2,137 research outputs found
The intestinal virome in children with cystic fibrosis differs from healthy controls.
Intestinal bacterial dysbiosis is evident in children with cystic fibrosis (CF) and intestinal viruses may be contributory, given their influence on bacterial species diversity and biochemical cycles. We performed a prospective, case-control study on children with CF and age and gender matched healthy controls (HC), to investigate the composition and function of intestinal viral communities. Stool samples were enriched for viral DNA and RNA by viral extraction, random amplification and purification before sequencing (Illumina MiSeq). Taxonomic assignment of viruses was performed using Vipie. Functional annotation was performed using Virsorter. Inflammation was measured by calprotectin and M2-pyruvate kinase (M2-PK). Eight CF and eight HC subjects were included (50% male, mean age 6.9 ± 3.0 and 6.4 ± 5.3 years, respectively, p = 0.8). All CF subjects were pancreatic insufficient. Regarding the intestinal virome, no difference in Shannon index between CF and HC was identified. Taxonomy-based beta-diversity (presence-absence Bray-Curtis dissimilarity) was significantly different between CF and HC (R2 = 0.12, p = 0.001). Myoviridae, Faecalibacterium phage FP Taranis and unclassified Gokushovirinae were significantly decreased in CF compared with HC (q<0.05). In children with CF (compared to HC), the relative abundance of genes annotated to (i) a peptidoglycan-binding domain of the peptidoglycan hydrolases (COG3409) was significantly increased (q<0.05) and (ii) capsid protein (F protein) (PF02305.16) was significantly decreased (q<0.05). Picornavirales, Picornaviridae, and Enterovirus were found to positively correlate with weight and BMI (r = 0.84, q = 0.01). Single-stranded DNA viruses negatively correlated with M2-PK (r = -0.86, q = 0.048). Children with CF have an altered intestinal virome compared to well-matched HC, with both taxonomic and predicted functional changes. Further exploration of Faecalibacterium phages, Gokushovirinae and phage lysins are warranted. Intestinal viruses and their functions may have important clinical implications for intestinal inflammation and growth in children with CF, potentially providing novel therapeutic targets
Somatostatin triggers rhythmic electrical firing in hypothalamic GHRH neurons
International audienc
Effective String Theory Revisited
We revisit the effective field theory of long relativistic strings such as
confining flux tubes in QCD. We derive the Polchinski-Strominger interaction by
a calculation in static gauge. This interaction implies that a non-critical
string which initially oscillates in one direction gets excited in orthogonal
directions as well. In static gauge no additional term in the effective action
is needed to obtain this effect. It results from a one-loop calculation using
the Nambu-Goto action. Non-linearly realized Lorentz symmetry is manifest at
all stages in dimensional regularization. We also explain that independent of
the number of dimensions non-covariant counterterms have to be added to the
action in the commonly used zeta-function regularization.Comment: 21 pages, 4 figures, v2: typo corrected, references added, published
versio
Collective Quartics from Simple Groups
This article classifies Little Higgs models that have collective quartic
couplings. There are two classes of collective quartics: Special Cosets and
Special Quartics. After taking into account dangerous singlets, the smallest
Special Coset models are SU(5)/SO(5) and SU(6)/Sp(6). The smallest Special
Quartic model is SU(5)/SU(3) x SU(2) x U(1) and has not previously been
considered as a candidate Little Higgs model.Comment: 22 pages, 2 figure
Model-Independent Bounds on a Light Higgs
We present up-to-date constraints on a generic Higgs parameter space. An
accurate assessment of these exclusions must take into account statistical, and
potentially signal, fluctuations in the data currently taken at the LHC. For
this, we have constructed a straightforward statistical method for making full
use of the data that is publicly available. We show that, using the expected
and observed exclusions which are quoted for each search channel, we can fully
reconstruct likelihood profiles under very reasonable and simple assumptions.
