The effect of distance on reaction time in aiming movements

Target distance affects movement duration in aiming tasks but its effect on reaction time (RT) is poorly documented. RT is a function of both preparation and initiation. Experiment 1 pre-cued movement (allowing advanced preparation) and found no influence of distance on RT. Thus, target distance does not affect initiation time. Experiment 2 removed pre-cue information and found that preparing a movement of increased distance lengthens RT. Experiment 3 explored movements to targets of cued size at non-cued distances and found size altered peak speed and movement duration but RT was influenced by distance alone. Thus, amplitude influences preparation time (for reasons other than altered duration) but not initiation time. We hypothesise that the RT distance effect might be due to the increased number of possible trajectories associated with further targets: a hypothesis that can be tested in future experiments

Bimanual grasp planning reflects changing rather than fixed constraint dominance

We studied whether motor-control constraints for grasping objects that are moved to new positions reflect a rigid constraint hierarchy or a flexible constraint hierarchy. In two experiments, we asked participants to move two plungers from the same start locations to different target locations (both high, both low, or one high and one low). We found that participants grasped the plungers symmetrically and at heights that ensured comfortable or easy-to-control end postures when the plungers had the same target heights, but these grasp tendencies were reduced when the plungers had different target heights. In addition, when the plungers had different mass distributions, participants behaved in ways that suggested still-different emphases of the relevant grasp constraints. When the plungers had different mass distributions, participants sacrificed bimanual symmetry for end-state comfort. The results suggest that bimanual grasp planning relies on a flexible rather than static hierarchy. Different constraints take on different degrees of importance depending on the nature of the task and on the level of task experience. The results have implications for the understanding of perceptual-motor skill learning. It may be that one mechanism underlying such learning is changing the priorities of task constraints

CNS Penetration of Intrathecal-Lumbar Idursulfase in the Monkey, Dog and Mouse: Implications for Neurological Outcomes of Lysosomal Storage Disorder

A major challenge for the treatment of many central nervous system (CNS) disorders is the lack of convenient and effective methods for delivering biological agents to the brain. Mucopolysaccharidosis II (Hunter syndrome) is a rare inherited lysosomal storage disorder resulting from a deficiency of iduronate-2-sulfatase (I2S). I2S is a large, highly glycosylated enzyme. Intravenous administration is not likely to be an effective therapy for disease-related neurological outcomes that require enzyme access to the brain cells, in particular neurons and oligodendrocytes. We demonstrate that intracerebroventricular and lumbar intrathecal administration of recombinant I2S in dogs and nonhuman primates resulted in widespread enzyme distribution in the brain parenchyma, including remarkable deposition in the lysosomes of both neurons and oligodendrocytes. Lumbar intrathecal administration also resulted in enzyme delivery to the spinal cord, whereas little enzyme was detected there after intraventricular administration. Mucopolysaccharidosis II model is available in mice. Lumbar administration of recombinant I2S to enzyme deficient animals reduced the storage of glycosaminoglycans in both superficial and deep brain tissues, with concurrent morphological improvements. The observed patterns of enzyme transport from cerebrospinal fluid to the CNS tissues and the resultant biological activity (a) warrant further investigation of intrathecal delivery of I2S via lumbar catheter as an experimental treatment for the neurological symptoms of Hunter syndrome and (b) may have broader implications for CNS treatment with biopharmaceuticals

Individual differences in motor planning during a multi-segment object manipulation task

Seegelke C, Hughes C, Schütz C, Schack T. Individual differences in motor planning during a multi-segment object manipulation task. Experimental Brain Research. 2012;222(1-2):125-136.Research has demonstrated that people will adopt initially awkward grasps if they afford more comfortable postures at the end of the movement. This end-state comfort effect provides evidence that humans represent future posture states and select appropriate grasps in anticipation of these postures. The purpose of the study was to examine to what extent the final action goal of a task influences motor planning of preceding segments, and whether grasp postures are planned to optimize end-state comfort during a three-segment action sequence in which two objects are manipulated, and participants can select from a continuous range of possible grasp postures. In the current experiment, participants opened a drawer, grasped an object from inside the drawer, and placed it on a table in one of the three target orientations (0A degrees, 90A degrees, or 180A degrees object rotation required). Grasp postures during the initial movement segment (drawer opening) were not influenced by the final action goal (i.e., required target orientation). In contrast, both the intermediate (i.e., object grasping) and the final movement segment (i.e., object placing) were influenced by target orientation. In addition, participants adopted different strategies to achieve the action goal when the object required 180A degrees rotation, with 42 % of participants prioritizing intermediate-state comfort and 58 % prioritizing end-state comfort. The results indicate that individuals optimize task performance by selecting lower level constraints that allow for successful completion of the action goal and that the selection of these constraints is dependent upon contextual, environmental, and internal influences