Preliminary Studies of Magnetic NDE Techniques for Identifying Neutron Embrittlement of Pressure Vessel Steel

In operating nuclear reactors, the steel pressure vessel is exposed to neutron irradiation. The high energy part (\u3e1 MeV) of this irradiation, over a long period, makes the steel brittle and susceptible to rupture

Supersymmetry enhancement by monopole operators

We describe a method which allows one to study hidden symmetries in a large class of strongly coupled supersymmetric gauge theories in three dimensions. We apply this method to the ABJM theory and to the infrared limit of N=4 SQCD with adjoint and fundamental matter. We show that the U(N) ABJM model with Chern-Simons level k=1 or k=2 has hidden N=8 supersymmetry. Hidden supersymmetry is also shown to occur in N=4 d=3 SQCD with one fundamental and one adjoint hypermultiplet. The latter theory, as well as the U(N) ABJM theory at k=1, are shown to have a decoupled free sector. This provides evidence that both models are dual to the infrared limit of N=8 U(N) super-Yang-Mills theory.Comment: 29 pages, late

New and old N=8 superconformal field theories in three dimensions

We show that an infinite family of N=6 d=3 superconformal Chern-Simons-matter theories has hidden N=8 superconformal symmetry and hidden parity on the quantum level. This family of theories is different from the one found by Aharony, Bergman, Jafferis and Maldacena, as well as from the theories constructed by Bagger and Lambert, and Gustavsson. We also test several conjectural dualities between BLG theories and ABJ theories by comparing superconformal indices of these theories.Comment: 16 pages, late

Duality between N=5 and N=6 Chern-Simons matter theory

We provide evidences for the duality between ${\cal N}=6$ $U(M)_{4} \times U(N)_{-4}$ Chern-Simons matter theory and ${\cal N}=5$ $O(\hat{M})_{2} \times USp(2\hat{N})_{-1}$ theory for a suitable $\hat{M},\hat{N}$ by working out the superconformal index, which shows perfect matching. For ${\cal N}=5$ theories, we show that supersymmetry is enhanced to ${\cal N}=6$ by explicitly constructing monopole operators filling in $SO(6)_R$ $R$-currents. Finally we work out the large $N$ index of $O(2N)_{2k} \times USp(2N)_{-k}$ and show that it exactly matches with the gravity index on $AdS_4 \times S^7/D_k$, which further provides additional evidence for the duality between the ${\cal N}=5$ and ${\cal N}=6$ theory for $k=1$Comment: 15 pages; references adde

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia.

In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of initiating lesions, and order of subsequent mutations remain poorly understood, as AML is typically diagnosed without observation of a pre-leukaemic phase. Here, highly purified haematopoietic stem cells (HSCs), progenitor and mature cell fractions from the blood of AML patients were found to contain recurrent DNMT3A mutations (DNMT3A(mut)) at high allele frequency, but without coincident NPM1 mutations (NPM1c) present in AML blasts. DNMT3A(mut)-bearing HSCs showed a multilineage repopulation advantage over non-mutated HSCs in xenografts, establishing their identity as pre-leukaemic HSCs. Pre-leukaemic HSCs were found in remission samples, indicating that they survive chemotherapy. Therefore DNMT3A(mut) arises early in AML evolution, probably in HSCs, leading to a clonally expanded pool of pre-leukaemic HSCs from which AML evolves. Our findings provide a paradigm for the detection and treatment of pre-leukaemic clones before the acquisition of additional genetic lesions engenders greater therapeutic resistance

Enhanced Supersymmetry of Nonrelativistic ABJM Theory

We study the supersymmetry enhancement of nonrelativistic limits of the ABJM theory for Chern-Simons level $k=1,2$. The special attention is paid to the nonrelativistic limit (known as `PAAP' case) containing both particles and antiparticles. Using supersymmetry transformations generated by the monopole operators, we find additional 2 kinematical, 2 dynamical, and 2 conformal supercharges for this case. Combining with the original 8 kinematical supercharges, the total number of supercharges becomes maximal: 14 supercharges, like in the well-known PPPP limit. We obtain the corresponding super Schr\"odinger algebra which appears to be isomorphic to the one of the PPPP case. We also discuss the role of monopole operators in supersymmetry enhancement and partial breaking of supersymmetry in nonrelativistic limit of the ABJM theory.Comment: 22 pages, references added, version to appear in JHE

Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53

Background: The availability of various "omics" datasets creates a prospect of performing the study of genome-wide genetic regulatory networks. However, one of the major challenges of using mathematical models to infer genetic regulation from microarray datasets is the lack of information for protein concentrations and activities. Most of the previous researches were based on an assumption that the mRNA levels of a gene are consistent with its protein activities, though it is not always the case. Therefore, a more sophisticated modelling framework together with the corresponding inference methods is needed to accurately estimate genetic regulation from "omics" datasets. Results: This work developed a novel approach, which is based on a nonlinear mathematical model, to infer genetic regulation from microarray gene expression data. By using the p53 network as a test system, we used the nonlinear model to estimate the activities of transcription factor (TF) p53 from the expression levels of its target genes, and to identify the activation/inhibition status of p53 to its target genes. The predicted top 317 putative p53 target genes were supported by DNA sequence analysis. A comparison between our prediction and the other published predictions of p53 targets suggests that most of putative p53 targets may share a common depleted or enriched sequence signal on their upstream non-coding region. Conclusions: The proposed quantitative model can not only be used to infer the regulatory relationship between TF and its down-stream genes, but also be applied to estimate the protein activities of TF from the expression levels of its target genes

Aspects of ABJM orbifolds with discrete torsion

We analyze orbifolds with discrete torsion of the ABJM theory by a finite subgroup $\Gamma$ of $SU(2)\times SU(2)$ . Discrete torsion is implemented by twisting the crossed product algebra resulting after orbifolding. It is shown that, in general, the order $m$ of the cocycle we chose to twist the algebra by enters in a non trivial way in the moduli space. To be precise, the M-theory fiber is multiplied by a factor of $m$ in addition to the other effects that were found before in the literature. Therefore we got a $\mathbb{Z}_{\frac{k|\Gamma|}{m}}$ action on the fiber. We present a general analysis on how this quotient arises along with a detailed analysis of the cases where $\Gamma$ is abelian

Advances in small lasers

M.T.H was supported by an Australian Research council Future Fellowship research grant for this work. M.C.G. is grateful to the Scottish Funding Council (via SUPA) for financial support.Small lasers have dimensions or modes sizes close to or smaller than the wavelength of emitted light. In recent years there has been significant progress towards reducing the size and improving the characteristics of these devices. This work has been led primarily by the innovative use of new materials and cavity designs. This Review summarizes some of the latest developments, particularly in metallic and plasmonic lasers, improvements in small dielectric lasers, and the emerging area of small bio-compatible or bio-derived lasers. We examine the different approaches employed to reduce size and how they result in significant differences in the final device, particularly between metal- and dielectric-cavity lasers. We also present potential applications for the various forms of small lasers, and indicate where further developments are required.PostprintPeer reviewe

On thermodynamics of N=6 superconformal Chern-Simons theory

We study thermodynamics of N=6 superconformal Chern-Simons theory by computing quantum corrections to the free energy. We find that in weakly coupled ABJM theory on R(2) x S(1), the leading correction is non-analytic in the 't Hooft coupling lambda, and is approximately of order lambda^2 log(lambda)^3. The free energy is expressed in terms of the scalar thermal mass m, which is generated by screening effects. We show that this mass vanishes to 1-loop order. We then go on to 2-loop order where we find a finite and positive mass squared m^2. We discuss differences in the calculation between Coulomb and Lorentz gauge. Our results indicate that the free energy is a monotonic function in lambda which interpolates smoothly to the N^(3/2) behaviour at strong coupling.Comment: 29 pages. v2: references added. v3: minor changes, references added, published versio