Even working with this somewhat limited information, we show that our method is
sufficiently accurate to warrant its study and advocate its use over more naive
prescriptions. Using this method, we can begin to narrow in on the remaining
viable parameter space for a Higgs-like scalar state, and to ascertain the
nature of any hints of new physics---Higgs or otherwise---appearing in the
data.Comment: 32 pages, 10 figures; v3: correction made to basis of four-derivative
operators in the effective Lagrangian, references adde
UV friendly T-parity in the SU(6)/Sp(6) little Higgs model
Electroweak precision tests put stringent constraints on the parameter space
of little Higgs models. Tree-level exchange of TeV scale particles in a generic
little Higgs model produce higher dimensional operators that make contributions
to electroweak observables that are typically too large. To avoid this problem
a discrete symmetry dubbed T-parity can be introduced to forbid the dangerous
couplings. However, it was realized that in simple group models such as the
littlest Higgs model, the implementation of T-parity in a UV completion could
present some challenges. The situation is analogous to the one in QCD where the
pion can easily be defined as being odd under a new symmetry in the
chiral Lagrangian, but this is not a symmetry of the quark Lagrangian. In
this paper we examine the possibility of implementing a T-parity in the low
energy model that might be easier to realize in the UV. In our
model, the T-parity acts on the low energy non-linear sigma model field in way
which is different to what was originally proposed for the Littlest Higgs, and
lead to a different low energy theory. In particular, the Higgs sector of this
model is a inert two Higgs doublets model with an approximate custodial
symmetry. We examine the contributions of the various sectors of the model to
electroweak precision data, and to the dark matter abundance.Comment: 21 pages,4 figures. Clarifications added, typos corrected and
references added. Published in JHE
Constitutive TLR4 signalling in intestinal epithelium reduces tumor load by increasing apoptosis in APC(Min/+) mice
Singapore Immunology Network (SIgN)—SIgN 10-038
Improving the sensitivity of Higgs boson searches in the golden channel
Leptonic decays of the Higgs boson in the ZZ* channel yield what is known as
the golden channel due to its clean signature and good total invariant mass
resolution. In addition, the full kinematic distribution of the decay products
can be reconstructed, which, nonetheless, is not taken into account in
traditional search strategy relying only on measurements of the total invariant
mass. In this work we implement a type of multivariate analysis known as the
matrix element method, which exploits differences in the full production and
decay matrix elements between the Higgs boson and the dominant irreducible
background from q bar{q} -> ZZ*. Analytic expressions of the differential
distributions for both the signal and the background are also presented. We
perform a study for the Large Hadron Collider at sqrt{s}=7 TeV for Higgs masses
between 175 and 350 GeV. We find that, with an integrated luminosity of 2.5
fb^-1 or higher, improvements in the order of 10 - 20 % could be obtained for
both discovery significance and exclusion limits in the high mass region, where
the differences in the angular correlations between signal and background are
most pronounced.Comment: 31 pages, 8 figures. v2: Minus signs in definitions of angles
corrected. Typos fixed. Reference added. Cosmetic changes to Figure 4.
Additional sentence added for clarificatio
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Coronal mass ejections are not coherent magnetohydrodynamic structures
Coronal mass ejections (CMEs) are episodic eruptions of solar plasma and magnetic flux that travel out through the solar system, driving extreme space weather. Interpretation of CME observations and their interaction with the solar wind typically assumes CMEs are coherent, almost solid-like objects. We show that supersonic radial propagation of CMEs away from the Sun results in geometric expansion of CME plasma parcels at a speed faster than the local wave speed. Thus information cannot propagate across the CME. Comparing our results with observed properties of over 400 CMEs, we show that CMEs cease to be coherent magnetohydrodynamic structures within 0.3 AU of the Sun. This suggests Earth-directed CMEs are less like billiard balls and more like dust clouds, with apparent coherence only due to similar initial conditions and quasi homogeneity of the medium through which they travel. The incoherence of CMEs suggests interpretation of CME observations requires accurate reconstruction of the ambient solar wind with which they interact, and that simple assumptions about the shape of the CMEs are likely to be invalid when significant spatial/temporal gradients in ambient solar wind conditions are present
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