CARET analysis of multithreaded programs

Dynamic Pushdown Networks (DPNs) are a natural model for multithreaded programs with (recursive) procedure calls and thread creation. On the other hand, CARET is a temporal logic that allows to write linear temporal formulas while taking into account the matching between calls and returns. We consider in this paper the model-checking problem of DPNs against CARET formulas. We show that this problem can be effectively solved by a reduction to the emptiness problem of B\"uchi Dynamic Pushdown Systems. We then show that CARET model checking is also decidable for DPNs communicating with locks. Our results can, in particular, be used for the detection of concurrent malware.Comment: Pre-proceedings paper presented at the 27th International Symposium on Logic-Based Program Synthesis and Transformation (LOPSTR 2017), Namur, Belgium, 10-12 October 2017 (arXiv:1708.07854

Geochemistry of the Panzhihua Mafic Layered Intrusion (SW China): Petrogenetic Implications for its Giant V-Ti-Magnetite Deposit

published_or_final_versio

Origin of the Yangliuping Ni-Cu-(PGE) Sulfide Deposit Within the Emeishan Large Igneous Province, SW China

published_or_final_versio

Tectonic Settings of Magmatic Sulfide Deposits in China

published_or_final_versio

Geochemical Constrains on Nature of Source Region of The Late Permian Emeishan Continental Flood Basalts, SW China

Abstract in http://www.lpi.usra.edu/meetings/gold2001/pdf/3488.pd

Electronic, mobile and telehealth tools for vulnerable patients with chronic disease: A systematic review and realist synthesis

Objectives The objective of this review was to assess the benefit of using electronic, mobile and telehealth tools for vulnerable patients with chronic disease and explore the mechanisms by which these impact patient self-efficacy and self-management. Design We searched MEDLINE, all evidence-based medicine, CINAHL, Embase and PsychINFO covering the period 2009 to 2018 for electronic, mobile or telehealth interventions. Quality was assessed according to rigour and relevance. Those studies providing a richer description ('thick') were synthesised using a realist matrix. Setting and participants Studies of any design conducted in community-based primary care involving adults with one or more diagnosed chronic health condition and vulnerability due to demographic, geographic, economic and/or cultural characteristics. Results Eighteen trials were identified targeting a range of chronic conditions and vulnerabilities. The data provided limited insight into the mechanisms underpinning these interventions, most of which sought to persuade vulnerable patients into believing they could self-manage their conditions through improved symptom monitoring, education and support and goal setting. Patients were relatively passive in the interaction, and the level of patient response attributed to their intrinsic level of motivation. Health literacy, which may be confounded with motivation, was only measured in one study, and eHealth literacy was not assessed. Conclusions Research incorporating these tools with vulnerable groups is not comprehensive. Apart from intrinsic motivation, health literacy may also influence the reaction of vulnerable groups to technology. Social persuasion was the main way interventions sought to achieve better self-management. Efforts to engage patients by healthcare providers were lower than expected. Use of social networks or other eHealth mechanisms to link patients and provide opportunities for vicarious experience could be further explored in relation to vulnerable groups. Future research could also assess health and eHealth literacy and differentiate the specific needs for vulnerable groups when implementing health technologies

SHRIMP zircon geochronology of the Emeishan Large Igneous Province (SW China): implications for double mass extinctions in Late Permian

Abstract in http://www.lpi.usra.edu/meetings/gold2001/pdf/3519.pd

Late Permian rifting of the South China Craton caused by the Emeishan mantle plume?

Stratigraphic relationships and bulk-rock geochemical data indicate that Upper Permian metabasalts in the Songpan-Ganzi and Yidun terranes, on the eastern margin of the Tibetan Plateau, are part of the Emeishan large igneous province, which is believed to have formed from the Emeishan mantle plume. Eruption of the Emeishan basalts at 260 Ma was coincident with rifting of the western margin of the South China Craton to form the Songpan-Ganzi ocean basin. The spatial and temporal coincidence between basalt eruption and continental rifting, as well as regional doming prior to eruption, suggest that continental break-up was a response to the Late Permian Emeishan plume. The Songpan-Ganzi ocean basin was rapidly filled with Triassic flysch deposits, then deformed and uplifted during Mesozoic collision between the North China and South China Blocks and the Tertiary collision of India and Eurasia.published_or_final_versio

Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing.

Cytotoxic T cells (CTL) represent the major defense mechanism against the spread of virus infection. It is believed that the pore-forming protein, perforin, facilitates the entry of a series of serine proteases (particularly granzyme B) into the target cell which ultimately leads to DNA fragmentation and apoptosis. We demonstrate here that during CTL-mediated cytolysis the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs), an enzyme implicated in the repair of double strand breaks in DNA, is specifically cleaved by an interleukin (IL)-1 beta-converting enzyme (ICE)-like protease. A serine protease inhibitor, 3,4-dichloroisocoumarin (DCl), which is known to block granzyme B activity, inhibited CTL-induced apoptosis and prevented the degradation of DNA-PKcs in cells but failed to prevent the degradation of purified DNA-PKcs by CTL extracts. However, Tyr-Val-Ala-Asp-CH2Cl (YVAD-CMK) and other cysteine protease inhibitors prevented the degradation of purified DNA-PKcs by CTL extracts. Furthermore, incubation of DNA-PKcs with granzyme B did not produce the same cleavage pattern observed in cells undergoing apoptosis and when this substrate was incubated with either CTL extracts or the ICE-like protease, CPP32. Sequence analysis revealed that the cleavage site in DNA-PKcs during CTL killing was the same as that when this substrate was exposed to CPP32. This study demonstrates for the first time that the cleavage of DNA-PKcs in this intact cell system is exclusively due to an ICE-like protease