305 research outputs found
RG-improved single-particle inclusive cross sections and forward-backward asymmetry in production at hadron colliders
We use techniques from soft-collinear effective theory (SCET) to derive
renormalization-group improved predictions for single-particle inclusive (1PI)
observables in top-quark pair production at hadron colliders. In particular, we
study the top-quark transverse-momentum and rapidity distributions, the
forward-backward asymmetry at the Tevatron, and the total cross section at
NLO+NNLL order in resummed perturbation theory and at approximate NNLO in fixed
order. We also perform a detailed analysis of power corrections to the leading
terms in the threshold expansion of the partonic hard-scattering kernels. We
conclude that, although the threshold expansion in 1PI kinematics is
susceptible to numerically significant power corrections, its predictions for
the total cross section are in good agreement with those obtained by
integrating the top-pair invariant-mass distribution in pair invariant-mass
kinematics, as long as a certain set of subleading terms appearing naturally
within the SCET formalism is included.Comment: 55 pages, 14 figures, 6 table
Flavor conversion of cosmic neutrinos from hidden jets
High energy cosmic neutrino fluxes can be produced inside relativistic jets
under the envelopes of collapsing stars. In the energy range E ~ (0.3 - 1e5)
GeV, flavor conversion of these neutrinos is modified by various matter effects
inside the star and the Earth. We present a comprehensive (both analytic and
numerical) description of the flavor conversion of these neutrinos which
includes: (i) oscillations inside jets, (ii) flavor-to-mass state transitions
in an envelope, (iii) loss of coherence on the way to observer, and (iv)
oscillations of the mass states inside the Earth. We show that conversion has
several new features which are not realized in other objects, in particular
interference effects ("L- and H- wiggles") induced by the adiabaticity
violation. The neutrino-neutrino scattering inside jet and inelastic neutrino
interactions in the envelope may produce some additional features at E > 1e4
GeV. We study dependence of the probabilities and flavor ratios in the
matter-affected region on angles theta13 and theta23, on the CP-phase delta, as
well as on the initial flavor content and density profile of the star. We show
that measurements of the energy dependence of the flavor ratios will, in
principle, allow to determine independently the neutrino and astrophysical
parameters.Comment: 56 pages, 19 figures. Minor changes. Accepted by JHEP
NLO QCD corrections to off-shell top-antitop production with leptonic decays at hadron colliders
We present details of a calculation of the cross section for hadronic
top-antitop production in next-to-leading order (NLO) QCD, including the decays
of the top and antitop into bottom quarks and leptons. This calculation is
based on matrix elements for \nu e e+ \mu- \bar{\nu}_{\mu}b\bar{b} production
and includes all non-resonant diagrams, interferences, and off-shell effects of
the top quarks. Such contributions are formally suppressed by the top-quark
width and turn out to be small in the inclusive cross section. However, they
can be strongly enhanced in exclusive observables that play an important role
in Higgs and new-physics searches. Also non-resonant and off-shell effects due
to the finite W-boson width are investigated in detail, but their impact is
much smaller than naively expected. We also introduce a matching approach to
improve NLO calculations involving intermediate unstable particles. Using a
fixed QCD scale leads to perturbative instabilities in the high-energy tails of
distributions, but an appropriate dynamical scale stabilises NLO predictions.
Numerical results for the total cross section, several distributions, and
asymmetries are presented for Tevatron and the LHC at 7 TeV, 8 TeV, and 14 TeV.Comment: 61 pp. Matches version published in JHEP; one more reference adde
Predictions for Higgs production at the Tevatron and the associated uncertainties
We update the theoretical predictions for the production cross sections of
the Standard Model Higgs boson at the Fermilab Tevatron collider, focusing on
the two main search channels, the gluon-gluon fusion mechanism and
the Higgs-strahlung processes with , including all
relevant higher order QCD and electroweak corrections in perturbation theory.
