44 research outputs found
Real Property Transactions in the Network Society: Platform Real Estate, Housing Hactivism, and the Re-scaling of Public and Private Power
Technology is rapidly transforming the landscape of land ownership and housing transactions, creating new types of consumer risk and new regulatory challenges. As markets, legal systems, and housing consumers navigate the new opportunities and risks of βplatform real estateβ (or βPropTechβ), the underlying land laws, policies, and practices that produce the material context and legal framework for real property transactions, and against which consumer risk and regulation must be understood, require βre-scaling.β In this article, we offer a theoretical framework for this re-scaling project, drawing on our earlier work to develop Resilient Property Theory (RPT) for analysing complex, large-scale property questions using methods thatβin a departure from liberal property theoriesβpay attention to the public role of the state. Against a backdrop in which narratives of private property law defined real property transactions as βprivate realmβ activities, while consumer law and policy provided the vehicle for state-backed regulation of specifically defined transactions based on a risk-based approach, this article brings the state back into view to reflect on new configurations of risk in consumer housing transactions. In the de-materialized realm of the βnetwork society,β networks, platforms, and innovations are recalibrating housing transactions. In this data-driven world, land transactions are financialized, depersonalized, and increasingly remote from the materiality of land and the consumption of housing. As new capabilities in digital land transaction systems reach back into the underlying law of ownership, official (state), insider (global capital markets), and outsider (social movement activists) networks have evolved to leverage their relative positionality. This article uses techniques developed in RPT to examine the re-scaling of risk in real property and housing transactions through digital network technologies. We consider the implications of resilience needs in the network society in relation to the public sovereignty of the state, the private sovereignty of land ownership, and practices of resistance to public and private sovereignty through βhousing hacktivism.β Finally, we argue that conceptions of consumer vulnerability and risk and embedded ideas about the relationships between private property law and consumer law and policy in real property transactions must evolve to take account of these effects
IL-17 Expression in the Time Course of Acute Anti-Thy1 Glomerulonephritis
Background Interleukin-17 (IL-17) is a new pro-inflammatory cytokine involved
in immune response and inflammatory disease. The main source of IL-17 is a
subset of CD4+ T-helper cells, but is also secreted by non-immune cells. The
present study analyzes expression of IL-17 in the time course of acute anti-
thy1 glomerulonephritis and the role of IL-17 as a potential link between
inflammation and fibrosis. Methods Anti-thy1 glomerulonephritis was induced
into male Wistar rats by OX-7 antibody injection. After that, samples were
taken on days 1, 5, 10 (matrix expansion phase), 15 and 20 (resolution phase).
PBS-injected animals served as controls. Proteinuria and histological matrixes
score served as the main markers for disease severity. In in vitro
experiments, NRK-52E cells were used. For cytokine expressions, mRNA and
protein levels were analyzed by utilizing RT-PCR, in situ hybridization and
immunofluorescence. Results Highest IL-17 mRNA-expression (6.50-fold vs. con;
p<0.05) was found on day 5 after induction of anti-thy1 glomerulonephritis
along the maximum levels of proteinuria (113 Β± 13 mg/d; p<0.001), histological
glomerular-matrix accumulation (82%; p<0.001) and TGF-Ξ²1 (2.2-fold; p<0.05),
IL-6 mRNA expression (36-fold; p<0.05). IL-17 protein expression co-localized
with the endothelial cell marker PECAM in immunofluorescence. In NRK-52E
cells, co-administration of TGF-Ξ²1 and IL-6 synergistically up-regulated IL-17
mRNA 4986-fold (p<0.001). Conclusions The pro-inflammatory cytokine IL-17 is
up-regulated in endothelial cells during the time course of acute anti-thy1
glomerulonephritis. In vitro, NRK-52E cells secrete IL-17 under pro-fibrotic
and pro-inflammatory conditions
Th17 Cytokines and the Gut Mucosal Barrier
Local immune responses serve to contain infections by pathogens to the gut while preventing pathogen dissemination to systemic sites. Several subsets of T cells in the gut (T-helper 17 cells, Ξ³Ξ΄ T cells, natural killer (NK), and NK-T cells) contribute to the mucosal response to pathogens by secreting a subset of cytokines including interleukin (IL)-17A, IL-17F, IL-22, and IL-26. These cytokines induce the secretion of chemokines and antimicrobial proteins, thereby orchestrating the mucosal barrier against gastrointestinal pathogens. While the mucosal barrier prevents bacterial dissemination from the gut, it also promotes colonization by pathogens that are resistant to some of the inducible antimicrobial responses. In this review, we describe the contribution of Th17 cytokines to the gut mucosal barrier during bacterial infections
CD27 is a thymic determinant of the balance between interferon-gamma-and interleukin 17-producing gamma delta T cell subsets
The production of cytokines such as interferon-gamma and interleukin 17 by alphabeta and gammadelta T cells influences the outcome of immune responses. Here we show that most gammadelta T lymphocytes expressed the tumor necrosis factor receptor family member CD27 and secreted interferon-gamma, whereas interleukin 17 production was restricted to CD27(-) gammadelta T cells. In contrast to the apparent plasticity of alphabeta T cells, the cytokine profiles of these distinct gammadelta T cell subsets were essentially stable, even during infection. These phenotypes were established during thymic development, when CD27 functions as a regulator of the differentiation of gammadelta T cells at least in part by inducing expression of the lymphotoxin-beta receptor and genes associated with trans-conditioning and interferon-gamma production. Thus, the cytokine profiles of peripheral gammadelta T cells are predetermined mainly by a mechanism involving CD2