5,481 research outputs found
Factores que inciden en la prĂĄctica de actividad fĂsica de la poblaciĂłn en situaciĂłn de discapacidad
El presente documento es el resumen de la propuesta tĂ©cnica del proyecto de investigaciĂłn denominado Determinantes de la prĂĄctica de actividad fĂsica en personas con discapacidad, sus familias, cuidadoras y cuidadores en BogotĂĄ, fruto de la apuesta acadĂ©mica desarrollada por un equipo de investigadoras de los grupos de investigaciĂłn en Actividad FĂsica y Desarrollo Humano, y en RehabilitaciĂłn e IntegraciĂłn Social de la Persona con Discapacidad, de la Facultad de RehabilitaciĂłn y Desarrollo Humano, de la Universidad del Rosario.
El proyecto de investigaciĂłn obtuvo la financiaciĂłn del Fondo de Investigaciones de la Universidad del Rosario (FIUR), para ser desarrollado durante el perĂodo de julio de 2008 a junio de 2009
Uniportal robotic-assisted thoracic surgery for mediastinal tumors
info:eu-repo/semantics/publishedVersio
The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy
Background: Hypertrophic (HCM) and dilated (DCM) cardiomyopathies results from sarcomeric protein mutations, including cardiac troponin T (cTnT, TNNT2). We determined whether TNNT2 mutations cause cardiomyopathies by altering cTnT function or quantity; whether the severity of DCM is related to the ratio of mutant to wildtype cTnT; whether Ca2+ desensitization occurs in DCM; and whether absence of cTnT impairs early embryonic cardiogenesis. Methods and Findings: We ablated Tnnt2 to produce heterozygous Tnnt2+/ mice, and crossbreeding produced homozygous null Tnnt2-/-embryos. We also generated transgenic mice overexpressing wildtype (TGWT) or DCM mutant (TGK210Î) Tnnt2. Crossbreeding produced mice lacking one allele of Tnnt2, but carrying wildtype (Tnnt2+/-/TGWT) or mutant (Tnnt2+/-/TGK210Î) transgenes. Tnnt2+/-mice relative to wildtype had significantly reduced transcript (0.82 ± 0.06 [SD] vs. 1.00 ± 0.12 arbitrary units; p = 0.025), but not protein (1.01 ± 0.20 vs. 1.00 ± 0.13 arbitrary units; p = 0.44). Tnnt2+/-mice had normal hearts (histology, mass, left ventricular end diastolic diameter [LVEDD], fractional shortening [FS]). Moreover, whereas Tnnt2+/-/ TGK210Î mice had severe DCM, TGK210Î mice had only mild DCM (FS 18 ± 4 vs. 29 ± 7%; p < 0.01). The difference in severity of DCM may be attributable to a greater ratio of mutant to wildtype Tnnt2 transcript in Tnnt2+/-/TGK210Î relative to TGK210Î mice (2.42±0.08, p = 0.03). Tnnt2+/-/TGK210Î muscle showed Ca2+ desensitization (pCa50 = 5.34 ± 0.08 vs. 5.58 ± 0.03 at sarcomere length 1.9 ÎŒm. p<0.01), but no difference in maximum force generation. Day 9.5 Tnnt2-/-embryos had normally looped hearts, but thin ventricular walls, large pericardial effusions, noncontractile hearts, and severely disorganized sarcomeres. Conclusions: Absence of one Tnnt2 allele leads to a mild deficit in transcript but not protein, leading to a normal cardiac phenotype. DCM results from abnormal function of a mutant protein, which is associated with myocyte Ca2+ desensitization. The severity of DCM depends on the ratio of mutant to wildtype Tnnt2 transcript. cTnT is essential for sarcomere formation, but normal embryonic heart looping occurs without contractile activity. © 2008 Ahmad et al
The morbidity of urethral stricture disease among male Medicare beneficiaries
<p>Abstract</p> <p>Background</p> <p>To date, the morbidity of urethral stricture disease among American men has not been analyzed using national datasets. We sought to analyze the morbidity of urethral stricture disease by measuring the rates of urinary tract infections and urinary incontinence among men with a diagnosis of urethral stricture.</p> <p>Methods</p> <p>We analyzed Medicare claims data for 1992, 1995, 1998, and 2001 to estimate the rate of dual diagnoses of urethral stricture with urinary tract infection and with urinary incontinence occurring in the same year among a 5% sample of beneficiaries. Male Medicare beneficiaries receiving co-incident ICD-9 codes indicating diagnoses of urethral stricture and either urinary tract infection or urinary incontinence within the same year were counted.