from Social Media Analytics

Part 4: Social Media and Web 3.0 for SmartnessInternational audienceIn recent times, twitter has emerged as a central site where people express their views and opinions on happenings surrounding their lives. This paper tries to study the general public sentiment surrounding a major breakthrough event for the Indian economy i.e. demonetization by capturing 1,44,497 tweets about demonetization. The paper also tries to find the impact of demonetization on various sectors of the economy and whether there exists any correlation between the public sentiments expressed over twitter and the stock market performance of Nifty 50 companies. The industries were classified into cash dependent and independent sectors and the impact on both were separately studied. It was found there exists no significant correlation between the sentiments expressed over twitter about demonetization and the performance of various sectors in the economy and twitter sentiments alone do not necessarily predict the performance of financial market