Re-imagining Japan after Fukushima

"The 2011 Tōhoku earthquake, tsunami and Fukushima nuclear disaster (collectively referred to as ‘3.11’, the date of the earthquake), had a lasting impact on Japan’s identity and global image. In its immediate aftermath, mainstream media presented the country as a disciplined, resilient and composed nation, united in the face of a natural disaster. However, 3.11 also drew worldwide attention to the negative aspects of Japanese government and society, thought to have caused the unresolved situation at Fukushima. Spurred by heightened emotions following the triple disaster, the Japanese became increasingly polarised between these two views of how to represent themselves. How did literature and popular culture respond to this dilemma? Re-imagining Japan after Fukushima attempts to answer that question by analysing how Japan was portrayed in post-3.11 fiction. Texts are selected from the Japanese, English and French languages, and the portrayals are also compared with those from non-fiction discourse. This book argues that cultural responses to 3.11 had a significant role to play in re-imagining Japan after Fukushima.

Importance of Child Emotion Regulation for Prevention of Internalized and Externalized Problems

Emotion regulation is viewed as an integral process of child competence, showing whether a child is ready for challenges of interaction, and contact with self and others. It is defined as successful and effortful internal adjustment of emotional arousal with the intention of good social adaptation and harmonious functioning. Aims of this study were to determine gender differences in emotion regulation and observed internalized and externalized behavioural problems of school-age children, assess the correlations between emotion regulation and behavioural problems, and examine the relations between different levels of emotion regulation and observed behaviours. The study included 200 children (ages 6 to 8). At the beginning of first grade teachers completed measures of children’s social-emotional functioning as well as their internalized and externalized behavioural problems. The results showed significant correlations between emotion regulation and observed internalized and externalized problems (internalized symptoms, lack of attention, hyperactive-impulsive behaviour, peer problems, oppositional aggressive behaviour, and conduct problems). It was also found that children with lower levels of emotion regulation expressed more severe internalized and externalized behavioural problems and vice versa. The findings were discussed with respect to the importance of sustainable delivery of effective and evidence-based prevention strategies in an education system with particular emphasis on social-emotional learning approaches where core program components address emotion regulation skills

On zeros of some analytic spaces of area Nevanlinna type in halfplane

We introduce two new scales of spaces of Nevanlinna type in a halfplane C+ and provide descriptions of their zero sets and based on it we present parametric representations of these classes

Hypoxia and Ezrin Expression in Primary Melanoma Have High Prognostic Relevance

Hypoxia affects tumor aggressiveness and activates pathways associated with epithelial mesenchymal transition (EMT) which are crucial for tumor progress. In this study, the correlation of hypoxia and EMT with sentinel lymph node status and tumor-specific survival was investigated in primary melanomas. CD34 for capillary count and Hypoxia inducible factor-1α (HIF-1α) as hypoxia indicators as well as Ezrin and L1-Cell Adhesion Molecule (L1CAM), both critical proteins contributing to EMT, were analyzed using immunohistochemistry in 49 melanoma patients with long follow-up (F/U, mean 110 months; range 12-263 months). We found a significant correlation between Breslow tumor thickness and Ezrin expression (p = 0.018). L1CAM expression in primary melanoma was significantly associated with HIF-1α expression (p < 0.0001) and sentinel lymph node metastasis (p = 0.011). Furthermore, low capillary count, reflecting hypoxic condition, was significantly associated with Ezrin expression (p = 0.047) and decreased tumor-specific survival (p = 0.035). In addition, patients with high Ezrin expression in their primary melanoma had a dramatic loss of life early in their F/U period (mean survival time 29 months; range 15-44 month). Our results highlight the relevance of Ezrin, L1CAM and HIF-1α as prognostic markers in melanoma patients. Additionally, we demonstrate that hypoxia in primary melanoma affects EMT and is at least partly responsible for early metastatic dissemination

Serotonergic innervation of the amygdala is increased in autism spectrum disorder and decreased in Williams syndrome.

BackgroundWilliams syndrome (WS) and autism spectrum disorder (ASD) are neurodevelopmental disorders that demonstrate overlapping genetic associations, dichotomous sociobehavioral phenotypes, and dichotomous pathological differences in neuronal distribution in key social brain areas, including the prefrontal cortex and the amygdala. The serotonergic system is critical to many processes underlying neurodevelopment and is additionally an important neuromodulator associated with behavioral variation. The amygdala is heavily innervated by serotonergic projections, suggesting that the serotonergic system is a significant mediator of neuronal activity. Disruptions to the serotonergic system, and atypical structure and function of the amygdala, are implicated in both WS and ASD.MethodsWe quantified the serotonergic axon density in the four major subdivisions of the amygdala in the postmortem brains of individuals diagnosed with ASD and WS and neurotypical (NT) brains.ResultsWe found opposing directions of change in serotonergic innervation in the two disorders, with ASD displaying an increase in serotonergic axons compared to NT and WS displaying a decrease. Significant differences (p < 0.05) were observed between WS and ASD data sets across multiple amygdala nuclei.LimitationsThis study is limited by the availability of human postmortem tissue. Small sample size is an unavoidable limitation of most postmortem human brain research and particularly postmortem research in rare disorders.ConclusionsDifferential alterations to serotonergic innervation of the amygdala may contribute to differences in sociobehavioral phenotype in WS and ASD. These findings will inform future work identifying targets for future therapeutics in these and other disorders characterized by atypical social behavior