We then estimate the various uncertainties affecting these predictions: the
scale uncertainties which are viewed as a measure of the unknown higher order
effects, the uncertainties from the parton distribution functions and the
related errors on the strong coupling constant, as well as the uncertainties
due to the use of an effective theory approach in the determination of the
radiative corrections in the process at next-to-next-to-leading
order. We find that while the cross sections are well under control in the
Higgs--strahlung processes, the theoretical uncertainties are rather large in
the case of the gluon-gluon fusion channel, possibly shifting the central
values of the next-to-next-to-leading order cross sections by more than
. These uncertainties are thus significantly larger than the
error assumed by the CDF and D0 experiments in their recent
analysis that has excluded the Higgs mass range 162-166 GeV at the 95%
confidence level. These exclusion limits should be, therefore, reconsidered in
the light of these large theoretical uncertainties.Comment: 40 pages, 12 figures. A few typos are corrected and some updated
numbers are provide
Adult Male Mice Emit Context-Specific Ultrasonic Vocalizations That Are Modulated by Prior Isolation or Group Rearing Environment
Social interactions in mice are frequently analysed in genetically modified strains in order to get insight of disorders affecting social interactions such as autism spectrum disorders. Different types of social interactions have been described, mostly between females and pups, and between adult males and females. However, we recently showed that social interactions between adult males could also encompass cognitive and motivational features. During social interactions, rodents emit ultrasonic vocalizations (USVs), but it remains unknown if call types are differently used depending of the context and if they are correlated with motivational state. Here, we recorded the calls of adult C57BL/6J male mice in various behavioral conditions, such as social interaction, novelty exploration and restraint stress. We introduced a modulator for the motivational state by comparing males maintained in isolation and males maintained in groups before the experiments. Male mice uttered USVs in all social and non-social situations, and even in a stressful restraint context. They nevertheless emitted the most important number of calls with the largest diversity of call types in social interactions, particularly when showing a high motivation for social contact. For mice maintained in social isolation, the number of calls recorded was positively correlated with the duration of social contacts, and most calls were uttered during contacts between the two mice. This correlation was not observed in mice maintained in groups. These results open the way for a deeper understanding and characterization of acoustic signals associated with social interactions. They can also help evaluating the role of motivational states in the emission of acoustic signals
Missed treatment opportunities and barriers to comprehensive treatment for sexual violence survivors in Kenya: a mixed methods study
Background
In Kenya, most sexual violence survivors either do not access healthcare, access healthcare late or do not complete treatment. To design interventions that ensure optimal healthcare for survivors, it is important to understand the characteristics of those who do and do not access healthcare. In this paper, we aim to: compare the characteristics of survivors who present for healthcare to those of survivors reporting violence on national surveys; understand the healthcare services provided to survivors; and, identify barriers to treatment.
Methods
A mixed methods approach was used. Hospital records for survivors from two referral hospitals were compared with national-level data from the Kenya Demographic and Health Survey 2014, and the Violence Against Children Survey 2010. Descriptive summaries were calculated and differences in characteristics of the survivors assessed using chi-square tests. Qualitative data from six in-depth interviews with healthcare providers were analysed thematically.
Results
Among the 543 hospital respondents, 93.2% were female; 69.5% single; 71.9% knew the perpetrator; and 69.2% were children below 18 years. Compared to respondents disclosing sexual violence in nationally representative datasets, those who presented at hospital were less likely to be partnered, male, or assaulted by an intimate partner. Data suggest missed opportunities for treatment among those who did present to hospital: HIV PEP and other STI prophylaxis was not given to 30 and 16% of survivors respectively; 43% of eligible women did not receive emergency contraceptive; and, laboratory results were missing in more than 40% of the records. Those aged 18 years or below and those assaulted by known perpetrators were more likely to miss being put on HIV PEP. Qualitative data highlighted challenges in accessing and providing healthcare that included stigma, lack of staff training, missing equipment and poor coordination of services.
