1,063 research outputs found
Relação entre a inteligência emocional e os traços de personalidade segundo o Modelo dos Cinco Fatores em estudantes do ensino superior
A inteligência emocional é vista como um tipo de inteligência relacionada com o
processamento cognitivo das emoções e assenta na capacidade de compreender
corretamente as emoções e geri-las de uma maneira adaptativa e adequada. Vários
autores associam a IE a varias características pessoais (felicidade, autoestima, otimismo
e capacidades). Teoricamente há um destaque para os modelos dos traços da
personalidade, identificando a IE como um traço. Deste modo criaram-se instrumentos
fundamentais para mediar a IE quando esta é vista como um traço.
O Modelo dos Cinco Fatores é o mais importante e usado para compreender a
personalidade do ser humano. O modelo apresenta cinco traços de personalidade:
Extroversão, Amabilidade, Conscienciosidade, Neuroticismo e Abertura para
Experiência. Este estudo teve como objetivos principais caracterizar a inteligência
emocional e os traços de personalidade, segundo o Modelo dos Cinco Fatores, nos
estudantes do ensino superior; explorar a relação entre estas variáveis com as variáveis
sociodemográficas e explorar a relação entre a inteligência emocional e os traços de
personalidade segundo o Modelo dos Cinco Fatores. A amostra foi composta por 177
participantes, 83.6% do sexo feminino e 15.8% do sexo masculino, com idades
compreendidas entre os 18 e os 57 anos de idade, a frequentar os cursos de Psicologia,
Ciências da Comunicação, Serviço Social e Tecnologias de Informação e Comunicação.
A inteligência emocional foi avaliada através do Neo-Five Factory Inventory e os traços
de personalidade foram avaliados através da Escala de Inteligência Emocional de
Schutte. Nos resultados registaram-se maiores pontuações nas subescalas da Perceção
das emoções e Lidar com as emoções dos outros (M=36.97). Verificaram-se diferenças
estatisticamente significativas positivas entre algumas subescalas e dimensões em
relação ao sexo e ao curso. Em relação ao sexo verificou-se que o sexo feminino obtém
maiores pontuações na maioria das subescalas e os estudantes que frequentam os cursos
de Serviço Social e Psicologia possuem um maior nível de inteligência emocional
comparado com os estudantes dos restantes cursos.Emotional intelligence is seen as a type of intelligence related to the cognitive processing
of emotions and is based on the ability to correctly understand emotions and manage them
in an adaptive and appropriate way. Several authors associate EI with various personal
characteristics (happiness, self-esteem, optimism and abilities). Theoretically, there is an
emphasis on personality trait models, identifying EI as a trait. In this way, fundamental
instruments were created to mediate EI when it is seen as a trait.
The Five Factors Model is the most important and used to understand human personality.
The model features five personality traits: Extroversion, Amiability, Conscientiousness,
Neuroticism and Openness to Experience. This study had as main objectives to
characterize emotional intelligence and personality traits, according to the Five Factors
Model, in higher education students; explore the relationship between these variables with
sociodemographic variables and explore the relationship between emotional intelligence
and personality traits according to the Five Factors Model. The sample consisted of 177
participants, 83.6% female and 15.8% male, aged between 18 and 57 years old, attending
Psychology, Communication Sciences, Social Work and Information Technology courses
and Communication. Emotional intelligence was assessed using the Neo-Five Factory
Inventory and personality traits were assessed using the Schutte Emotional Intelligence
Scale. In the results, there were higher scores in the subscales of Perception of emotions
and Dealing with the emotions of others (M=36.97). There were statistically significant
positive differences between some subscales and dimensions in relation to gender and
course. Regarding gender, it was found that females obtain higher scores in most
subscales and students who attend courses in Social Work and Psychology have a higher
level of emotional intelligence compared to students in other courses
The Non-Canonical Wnt/PKC Pathway Regulates Mitochondrial Dynamics through Degradation of the Arm-Like Domain-Containing Protein Alex3
The regulation of mitochondrial dynamics is vital in complex cell types, such as neurons, that transport and localize mitochondria in high energy-demanding cell domains. The Armcx3 gene encodes a mitochondrial-targeted protein (Alex3) that contains several arm-like domains. In a previous study we showed that Alex3 protein regulates mitochondrial aggregation and trafficking. Here we studied the contribution of Wnt proteins to the mitochondrial aggregation and dynamics regulated by Alex3. Overexpression of Alex3 in HEK293 cells caused a marked aggregation of mitochondria, which was attenuated by treatment with several Wnts. We also found that this decrease was caused by Alex3 degradation induced by Wnts. While the Wnt canonical pathway did not alter the pattern of mitochondrial aggregation induced by Alex3, we observed that the Wnt/PKC non-canonical pathway regulated both mitochondrial aggregation and Alex3 protein levels, thereby rendering a mitochondrial phenotype and distribution similar to control patterns. Our data suggest that the Wnt pathway regulates mitochondrial distribution and dynamics through Alex3 protein degradation
