Functional differentiation of chloride metabolism in euryhaline tilapia,Oreochromis mossambicus

報告番号: 甲14815 ; 学位授与年月日: 1999-12-13 ; 学位の種別: 課程博士 ; 学位の種類: 博士(理学) ; 学位記番号: 博理第3672号 ; 研究科・専攻: 理学系研究科生物科学専

Performance and Internal Flow of Contra-Rotating Small-Sized Cooling Fan

International audienceHigh pressure and large flow rate small-sized cooling fans are used for servers in data centers and there is a strong demand to increase its performance because of increase of quantity of heat from servers. Therefore, high rotational speed design is conducted, and rotational speed over 10,000min-1 is employed for cooling fans of servers. Contra-rotating rotors have been adopted for some of high pressure and large flow rate cooling fans to meet the demand. The company's research and development period for the contra-rotating small-sized cooling fan is short and its internal flow condition is not clarified well. Therefore, the internal flow condition was investigated by the numerical analysis. In the present paper, fan static pressure curves of the contra-rotating small-sized cooling fan with a 40mm square casing are shown by the experimental. Furthermore, the influences of the geometrical shape and design specification of the contra-rotating small-sized cooling fan on the internal flow condition are clarified by the numerical analysis

Content-based CT image retrieval system using deep learning: Preliminary assessment of its accuracy for classifying lesion patterns and retrieving similar cases among patients with diffuse lung diseases

Practical image retrieval systems must fully use image databases. We investigated the accuracy of our content-based computer tomography (CT) image retrieval system (CB-CTIRS) for classifying lesion patterns and retrieving similar cases in patients with diffuse lung diseases. The study included 503 individuals, with 328 having diffuse lung disease and 175 having normal chest CT scans. Among the former, we randomly selected ten scans that revealed one of five specific patterns [consolidation, ground-glass opacity (GGO), emphysema, honeycombing, or micronodules: two cases each]. Two radiologists separated the squares into six categories (five abnormal patterns and one normal pattern) to create a reference standard. Subsequently, each square was entered into the CB-CTIRS, and the F-score used to classify squares was determined. Next, we selected 15 cases (three per pattern) among the 503 cases, which served as the query cases. Three other radiologists graded the similarity between the retrieved and query cases using a 5-point grading system, where grade 5 = similar in both the opacity pattern and distribution and 1 = different therein. The F-score was 0.71 for consolidation, 0.63 for GGO, 0.74 for emphysema, 0.61 for honeycombing, 0.15 for micronodules, and 0.67 for normal lung. All three radiologists assigned grade 4 or 5 to 67.7% of retrieved cases with consolidation, emphysema, or honeycombing, and grade 2 or 3 to 67.7% of the retrieved cases with GGO or micronodules. The retrieval accuracy of CB-CTIRS is satisfactory for consolidation, emphysema, and honeycombing but not for GGO or micronodules

Protective effects of metallothionein against dopamine quinone-induced dopaminergic neurotoxicity

AbstractDopamine (DA) quinone as DA neuron-specific oxidative stress conjugates with cysteine residues in functional proteins to form quinoproteins. Here, we examined the effects of cysteine-rich metal-binding proteins, metallothionein (MT)-1 and -2, on DA quinone-induced neurotoxicity. MT quenched DA semiquinones in vitro. In dopaminergic cells, DA exposure increased quinoproteins and decreased cell viability; these were ameliorated by pretreatment with MT-inducer zinc. Repeated L-DOPA administration markedly elevated striatal quinoprotein levels and reduced the DA nerve terminals specifically on the lesioned side in MT-knockout parkinsonian mice, but not in wild-type mice. Our results suggested that intrinsic MT protects against L-DOPA-induced DA quinone neurotoxicity in parkinsonian mice by its quinone-quenching property