</p> <p>Results</p> <p>The percentage of male patients with a diagnosis of urethral stricture who also were diagnosed with a urinary tract infection was 42% in 2001, an increase from 35% in 1992. Eleven percent of male Medicare beneficiaries with urethral stricture disease in 2001 were diagnosed with urinary incontinence in the same year. This represents an increase from 8% in 1992.</p> <p>Conclusions</p> <p>Among male Medicare beneficiaries diagnosed with urethral stricture disease in 2001, 42% were also diagnosed with a urinary tract infection, and 11% with incontinence. Although the overall incidence of stricture disease decreased over this time period, these rates of dual diagnoses increased from 1992 to 2001. Our findings shed light into the health burden of stricture disease on American men. In order to decrease the morbidity of stricture disease, early definitive management of strictures is warranted.</p
Uniportal pure robotic-assisted thoracic surgeryâtechnical aspects, tips and tricks
The uniportal access for robotic thoracic surgery presents itself as a natural evolution of minimally invasive thoracic surgery (MITS). It was developed by surgeons who pioneered the uniportal video-assisted thoracic surgery (U-VATS) in all its aspects following the same principles of a single incision by using robotic technology. The robotic surgery was initially started as a hybrid procedure with the use of thoracoscopic staplers by the assistant. However, due to the evolution of robotic modern platforms, the staplers can be nowadays controlled by the main surgeon from the console. The pure uniportal robotic-assisted thoracic surgery (U-RATS) is defined as the robotic thoracic surgery performed through a single intercostal (ic) incision, without rib spreading, using the robotic camera, robotic dissecting instruments and robotic staplers. There are presented the advantages, difficulties, the general aspects and specific considerations for U-RATS. For safety reasons, the authors recommend the transition from multiportal-RATS through biportal-RATS to U-RATS. The use of robotic dissection and staplers through a single incision and the rapid undocking with easy emergent conversion when needed (either to U-VATS or to thoracotomy) are safety advantages over multi-port RATS that cannot be overlooked, offering great comfort to the surgeon and quick and smooth recovery to the patient.info:eu-repo/semantics/publishedVersio
Bilateral optic neuritis in a 26-year-old man with common variable immunodeficiency: a case report
<p>Abstract</p> <p>Introduction</p> <p>Common variable immunodeficiency encompasses a group of heterogeneous conditions linked by a lack of immunoglobulin production and primary antibody failure. Although primary immunodeficiencies are typically characterized by recurrent infections, autoimmune manifestations have increasingly been recognized. Neurological complications are extremely rare and to the best of our knowledge optic neuritis has not been described previously. We report the case of a patient with common variable immunodeficiency who developed loss of vision secondary to bilateral optic neuritis.</p> <p>Case presentation</p> <p>A 26-year-old Caucasian man with a diagnosis of common variable immunodeficiency presented to our facility with loss of vision secondary to bilateral optic neuritis. Results of a thorough study for infectious, neoplastic and autoimmune diseases were negative. Our patient was treated with intravenous methylprednisolone with almost complete improvement and he remained asymptomatic at a 12-month follow-up.</p> <p>Conclusions</p> <p>Bilateral optic neuritis should be added to the list of autoimmune disorders related to common variable immunodeficiency. If a patient with common variable immunodeficiency experiences loss of vision, the possibility of bilateral optic neuritis should be considered as rapid initiation of high-dose corticosteroids may improve visual recovery.</p