The hidden fragility in the heart of the athletes: A review of genetic biomarkers
Sudden cardiac death (SCD) is a devastating event which can also affect people in apparent good health, such as young athletes. It is known that intense and continuous exercise along with a genetic background that predisposes a person to the risk of fatal arrhythmias is a trigger for SCD. Therefore, knowledge of the athlete’s genetic conditions underlying the onset of SCD must be extended, in order to develop new effective prevention and/or therapeutic strategies. Arrhythmic features occur across a broad spectrum of cardiac diseases, sometimes presenting with overlapping phenotypes. The genetic basis of arrhythmogenic disorders has been greatly highlighted in the last 30 years, and has shown marked heterogeneity. The advent of next-generation sequencing has constantly updated our understanding of the genetic basis of arrhythmogenic diseases and is laying the foundation for precision medicine. With the exception of a few clinical cases involving a single athlete showing a highly suspected phenotype for the presence of a heart disease, there are few studies to date that analysed the applicability of genetic testing on cohorts of athletes. This evidence shows that genetic testing can contribute to the diagnosis of up to 13% of athletes; however, the presence of clinical markers is essential. This review aims to provide a reference collection on current knowledge of the genetic basis of sudden cardiac death in athletes and to review updated evidence on the effectiveness of genetic testing in early identification of athletes at risk for SCD
Beam test, simulation, and performance evaluation of PbF and PWO-UF crystals with SiPM readout for a semi-homogeneous calorimeter prototype with longitudinal segmentation
Crilin (Crystal Calorimeter with Longitudinal Information) is a
semi-homogeneous, longitudinally segmented electromagnetic calorimeter based on
high-, ultra-fast crystals with UV-extended SiPM readout. The Crilin design
has been proposed as a candidate solution for both a future Muon Collider
barrel ECAL and for the Small Angle Calorimeter of the HIKE experiment. As a
part of the Crilin development program, we have carried out beam tests of small
(~mm) lead fluoride (PbF) and ultra-fast lead
tungstate (PbWO, PWO) crystals with 120~GeV electrons at the CERN SPS to
study the light yield, timing response, and systematics of light collection
with a proposed readout scheme. For a single crystal of PbF, corresponding
to a single Crilin cell, a time resolution of better than 25~ps is obtained for
3 GeV of deposited energy. For a single cell of \pwo, a time resolution of
better than 45~ps is obtained for the same range of deposited energy. This
timing performance fully satisfies the design requirements for the Muon
Collider and HIKE experiments. Further optimizations of the readout scheme and
crystal surface preparation are expected to bring further improvements
The Pervasive Effects of ER Stress on a Typical Endocrine Cell: Dedifferentiation, Mesenchymal Shift and Antioxidant Response in the Thyrocyte
none13noThe endoplasmic reticulum stress and the unfolded protein response are triggered following an imbalance between protein load and protein folding. Until recently, two possible outcomes of the unfolded protein response have been considered: life or death. We sought to substantiate a third alternative, dedifferentiation, mesenchymal shift, and activation of the antioxidant response by using typical endocrine cells, i.e. thyroid cells. The thyroid is a unique system both of endoplasmic reticulum stress (a single protein, thyroglobulin represents the majority of proteins synthesized in the endoplasmic reticulum by the thyrocyte) and of polarized epithelium (the single layer of thyrocytes delimiting the follicle). Following endoplasmic reticulum stress, in thyroid cells the folding of thyroglobulin was disrupted. The mRNAs of unfolded protein response were induced or spliced (X-box binding protein-1). Differentiation was inhibited: mRNA levels of thyroid specific genes, and of thyroid transcription factors were dramatically downregulated, at least in part, transcriptionally. The dedifferentiating response was accompanied by an upregulation of mRNAs of antioxidant genes. Moreover, cadherin-1, and the thyroid (and kidney)-specific cadherin-16 mRNAs were downregulated, vimentin, and SNAI1 mRNAs were upregulated. In addition, loss of cortical actin and stress fibers formation were