Conclusions
Nationally, survivors at higher risk of not accessing healthcare include older survivors; partnered or ever partnered survivors; survivors experiencing sexual violence from intimate partners; children experiencing violence in schools; and men. Interventions at the community level should target survivors who are unlikely to access healthcare and address barriers to early access to care. Staff training and specific clinical guidelines/protocols for treating children are urgently needed
A Generalized Linear Model for Estimating Spectrotemporal Receptive Fields from Responses to Natural Sounds
In the auditory system, the stimulus-response properties of single neurons are often described in terms of the spectrotemporal receptive field (STRF), a linear kernel relating the spectrogram of the sound stimulus to the instantaneous firing rate of the neuron. Several algorithms have been used to estimate STRFs from responses to natural stimuli; these algorithms differ in their functional models, cost functions, and regularization methods. Here, we characterize the stimulus-response function of auditory neurons using a generalized linear model (GLM). In this model, each cell's input is described by: 1) a stimulus filter (STRF); and 2) a post-spike filter, which captures dependencies on the neuron's spiking history. The output of the model is given by a series of spike trains rather than instantaneous firing rate, allowing the prediction of spike train responses to novel stimuli. We fit the model by maximum penalized likelihood to the spiking activity of zebra finch auditory midbrain neurons in response to conspecific vocalizations (songs) and modulation limited (ml) noise. We compare this model to normalized reverse correlation (NRC), the traditional method for STRF estimation, in terms of predictive power and the basic tuning properties of the estimated STRFs. We find that a GLM with a sparse prior predicts novel responses to both stimulus classes significantly better than NRC. Importantly, we find that STRFs from the two models derived from the same responses can differ substantially and that GLM STRFs are more consistent between stimulus classes than NRC STRFs. These results suggest that a GLM with a sparse prior provides a more accurate characterization of spectrotemporal tuning than does the NRC method when responses to complex sounds are studied in these neurons
Constraints on the gluon PDF from top quark pair production at hadron colliders
Using the recently derived NNLO cross sections \cite{Czakon:2013goa}, we
provide NNLO+NNLL theoretical predictions for top quark pair production based
on all the available NNLO PDF sets, and compare them with the most precise LHC
and Tevatron data. In this comparison we study in detail the PDF uncertainty
and the scale, and dependence of the theoretical predictions
for each PDF set. Next, we observe that top quark pair production provides a
powerful direct constraint on the gluon PDF at large , and include Tevatron
and LHC top pair data consistently into a global NNLO PDF fit. We then explore
the phenomenological consequences of the reduced gluon PDF uncertainties, by
showing how they can improve predictions for Beyond the Standard Model
processes at the LHC. Finally, we update to full NNLO+NNLL the theoretical
predictions for the ratio of top quark cross sections between different LHC
center of mass energies, as well as the cross sections for hypothetical heavy
fourth-generation quark production at the LHC.Comment: 29 pages, 13 figures, accepted for publication in JHE
Elevated Stress-Hemoconcentration in Major Depression Is Normalized by Antidepressant Treatment: Secondary Analysis from a Randomized, Double-Blind Clinical Trial and Relevance to Cardiovascular Disease Risk
Major depressive disorder (MDD) is an independent risk factor for cardiovascular disease (CVD); the presence of MDD symptoms in patients with CVD is associated with a higher incidence of cardiac complications following acute myocardial infarction (MI). Stress-hemoconcentration, a result of psychological stress that might be a risk factor for the pathogenesis of CVD, has been studied in stress-challenge paradigms but has not been systematically studied in MDD.Secondary analysis of stress hemoconcentration was performed on data from controls and subjects with mild to moderate MDD participating in an ongoing pharmacogenetic study of antidepressant treatment response to desipramine or fluoxetine. Hematologic and hemorheologic measures of stress-hemoconcentration included blood cell counts, hematocrit, hemoglobin, total serum protein, and albumin, and whole blood viscosity.Subjects with mild to moderate MDD had significantly increased hemorheologic measures of stress-hemoconcentration and blood viscosity when compared to controls; these measures were correlated with depression severity. Measures of stress-hemoconcentration improved significantly after 8 weeks of antidepressant treatment. Improvements in white blood cell count, red blood cell measures and plasma volume were correlated with decreased severity of depression.Our secondary data analyses support that stress-hemoconcentration, possibly caused by decrements in plasma volume during psychological stress, is present in Mexican-American subjects with mild to moderate MDD at non-challenged baseline conditions. We also found that after antidepressant treatment hemorheologic measures of stress-hemoconcentration are improved and are correlated with improvement of depressive symptoms. These findings suggest that antidepressant treatment may have a positive impact in CVD by ameliorating increased blood viscosity. Physicians should be aware of the potential impact of measures of hemoconcentration and consider the implications for cardiovascular risk in depressed patients
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