500 research outputs found
The BPAG1 locus: alternative splicing produces multiple isoforms with distinct cytoskeletal linker domains, including predominant isoforms in neurons and muscles
Bullous pemphigoid antigen 1 (BPAG1) is a member of the plakin family with cytoskeletal linker properties. Mutations in BPAG1 cause sensory neuron degeneration and skin fragility in mice. We have analyzed the BPAG1 locus in detail and found that it encodes different interaction domains that are combined in tissue-specific manners. These domains include an actin-binding domain (ABD), a plakin domain, a coiled coil (CC) rod domain, two different potential intermediate filament–binding domains (IFBDs), a spectrin repeat (SR)-containing rod domain, and a microtubule-binding domain (MTBD). There are at least three major forms of BPAG1: BPAG1-e (302 kD), BPAG1-a (615 kD), and BPAG1-b (834 kD). BPAG1-e has been described previously and consists of the plakin domain, the CC rod domain, and the first IFBD. It is the primary epidermal BPAG1 isoform, and its absence that is the likely cause of skin fragility in mutant mice. BPAG1-a is the major isoform in the nervous system and a homologue of the microtubule actin cross-linking factor, MACF. BPAG1-a is composed of the ABD, the plakin domain, the SR-containing rod domain, and the MTBD. The absence of BPAG1-a is the likely cause of sensory neurodegeneration in mutant mice. BPAG1-b is highly expressed in muscles, and has extra exons encoding a second IFBD between the plakin and SR-containing rod domains of BPAG1-a
Grooming of Dynamic Traffic in WDM Star and Tree Networks Using Genetic Algorithm
The advances in WDM technology lead to the great interest in traffic grooming
problems. As traffic often changes from time to time, the problem of grooming
dynamic traffic is of great practical value. In this paper, we discuss dynamic
grooming of traffic in star and tree networks. A genetic algorithm (GA) based
approach is proposed to support arbitrary dynamic traffic patterns, which
minimizes the number of ADM's and wavelengths. To evaluate the algorithm,
tighter bounds are derived. Computer simulation results show that our algorithm
is efficient in reducing both the numbers of ADM's and wavelengths in tree and
star networks.Comment: 15 page
Current reversal with type-I intermittency in deterministic inertia ratchets
The intermittency is investigated when the current reversal occurs in a
deterministic inertia ratchet system. To determine which type the intermittency
belongs to, we obtain the return map of velocities of particle using
stroboscopic recording, and numerically calculate the distribution of average
laminar length . The distribution follows the scaling law of , the characteristic relation of type-I
intermittency.Comment: 4 pages, 7 figure
Multiwavelength Study of M8.9/3B Solar Flare from AR NOAA 10960
We present a multi-wavelength analysis of a long duration white-light solar
flare (M8.9/3B) event that occurred on 4 June 2007 from NOAA AR 10960. The
flare was observed by several spaceborne instruments, namely SOHO/MDI,
Hinode/SOT, TRACE and STEREO/SECCHI. The flare was initiated near a small,
positive-polarity, satellite sunspot at the centre of the AR, surrounded by
opposite-polarity field regions. MDI images of the AR show considerable amount
of changes in a small positive-polarity sunspot of delta configuration during
the flare event. SOT/G-band (4305 A) images of the sunspot also suggest the
rapid evolution of the positive-polarity sunspot with highly twisted penumbral
filaments before the flare event, which were oriented in the counterclockwise
direction. It shows the change in orientation and also remarkable disappearance
of twisted penumbral filaments (~35-40%) and enhancement in umbral area
(~45-50%) during the decay phase of the flare. TRACE and SECCHI observations
reveal the successive activations of two helical twisted structures associated
with this sunspot, and the corresponding brightening in the chromosphere as
observed by the time-sequence images of SOT/Ca II H line (3968 A). The
secondary-helical twisted structure is found to be associated with the M8.9
flare event. The brightening starts 6-7 min prior to the flare maximum with the
appearance of secondary helical-twisted structure. The flare intensity
maximizes as this structure moves away from the AR. This twisted flux-tube
associated with the flare triggering, is found to be failed in eruption. The
