Programa académico de doctorado en gestión pública y gobernabilidad

The purpose of the study was to know the comprehensive incentive plan as it contributes to the municipal management of the district of Shamboyacu, Picota Province, 2021. The study corresponds to basic research, with a systematic review research design, for the data collection procedures was carried out by means of the bibliographic and systematic search of documents where scientific articles were selected in the search engines of Academic Google, Dialnet, Redalyc, Scielo, EBSCO, the same ones that have been ordered in an Excel matrix to facilitate its quick localization; in total 22 articles were selected. In the analysis technique the document review was used and as a tool the data collection form was used after the analysis of the results and the conclusions obtained according to the objective has been determined that, during the review of articles, qualitative and quantitative research, even of a mixed nature, was found. The Comprehensive Incentive Plan helps municipal management to develop, but it is not only its implementation that will meet all the current shortcomings, the commitment of public officials to the achievement of goals and the permanence of a good public service will be the incentive to encourage this management to reach the next level. Therefore, there should be continued interest and capacity to coordinate and meet IP targets in order to continue to receive this incentive.El propósito de estudio fue conocer el plan de incentivo integral como contribuye en la gestión municipal del distrito de Shamboyacu, Provincia de Picota, 2021. El estudio corresponde a una investigación básica, con un diseño de investigación de revisión sistemática, para los procedimientos de recolección de datos se llevó a cabo mediante la búsqueda bibliográfica y sistemática de documentos donde fueron seleccionados artículos científicos en los buscadores de Google Académico, Dialnet, Redalyc, Scielo, EBSCO, los mismos que han sido ordenados en una matriz Excel para facilitar su rápida localización; en total fueron seleccionados 22 artículos. En la técnica de análisis se utilizó la revisión documental y como instrumento se empleó la ficha de recolección de datos luego del análisis de los resultados y las conclusiones obtenidas de acuerdo al objetivo se ha determinado que, durante la revisión de artículos, se encontraron investigaciones tanto cualitativas como cuantitativas, hasta de carácter mixto. El Plan de Incentivos Integral ayuda a la gestión municipal a desarrollarse, pero no es su sola aplicación la que cumplirá con todas las deficiencias que se tienen actualmente, el compromiso de los funcionarios púbicos para el cumplimiento de metas y la permanencia de un buen servicio público será el incentivo para impulsar a que esta gestión pueda llegar al siguiente nivel. Por tanto, se debe mantener un constante interés y estar capacitado para coordinar y cumplir las metas correspondientes al PI con tal de seguir recibiendo este incentivo

Una mirada a la gestión municipal para generar condiciones socio sanitarias

The objective of the research was to determine the characteristics of municipal management to generate socio-sanitary conditions, the type of research was basic, descriptive non-experimental design with systematic review. The characteristics that stand out in municipal management are the diagnosis, training, description of the actions of the community and social actors, the formation of the issue, the population and the institutional dialogue to establish a comprehensive health analysis and effective intervention. In addition, it is decisive in the generation of socio-sanitary development for the benefit of the population in a territorial management framework. Knowledge of behavioral, socioeconomic and demographic factors influence management and recycling waste, household behavior, and other municipal waste producers that affect health. The economic resources of local governments respond to the fulfillment of objectives based on the axes of social, productive, institutional and economic development, which in turn respond to the budget for results and compliance goals are established. In conclusion, health is complex, there is a decentralization policy aimed, however, the municipalization of health and education has not yet been achieved in response to territorial management. Local governments use digital tools that facilitate the management and control of health resources.La investigation tuvo por objetivo determinar las características de la gestión municipal para generar condiciones socio sanitarias, el tipo de investigación fue básica de diseño no experimental descriptivo con revisión sistemática. Las características que resaltan en la gestión municipal son el diagnóstico, capacitación, descripción de las acciones de la comunidad y actores sociales, la formación del tema, la población y el diálogo institucional para establecer un análisis integral de salud y una intervención efectiva. Además, es determinante en la generación del desarrollo socio sanitario a beneficio de la población en un marco de gestión territorial. El conocimiento de los factores conductuales, socioeconómicos y demográficos influyen en los residuos de administración y reciclaje, comportamiento de los hogares, y otros productores de residuos municipales que afectan la salud. Los recursos económicos de los gobiernos locales responden al cumplimiento de objetivos en base a los ejes del desarrollo social, productivo, institucional y económico, que a su vez responde al presupuesto por resultados y se establecen metas de cumplimiento. En conclusión, la salud es compleja, existe una política de descentralización encaminada sin embargo la municipalización de la salud y educación aún no se alcanza en respuesta a la gestión territorial. Los gobiernos locales utilizan herramientas digitales que faciliten el manejo y control de los recursos en salud