observed. Together, these data indicate that ER stress in thyroid cells induces dedifferentiation, loss of epithelial organization, shift towards a mesenchymal phenotype, and activation of the antioxidant response, highlighting, at the same time, a new and wide strategy to achieve survival following ER stress, and, as a sort of the other side of the coin, a possible new molecular mechanism of decline/loss of function leading to a deficit of thyroid hormones formation.openUlianich L.; Mirra P.; Garbi C.; Cali G.; Conza D.; Treglia A.S.; Miraglia A.; Punzi D.; Miele C.; Raciti G.A.; Beguinot F.; Consiglio E.; Di Jeso B.Ulianich, L.; Mirra, P.; Garbi, C.; Cali, G.; Conza, D.; Treglia, A. S.; Miraglia, A.; Punzi, D.; Miele, C.; Raciti, G. A.; Beguinot, F.; Consiglio, E.; Di Jeso, B
Proteomic Profiling Across Breast Cancer Cell Lines and Models
We performed quantitative proteomics on 60 human-derived breast cancer cell line models to a depth of ~13,000 proteins. The resulting high-throughput datasets were assessed for quality and reproducibility. We used the datasets to identify and characterize the subtypes of breast cancer and showed that they conform to known transcriptional subtypes, revealing that molecular subtypes are preserved even in under-sampled protein feature sets. All datasets are freely available as public resources on the LINCS portal. We anticipate that these datasets, either in isolation or in combination with complimentary measurements such as genomics, transcriptomics and phosphoproteomics, can be mined for the purpose of predicting drug response, informing cell line specific context in models of signalling pathways, and identifying markers of sensitivity or resistance to therapeutics
Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease
We have recently reported that a polymorphism in the cell division cycle (CDC2) gene, designated Ex6 + 7I/D, is associated with Alzheimer's disease (AD). The CDC2 gene is located on chromosome 10q21.1 close to the marker D10S1225 linked to AD. Active cdc2 accumulates in neurons containing neurofibrillary tangles (NFT), a process that can precede the formation of NFT. Therefore, CDC2 is a promising candidate susceptibility gene for AD. We investigated the possible effects of the CDC2 polymorphism on cerebrospinal fluid (CSF) biomarkers in AD patients. CDC2 genotypes were evaluated in relation to CSF protein levels of total tau, phospho-tau and beta-amyloid (1-42) in AD patients and control individuals, and in relation to the amount of senile plaques and NFT in the frontal cortex and in the hippocampus in patients with autopsy-proven AD and controls. The CDC2 Ex6 + 7I allele was associated with a gene dose-dependent increase of CSF total tau levels (F-2,F- 626 = 7.0, p = 0.001) and the homozygous CDC2Ex6 +7II genotype was significantly more frequent among AD patients compared to controls (p = 0.006, OR = 1.57, 95% CI 1.13-2.17). Our results provide further evidence for an involvement of cdc2 in the pathogenesis of AD. Copyright (C) 2005 S. Karger AG, Basel
Prospects for at CERN in NA62
The NA62 experiment will begin taking data in 2015. Its primary purpose is a
10% measurement of the branching ratio of the ultrarare kaon decay , using the decay in flight of kaons in an unseparated
beam with momentum 75 GeV/c.The detector and analysis technique are described
here.Comment: 8 pages for proceedings of 50 Years of CP
Hereditary Xerocytosis due to Mutations in PIEZO1 Gene Associated with Heterozygous Pyruvate Kinase Deficiency and Beta-Thalassemia Trait in Two Unrelated Families
Hereditary xerocytosis (HX) is a rare disorder caused by defects of RBC permeability, associated with haemolytic anaemia of variable degree and iron overload. It is sometimes misdiagnosed as hereditary spherocytosis or other congenital haemolytic anaemia. Splenectomy is contraindicated due to increased risk of thromboembolic complications. We report the clinical, haematological, and molecular characteristics of four patients from two unrelated Italian families affected by HX, associated with beta-thalassemia trait and heterozygous pyruvate kinase deficiency, respectively. Two patients had been splenectomised and displayed thrombotic episodes. All patients had iron overload in the absence of transfusion, two of them requiring iron chelation. The diagnosis of HX was confirmed by LoRRca Osmoscan analysis showing a left-shifted curve. PIEZO1 gene sequencing revealed the presence of mutation p.E2496ELE, showing that this is one of the most frequent mutations in this disease. The concomitant defects did not aggravate the clinical phenotype; however, in one patient, the initial diagnosis of pyruvate kinase deficiency delayed the correct diagnosis of HX for many years and resulted in splenectomy followed by thrombotic complications. The study underlines the importance of a precise diagnosis in HX, particularly in view of splenectomy, and the need of a molecular confirmation of suspected RBC enzymopathy
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