Periodontitis and diabetes: a two-way relationship

Periodontitis is a common chronic inflammatory disease characterised by destruction of the supporting structures of the teeth (the periodontal ligament and alveolar bone). It is highly prevalent (severe periodontitis affects 10–15% of adults) and has multiple negative impacts on quality of life. Epidemiological data confirm that diabetes is a major risk factor for periodontitis; susceptibility to periodontitis is increased by approximately threefold in people with diabetes. There is a clear relationship between degree of hyperglycaemia and severity of periodontitis. The mechanisms that underpin the links between these two conditions are not completely understood, but involve aspects of immune functioning, neutrophil activity, and cytokine biology. There is emerging evidence to support the existence of a two-way relationship between diabetes and periodontitis, with diabetes increasing the risk for periodontitis, and periodontal inflammation negatively affecting glycaemic control. Incidences of macroalbuminuria and end-stage renal disease are increased twofold and threefold, respectively, in diabetic individuals who also have severe periodontitis compared to diabetic individuals without severe periodontitis. Furthermore, the risk of cardiorenal mortality (ischaemic heart disease and diabetic nephropathy combined) is three times higher in diabetic people with severe periodontitis than in diabetic people without severe periodontitis. Treatment of periodontitis is associated with HbA1c reductions of approximately 0.4%. Oral and periodontal health should be promoted as integral components of diabetes management

Bayesian Calculation of Optimal Burn-in Time Using the Joint Criteria of Cost and Delivered Reliability

Burn-in is a quality control process used to minimize the warranty cost of a product by screening out defective products through prior operation for a period of time before sale. Two decision criteria used to determine the optimal burn-in time are the maximization of the reliability of the delivered product and the minimization of the total cost, which are composed of the cost of burn-in process and the cost of warranty claims. Because of uncertainty regarding the underlying lifetime distribution of the product, both the product reliability and the total cost are random variables. In this paper, the uncertainty in reliability and cost is quantified by use of Bayesian analysis. The joint distribution of reliability and cost is inferred from the uncertainty distribution of the parameters of the product lifetime distribution. To incorporate the uncertainty in reliability and cost as well as the tradeoff between them into the selection of optimal burn-in time, the joint utility function of reliability and cost is constructed using the joint distribution of reliability and cost. The optimal burn-in time is selected as the time that maximizes the joint utility function. Copyright (C) 2010 John Wiley & Sons, Ltd

Executive attention impairment in first-episode schizophrenia

<p>Abstract</p> <p>Background</p> <p>We compared the attention abilities of a group of first-episode schizophrenia (FES) patients and a group of healthy participants using the Attention Network Test (ANT), a standard procedure that estimates the functional state of three neural networks controlling the efficiency of three different attentional behaviors, i.e., alerting (achieving and maintaining a state of high sensitivity to incoming stimuli), orienting (ability to select information from sensory input), and executive attention (mechanisms for resolving conflict among thoughts, feelings, and actions).</p> <p>Methods</p> <p>We evaluated 22 FES patients from 17 to 29 years of age with a recent history of a single psychotic episode treated only with atypical neuroleptics, and 20 healthy persons matched with FES patients by sex, age, and educational level as the control group. Attention was estimated using the ANT in which participants indicate whether a central horizontal arrow is pointing to the left or the right. The central arrow may be preceded by spatial or temporal cues denoting where and when the arrow will appear, and may be flanked by other arrows (hereafter, flankers) pointing in the same or the opposite direction.</p> <p>Results</p> <p>The efficiency of the alerting, orienting, and executive networks was estimated by measuring how reaction time was influenced by congruency between temporal, spatial, and flanker cues. We found that the control group only demonstrated significantly greater attention efficiency than FES patients in the executive attention network.</p> <p>Conclusions</p> <p>FES patients are impaired in executive attention but not in alerting or orienting attention, suggesting that executive attention deficit may be a primary impairment during the progression of the disease.</p