location of the flare is found to coincide with the activation site of the
helical twisted structures. We conclude that the activations of successive
helical twists in the magnetic flux tubes/ropes plays a crucial role in the
energy build-up process and triggering of M-class solar flare without a CME.Comment: 22 pages, 12 figures, Accepted for Publication in Solar Physic
Effects of red grape, wild grape and black raspberry wines on ground pork during refrigerated storage
The effects of red grape, wild grape and black raspberry wines on the quality of ground pork during a 15 days refrigerated storage period were investigated. The levels of phenolic compounds were the highest in black raspberry wine (P0.05). The addition of 5% and 10% wine influenced the quality of ground pork by decreasing pH, inhibiting the progression of lipid oxidation and the formation of total volatile basic nitrogen (TVB-N), and stabilizing the red colour of the ground pork compared to control samples to which no wine was added. In ground pork, addition of red grape wine led to lower concentrations of thiobarbituric acid reactive substances (TBARS, 0.19–0.39 mg kg−1) and TVB-N values (69.1–119.9 mg kg−1) than wild grape (0.16–0.43 mg kg−1 and 72.0–194.1 mg kg−1, respectively) or black raspberry wine (0.33–0.58 mg kg−1 and 81.7–225.4 mg kg−1, respectively) up to 10 days of storage. Results from the present study suggested that the quality of ground pork was affected by wine type and storage period. These effects could be due to phenolic compounds as well as other chemical components of the wines
Study of Tau-pair Production in Photon-Photon Collisions at LEP and Limits on the Anomalous Electromagnetic Moments of the Tau Lepton
Tau-pair production in the process e+e- -> e+e-tau+tau- was studied using
data collected by the DELPHI experiment at LEP2 during the years 1997 - 2000.
The corresponding integrated luminosity is 650 pb^{-1}. The values of the
cross-section obtained are found to be in agreement with QED predictions.
Limits on the anomalous magnetic and electric dipole moments of the tau lepton
are deduced.Comment: 20 pages, 9 figures, Accepted by Eur. Phys. J.
Energy dependence of Cronin momentum in saturation model for and collisions
We calculate dependence of Cronin momentum for and
collisions in saturation model. We show that this dependence is consistent with
expectation from formula which was obtained using simple dimentional
consideration. This can be used to test validity of saturation model (and
distinguish among its variants) and measure dependence of saturation
momentum from experimental data.Comment: LaTeX2e, 12 pages, 8 figure
CP asymmetry in in a general two-Higgs-doublet model with fourth-generation quarks
We discuss the time-dependent CP asymmetry of decay in an
extension of the Standard Model with both two Higgs doublets and additional
fourth-generation quarks. We show that although the Standard Model with
two-Higgs-doublet and the Standard model with fourth generation quarks alone
are not likely to largely change the effective from the decay of
, the model with both additional Higgs doublet and
fourth-generation quarks can easily account for the possible large negative
value of without conflicting with other experimental
constraints. In this model, additional large CP violating effects may arise
from the flavor changing Yukawa interactions between neutral Higgs bosons and
the heavy fourth generation down type quark, which can modify the QCD penguin
contributions. With the constraints obtained from processes
such as and , this model can lead to the
effective to be as large as in the CP asymmetry of .Comment: 13 pages, 5 figures, references added, to appear in Eur.Phys.J.
Search for composite and exotic fermions at LEP 2
A search for unstable heavy fermions with the DELPHI detector at LEP is
reported. Sequential and non-canonical leptons, as well as excited leptons and
quarks, are considered. The data analysed correspond to an integrated
luminosity of about 48 pb^{-1} at an e^+e^- centre-of-mass energy of 183 GeV
and about 20 pb^{-1} equally shared between the centre-of-mass energies of 172
GeV and 161 GeV. The search for pair-produced new leptons establishes 95%
confidence level mass limits in the region between 70 GeV/c^2 and 90 GeV/c^2,
depending on the channel. The search for singly produced excited leptons and
quarks establishes upper limits on the ratio of the coupling of the excited
fermio
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