VACCINATION PRACTICES OF ADULT FAMILIAL MEDITERRANEAN FEVER PATIENTS IN TURKEY.

[Abstract Not Available

The effects of levamisole and albendazole on spermatological parameters, testosterone levels, and sperm DNA damage in Saanen bucks

This study aimed to investigate the effect of levamisole and albendazole on spermatological parameters, testosterone levels, and sperm DNA damage in Saanen bucks. For this purpose, twenty-four Saanen bucks were divided into three groups as control, levamisole, and albendazole administration group. The control group received only water (20 ml, oral), the levamisole group received 7.5 mg/kg of levamisole (2 oral tablets once daily for 2 days) + water (20 ml, oral), and the albendazole group received 7.5 mg/kg of albendazole (1 oral tablet) + water (20 ml, oral). Semen and blood samples were collected from all animals, both before drug application (day 0) and within a 2-day interval after drug application between day 1 (day of the treatment) and day 11. Spermatological parameters were evaluated immediately after collection. Testosterone levels were also measured from the blood samples with ELISA. Sperm DNA damage was determined with comet assay. The present research showed that especially albendazole administration decreased spermatological parameters and levamisole administration decreased testosterone levels. Significant sperm DNA damage was seen after both albendazole and levamisole administration. As a result, albendazole and levamisole administration should be used carefully on Saanen bucks, especially during the breeding season

Familial mediterranean fever patients may have unmet needs for the treatments of exertional leg pain and enthesitis

Introduction: Exertional leg pain (ELP) and enthesitis are musculoskeletal findings in familial Mediterranean fever (FMF). They are not accepted as principal treatment targets. In this study, we assessed the effectiveness of treatments on ELP and enthesitis. Material and methods: We have included 218 FMF patients to the study. We retrospectively compared the FMF attacks' frequency, duration and intensity (FMF attack VAS score) and levels of ELP VAS and enthesitis VAS scores between pre-treatment stage and while patients were on treatment at the last visit. Results: Forty-nine (22.5%) and 52 (23.9%) of the patients had enthesitis and ELP respectively. All patients were on colchicine treatment. Serositis attacks respond the treatments significantly. Moreover, both ELP VAS scores (p = 0.002) and enthesis VAS scores (p = 0.17) were improved with treatment. But only improvement in ELP VAS scores was significant. Conclusion: FMF treatments had favourable effect on ELP and enthesitis in FMF patients. However, the response rates would be inadequate. Therefore, there would be unmet need for treatment of both conditions.(c) 2021 Elsevier Espana, S.L.U. and Sociedad Espanola de Reumatologia yColegio Mexicano de Reumatologia. All rights reserve

MUSCULOSKELETAL VARIANT OF FAMILIAL MEDITERRANEAN FEVER MAY HAVE MORE SEVERE DISEASE

[No Abstract Available

Los pacientes con fiebre mediterránea familiar podrían tener necesidades no satisfechas de tratamiento del dolor en piernas con el esfuerzo y entesitis]

Introduction: Exertional leg pain (ELP) and enthesitis are musculoskeletal findings in familial Mediterranean fever (FMF). They are not accepted as principal treatment targets. In this study, we assessed the effectiveness of treatments on ELP and enthesitis. Material and methods: We have included 218 FMF patients to the study. We retrospectively compared the FMF attacks’ frequency, duration and intensity (FMF attack VAS score) and levels of ELP VAS and enthesitis VAS scores between pre-treatment stage and while patients were on treatment at the last visit. Results: Forty-nine (22.5%) and 52 (23.9%) of the patients had enthesitis and ELP respectively. All patients were on colchicine treatment. Serositis attacks respond the treatments significantly. Moreover, both ELP VAS scores (p = 0.002) and enthesis VAS scores (p = 0.17) were improved with treatment. But only improvement in ELP VAS scores was significant. Conclusion: FMF treatments had favourable effect on ELP and enthesitis in FMF patients. However, the response rates would be inadequate. Therefore, there would be unmet need for treatment of both conditions. © 2021 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatologí

Adverse effects of oxytetracycline and enrofloxacin on the fertility of Saanen bucks