Very preterm birth is a risk factor for increased systolic blood pressure at a young adult age

Children born very prematurely who show intrauterine growth retardation (IUGR) are suggested to be at risk of developing high blood pressure as adults. Renal function may already be impaired by young adult age. To study whether very preterm birth affects blood pressure in young adults, we measured 24-h ambulatory blood pressure (Spacelabs™ 90207 device) and renin concentration in 50 very premature individuals (<32 weeks of gestation), either small (SGA) or appropriate (AGA) for gestational age (21 SGA, 29 AGA), and 30 full-term controls who all were aged 20 years at time of measurement. The mean (standard deviation) daytime systolic blood pressure in SGA and AGA prematurely born individuals, respectively, was 122.7 (8.7) and 123.1 (8.5) mmHg. These values were, respectively, 3.6 mmHg [95% confidence interval (CI) −0.9 to 8.0] and 4.2 mmHg (95% CI 0.4−8.0) higher than in controls [119.6 (7.6)]. Daytime diastolic blood pressure and nighttime blood pressure did not differ between groups. We conclude that individuals born very preterm have higher daytime systolic blood pressure and higher risk of hypertension at a young adult age

Maternal obesity support services: a qualitative study of the perspectives of women and midwives

Background - Twenty percent of pregnant women in the UK are obese (BMI ≥ 30 kg/m2), reflecting the growing public health challenge of obesity in the 21st century. Obesity increases the risk of adverse outcomes during pregnancy and birth and has significant cost implications for maternity services. Gestational weight management strategies are a high priority; however the evidence for effective, feasible and acceptable weight control interventions is limited and inconclusive. This qualitative study explored the experiences and perceptions of pregnant women and midwives regarding existing support for weight management in pregnancy and their ideas for service development. Methods - A purposive sample of 6 women and 7 midwives from Doncaster, UK, participated in two separate focus groups. Transcripts were analysed thematically. Results - Two overarching themes were identified, 'Explanations for obesity and weight management' and 'Best care for pregnant women'. 'Explanations' included a lack of knowledge about weight, diet and exercise during pregnancy; self-talk messages which excused overeating; difficulties maintaining motivation for a healthy lifestyle; the importance of social support; stigmatisation; and sensitivity surrounding communication about obesity between midwives and their clients. 'Best care' suggested that weight management required care which was consistent and continuous, supportive and non-judgemental, and which created opportunities for interaction and mutual support between obese pregnant women. Conclusions - Women need unambiguous advice regarding healthy lifestyles, diet and exercise in pregnancy to address a lack of knowledge and a tendency towards unhelpful self-talk messages. Midwives expressed difficulties in communicating with their clients about their weight, given awareness that obesity is a sensitive and potentially stigmatising issue. This indicates more could be done to educate and support them in their work with obese pregnant women. Motivation and social support were strong explanatory themes for obesity and weight management, suggesting that interventions should focus on motivational strategies and social support facilitation