Star Formation Rate Indicators in Wide-Field Infrared Survey Preliminary Release
With the goal of investigating the degree to which theMIR luminosity in
theWidefield Infrared Survey Explorer (WISE) traces the SFR, we analyze 3.4,
4.6, 12 and 22 {\mu}m data in a sample of {\guillemotright} 140,000
star-forming galaxies or star-forming regions covering a wide range in
metallicity 7.66 < 12 + log(O/H) < 9.46, with redshift z < 0.4. These
star-forming galaxies or star-forming regions are selected by matching the WISE
Preliminary Release Catalog with the star-forming galaxy Catalog in SDSS DR8
provided by JHU/MPA 1.We study the relationship between the luminosity at 3.4,
4.6, 12 and 22 {\mu}m from WISE and H\alpha luminosity in SDSS DR8. From these
comparisons, we derive reference SFR indicators for use in our analysis. Linear
correlations between SFR and the 3.4, 4.6, 12 and 22 {\mu}m luminosity are
found, and calibrations of SFRs based on L(3.4), L(4.6), L(12) and L(22) are
proposed. The calibrations hold for galaxies with verified spectral
observations. The dispersion in the relation between 3.4, 4.6, 12 and 22 {\mu}m
luminosity and SFR relates to the galaxy's properties, such as 4000 {\deg}A
break and galaxy color.Comment: 10 pages, 3 figure
Effectiveness of offloading interventions to heal foot ulcers in persons with diabetes: a systematic review
Background Offloading interventions are commonly used in clinical practice to heal foot ulcers. The aim of this updated systematic review is to investigate the effectiveness of offloading interventions to heal diabetic foot ulcers. Methods We updated our previous systematic review search of PubMed, EMBASE, and Cochrane databases to also include original studies published between July 29, 2014 and August 13, 2018 relating to four offloading intervention categories in populations with diabetic foot ulcers: (a) offloading devices, (b) footwear, (c) other offloading techniques, and (d) surgical offloading techniques. Outcomes included ulcer healing, plantar pressure, ambulatory activity, adherence, adverse events, patientâreported measures, and costâeffectiveness. Included controlled studies were assessed for methodological quality and had key data extracted into evidence and risk of bias tables. Included nonâcontrolled studies were summarised on a narrative basis. Results We identified 41 studies from our updated search for a total of 165 included studies. Six included studies were metaâanalyses, 26 randomised controlled trials (RCTs), 13 other controlled studies, and 120 nonâcontrolled studies. Five metaâanalyses and 12 RCTs provided highâquality evidence for nonâremovable kneeâhigh offloading devices being more effective than removable offloading devices and therapeutic footwear for healing plantar forefoot and midfoot ulcers. Total contact casts (TCCs) and nonâremovable kneeâhigh walkers were shown to be equally effective. Moderateâquality evidence exists for removable kneeâhigh and ankleâhigh offloading devices being equally effective in healing, but kneeâhigh devices have a larger effect on reducing plantar pressure and ambulatory activity. Lowâquality evidence exists for the use of felted foam and surgical offloading to promote healing of plantar forefoot and midfoot ulcers. Very limited evidence exists for the efficacy of any offloading intervention for healing plantar heel ulcers, nonâplantar ulcers, and neuropathic ulcers with infection or ischemia. Conclusion Strong evidence supports the use of nonâremovable kneeâhigh offloading devices (either TCC or nonâremovable walker) as the firstâchoice offloading intervention for healing plantar neuropathic forefoot and midfoot ulcers. Removable offloading devices, either kneeâhigh or ankleâhigh, are preferred as second choice over other offloading interventions. The evidence bases to support any other offloading intervention is still weak and more highâquality controlled studies are needed in these areas
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