This study aimed to determine the adverse effects of oxytetracycline and enrofloxacin application on the fertility of Saanen bucks. For this purpose, twenty-four bucks were divided into three groups. Group I (control group) received only 5 ml of 0.9% NaCl for 7 days, group II was given a single dose of 20 mg/kg oxytetracycline and group III was given at a dose of 2.5 mg/kg per day for 7 days intramuscularly. Serum and semen samples were collected from the bucks at post-treatment 1, 3, 5, 7, and 9 days and examined spermatological parameters (quantity, motility, density, abnormal sperm ratio, and live-dead sperm ratio), serum testosterone levels (with ELISA) and sperm DNA parameters (with Comet assay). The results showed no change in sperm volume, abnormal sperm rate, and dead-live sperm ratio in group II and III following oxytetracycline and enrofloxacin administration. However, a decrease in sperm density, sperm motility, mass activity, and testosterone levels, and an increase in sperm DNA damage were detected. These spermatological parameters (density, motility, mass activity) and testosterone levels were less decreased and sperm DNA damage was less increased in group II than group III. The greater damage in group III may be attributed to the longer duration of enrofloxacin administration compared to oxytetracycline and the effect of enrofloxacin on DNA. The results obtained from this study suggest that usage of oxytetracycline and especially enrofloxacin should be restricted and antibiotics with fewer side effects on sperm should be preferred in Saanen bucks during the reproduction period

FIG. 4 in Biological activity of some Romanian and Turkish Trichoderma Pers. strains

FIG. 4. — Clear inhibition zone revealed by the Trichoderma spp. crude extract against some human pathogenic bacteria.Published as part of <i>Tunç, Gülhan, Boiu-Sicuia, Oana-Alina, Şahiner, Aslı, Kuzucu, Volkan, Dogan, Nazime Mercan & Langerholc, Tomaž, 2023, Biological activity of some Romanian and Turkish Trichoderma Pers. strains, pp. 135-145 in Cryptogamie, Mycologie 20 (10)</i> on page 141, DOI: 10.5252/cryptogamie-mycologie2023v44a10, <a href="http://zenodo.org/record/10144278">http://zenodo.org/record/10144278</a&gt

FIG. 1 in Biological activity of some Romanian and Turkish Trichoderma Pers. strains

FIG. 1. — In vitro antifungal activity of tested Trichoderma strains Ș4 (2), Td-Exp1 (3) and Td-Exp2 (4) against various plant pathogens (1), such as Fusarium culmorum (Wm.G.Sm.) Sacc. (A), F. oxysporum Schltdl. (B), Macrophomina phaseolina (Tassi) Goid. (C) and Sclerotinia sclerotiorum (Lib.) de Bary (D). Scale bars: 1 cm.Published as part of <i>Tunç, Gülhan, Boiu-Sicuia, Oana-Alina, Şahiner, Aslı, Kuzucu, Volkan, Dogan, Nazime Mercan & Langerholc, Tomaž, 2023, Biological activity of some Romanian and Turkish Trichoderma Pers. strains, pp. 135-145 in Cryptogamie, Mycologie 20 (10)</i> on page 139, DOI: 10.5252/cryptogamie-mycologie2023v44a10, <a href="http://zenodo.org/record/10144278">http://zenodo.org/record/10144278</a&gt

FIG. 5 in Biological activity of some Romanian and Turkish Trichoderma Pers. strains

FIG. 5. — Metabolic activity in biofilm and antibiofilm effect of Trichoderma spp. against human pathogenic bacterial strains. Symbols: ns, no significant; *, p <0.05; **, p <0.01; ***, p <0.001; ****, p <0.0001.Published as part of <i>Tunç, Gülhan, Boiu-Sicuia, Oana-Alina, Şahiner, Aslı, Kuzucu, Volkan, Dogan, Nazime Mercan & Langerholc, Tomaž, 2023, Biological activity of some Romanian and Turkish Trichoderma Pers. strains, pp. 135-145 in Cryptogamie, Mycologie 20 (10)</i> on page 142, DOI: 10.5252/cryptogamie-mycologie2023v44a10, <a href="http://zenodo.org/record/10144278">http://zenodo.org/record/10144278</a&gt