The Quantum Internet

Quantum networks offer a unifying set of opportunities and challenges across exciting intellectual and technical frontiers, including for quantum computation, communication, and metrology. The realization of quantum networks composed of many nodes and channels requires new scientific capabilities for the generation and characterization of quantum coherence and entanglement. Fundamental to this endeavor are quantum interconnects that convert quantum states from one physical system to those of another in a reversible fashion. Such quantum connectivity for networks can be achieved by optical interactions of single photons and atoms, thereby enabling entanglement distribution and quantum teleportation between nodes.Comment: 15 pages, 6 figures Higher resolution versions of the figures can be downloaded from the following link: http://www.its.caltech.edu/~hjkimble/QNet-figures-high-resolutio

G-CSFR Ubiquitination Critically Regulates Myeloid Cell Survival and Proliferation

The granulocyte colony-stimulating factor receptor (G-CSFR) is a critical regulator of granulopoiesis. Mutations in the G-CSFR in patients with severe congenital neutropenia (SCN) transforming to acute myelogenous leukemia (AML) have been shown to induce hypersensitivity and enhanced growth responses to G-CSF. Recent studies have demonstrated the importance of the ubiquitin/proteasome system in the initiation of negative signaling by the G-CSFR. To further investigate the role of ubiquitination in regulating G-CSFR signaling, we generated a mutant form of the G-CSFR (K762R/G-CSFR) which abrogates the attachment of ubiquitin to the lysine residue at position 762 of the G-CSFR that is deleted in the Δ716 G-CSFR form isolated from patients with SCN/AML. In response to G-CSF, mono-/polyubiquitination of the G-CSFR was impaired in cells expressing the mutant K762R/G-CSFR compared to cells transfected with the WT G-CSFR. Cells stably transfected with the K762R/G-CSFR displayed a higher proliferation rate, increased sensitivity to G-CSF, and enhanced survival following cytokine depletion, similar to previously published data with the Δ716 G-CSFR mutant. Activation of the signaling molecules Stat5 and Akt were also increased in K762R/G-CSFR transfected cells in response to G-CSF, and their activation remained prolonged after G-CSF withdrawal. These results indicate that ubiquitination is required for regulation of G-CSFR-mediated proliferation and cell survival. Mutations that disrupt G-CSFR ubiquitination at lysine 762 induce aberrant receptor signaling and hyperproliferative responses to G-CSF, which may contribute to leukemic transformation

Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: A cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis (MESA)

Background: Prior studies using creatinine-based estimated glomerular filtration rate (eGFR) have found limited associations between kidney function and markers of inflammation. Using eGFR and cystatin C, a novel marker of kidney function, the authors investigated the association of kidney function with multiple biomarkers in a diverse cohort. Methods: The Multi-Ethnic Study of Atherosclerosis consists of 6,814 participants of white, African-American, Hispanic, and Chinese descent, enrolled from 2000-2002 from six U.S. communities. Measurements at the enrollment visit included serum creatinine, cystatin C, and six inflammatory and procoagulant biomarkers. Creatinine-based eGFR was estimated using the fourvariable Modification of Diet in Renal Disease equation, and chronic kidney disease was defined by an eGFR less than 60 mL/min/1.73 m2. Results: Adjusted partial correlations between cystatin C and all biomarkers were statistically significant: C-reactive protein (r = 0.08), interleukin-6 (r = 0.16), tumor necrosis factor-a soluble receptor 1 (TNF-aR1; r = 0.75), intercellular adhesion molecule-1 (r = 0.21), fibrinogen (r = 0.14), and factor VIII (r = 0.11; two-sided p less than 0.01 for all). In participants without chronic kidney disease, higher creatinine-based eGFR was associated only with higher TNF-aR1 levels. Conclusion: In a cohort characterized by ethnic diversity, cystatin C was directly associated with multiple procoagulant and inflammatory markers. Creatinine-based eGFR had similar associations with these biomarkers among subjects with chronic kidney disease.This research was supported by contracts N01-HC-95159 through N01-HC-95169 from the National Heart, Lung, and Blood Institute (NHLBI)