Homozygous microdeletion of exon 5 in ZNF277 in a girl with specific language impairment

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Mitochondrial Mutations in Adenoid Cystic Carcinoma of the Salivary Glands

Background: The MitoChip v2.0 resequencing array is an array-based technique allowing for accurate and complete sequencing of the mitochondrial genome. No studies have investigated mitochondrial mutation in salivary gland adenoid cystic carcinomas. Methodology: The entire mitochondrial genome of 22 salivary gland adenoid cystic carcinomas (ACC) of salivary glands and matched leukocyte DNA was sequenced to determine the frequency and distribution of mitochondrial mutations in ACC tumors. Principal Findings: Seventeen of 22 ACCs (77%) carried mitochondrial mutations, ranging in number from 1 to 37 mutations. A disproportionate number of mutations occurred in the D-loop. Twelve of 17 tumors (70.6%) carried mutations resulting in amino acid changes of translated proteins. Nine of 17 tumors (52.9%) with a mutation carried an amino acid changing mutation in the nicotinamide adenine dinucleotide dehydrogenase (NADH) complex. Conclusions/Significance: Mitochondrial mutation is frequent in salivary ACCs. The high incidence of amino acid changing mutations implicates alterations in aerobic respiration in ACC carcinogenesis. D-loop mutations are of unclear significance

Laboratory development of Dermacentor marginatus ticks (Acari: Ixodidae) at two temperatures

The influence of two temperatures on the development of Dermacentor marginatus evolutive cycle was studied. Tests performed under controlled laboratory conditions at 21 A degrees C, 80 % RH and 27 A degrees C, RH 80 %, on ten fully engorged female ticks collected from naturally infested goats, in Cluj County, Romania. Hatched larvae were fed on white mice and the nymphs and adults on guinea pigs. The following parameters were evaluated: egg incubation; pre-feeding, feeding and pre-moulting for larvae and nymphs; pre-feeding, feeding, pre-oviposition and oviposition for females. Significant differences (p < 0.001) were observed in: egg incubation period (29.4 +/- A 1.07 at 21 A degrees C; 5.9 +/- A 0.73 at 27 A degrees C) and pre-moulting duration of larvae (18.9 +/- A 1.02 at 21 A degrees C; 6.1 +/- A 0.58 at 27 A degrees C) and nymphs (21.3 +/- A 0.87 at 21 A degrees C; 19.9 +/- A 0.71 at 27 A degrees C). The average duration of the developmental cycle was 133.9 days (range 122-154 days) at 21 A degrees C, and 94.2 days (range 83-111 days) at 27 A degrees C

A Comparative Analysis of Temporal Changes in Urban Land Use Resorting to Advanced Remote Sensing and GIS in Karaj, Iran and Luxor, Egypt

As many developing countries, Iranian and Egyptian cities are growing in population and physically expanding at a high rate. The uncontrolled scattered construction causes loss of orchards, agricultural lands as well as spatial chaos, traffic congestion and increasing costs of municipal services. As a consequence, this also induces a loss of identity and social characteristics of neighborhoods, poor quality of life and degradation of natural landscapes, etc. To face with these issues, it is important to quantify trend and the rate of land cover conversion in order to support plan for a rational land use policy. The main purpose of this research is to set up low cost and reliable tools useful for the monitoring of the urban growth. In this paper, multi-temporal satellite data (Landsat TM 1984, Landsat TM 1998 and L8 2016) have been analyzed for investigating and assessing the effects of the urban expansion in Karaj (Iran) and Luxor (Egypt). According to the results obtained from change detection analysis, both of the investigated sites clearly exhibit an increasing trend in urban expansion much more evident in the case of Luxor than Karaj area. The integration between remote sensing and GIS and the joint use of analytical methods for quantitative-qualitative assessment enable the identification of changes and the mapping of new planned and unplanned urban construction. The availability of timely information free available from NASA web site and the data processing herein adopted provide useful information for supporting planning and sustainable developing policies