Real-time Monitoring for the Next Core-Collapse Supernova in JUNO

Core-collapse supernova (CCSN) is one of the most energetic astrophysical events in the Universe. The early and prompt detection of neutrinos before (pre-SN) and during the SN burst is a unique opportunity to realize the multi-messenger observation of the CCSN events. In this work, we describe the monitoring concept and present the sensitivity of the system to the pre-SN and SN neutrinos at the Jiangmen Underground Neutrino Observatory (JUNO), which is a 20 kton liquid scintillator detector under construction in South China. The real-time monitoring system is designed with both the prompt monitors on the electronic board and online monitors at the data acquisition stage, in order to ensure both the alert speed and alert coverage of progenitor stars. By assuming a false alert rate of 1 per year, this monitoring system can be sensitive to the pre-SN neutrinos up to the distance of about 1.6 (0.9) kpc and SN neutrinos up to about 370 (360) kpc for a progenitor mass of 30$M_{\odot}$ for the case of normal (inverted) mass ordering. The pointing ability of the CCSN is evaluated by using the accumulated event anisotropy of the inverse beta decay interactions from pre-SN or SN neutrinos, which, along with the early alert, can play important roles for the followup multi-messenger observations of the next Galactic or nearby extragalactic CCSN.Comment: 24 pages, 9 figure

Targeting γδ T lymphocytes for cancer immunotherapy : from novel mechanistic insight to clinical application

© 2010 American Association for Cancer ResearchAbundant interferon-γ secretion, potent cytotoxicity, and major histocompatibility complex–independent targeting of a large spectrum of tumors make γδ T cells attractive mediators of cancer immunotherapy. However, a better understanding of the molecular mechanisms involved in tumor cell recognition and γδ T-cell activation is required to improve the limited success of gd T-cell–mediated treatments. Here, we review key advances in basic knowledge made over the past 3 years, and summarize the results of γδ T-cell–based clinical trials concluded to date. We also highlight new research directions on the basis of the modulation of receptors that control the function of γδ T cells.European Molecular Biology Organization (Installation Grant) and Fundação para a Ciência e Tecnologia (PTDC/BIA-BCM/71663/2006)

JUNO's sensitivity to 7Be, pep and CNO solar neutrinos and strategy for directional analysis of CNO solar neutrinos in JUNO

JUNO Experiment is 20 kt multipurpose LS detector, under construction in China, with planned completion in 2023. Its main goal is Neutrino Mass Ordering determination, exploiting its large target mass and excellent energy resolution (3% at 1 MeV). Due to its unique properties, JUNO will have potential of real-time solar neutrino measurement with unprecedented levels of precision using multivariate (MV) fit. Sensitivity study is performed by considering all possible sources of background, including their various concentration level and full simulation of detector response. Performing directional analysis of CNO solar neutrinos via Correlated and Integrated Directionality method (developed by Borexino collaboration) in JUNO and using it as additional constraint in MV fit has potential to further improve precision of CNO solar neutrino measurement. This talk will summarize methods for sensitivity studies using MV fit and the final results. Investigation of Cherenkov and scintillation light properties using JUNO MC software and strategies of preliminary directional analysis will be shown

JUNO's sensitivity to 7Be, pep and CNO solar neutrinos and strategy for directional analysis of CNO solar neutrinos in JUNO

JUNO Experiment is 20 kt multipurpose LS detector, under construction in China, with planned completion in 2023. Its main goal is Neutrino Mass Ordering determination, exploiting its large target mass and excellent energy resolution (3% at 1 MeV). Due to its unique properties, JUNO will have potential of real-time solar neutrino measurement with unprecedented levels of precision using multivariate (MV) fit. Sensitivity study is performed by considering all possible sources of background, including their various concentration level and full simulation of detector response. Performing directional analysis of CNO solar neutrinos via Correlated and Integrated Directionality method (developed by Borexino collaboration) in JUNO and using it as additional constraint in MV fit has potential to further improve precision of CNO solar neutrino measurement. This talk will summarize methods for sensitivity studies using MV fit and the final results. Investigation of Cherenkov and scintillation light properties using JUNO MC software and strategies of preliminary directional analysis will be shown

Atmospheric neutrino reconstruction for the neutrino mass ordering measurement of JUNO

The Jiangmen Underground Neutrino Observatory (JUNO) is a multipurpose liquid scintillator-based neutrino experiment with a target mass of 20 kt. The detector is currently under construction and expected to be completed by the end of 2023. Its main goal is the determination of the neutrino mass ordering (MO), through a measurement of the oscillation pattern of reactor anti-neutrinos over a 53 km baseline. As the largest liquid-scintillator detector, JUNO will also be able to observe atmospheric neutrinos events in the GeV region and down to sub-GeV. Therefore, the sensitivity of JUNO to the neutrino mass ordering can be enhanced from 3 to at least 4 sigma in 6 years via a combined analysis of reactor anti-neutrinos with atmospheric neutrinos. Such an analysis requires a precise knowledge on the track of atmospheric neutrinos, which is challenging in terms of reconstruction of the isotropic scintillation light emitted in JUNO. To achieve this target performance, a novel track reconstruction technique based on the voxelized distribution of optical photon emissions is being developed. The current status of this method will be presented in this talk

Atmospheric neutrino reconstruction for the neutrino mass ordering measurement of JUNO

The Jiangmen Underground Neutrino Observatory (JUNO) is a multipurpose liquid scintillator-based neutrino experiment with a target mass of 20 kt. The detector is currently under construction and expected to be completed by the end of 2023. Its main goal is the determination of the neutrino mass ordering (MO), through a measurement of the oscillation pattern of reactor anti-neutrinos over a 53 km baseline. As the largest liquid-scintillator detector, JUNO will also be able to observe atmospheric neutrinos events in the GeV region and down to sub-GeV. Therefore, the sensitivity of JUNO to the neutrino mass ordering can be enhanced from 3 to at least 4 sigma in 6 years via a combined analysis of reactor anti-neutrinos with atmospheric neutrinos. Such an analysis requires a precise knowledge on the track of atmospheric neutrinos, which is challenging in terms of reconstruction of the isotropic scintillation light emitted in JUNO. To achieve this target performance, a novel track reconstruction technique based on the voxelized distribution of optical photon emissions is being developed. The current status of this method will be presented in this talk

Event builder and online monitoring of OSIRIS pre-detector of JUNO

JUNO is a 20 kt liquid scintillator detector under construction in Jiangmen, China. The installation is expected to be completed in 2023. Its main goal is to determine the neutrino mass hierarchy with the measurement of reactor anti-neutrinos from the two nuclear power plants in the proximity. This requires stringent limits on the radiopurity of the liquid scintillator. The OSIRIS (Online Scintillator Internal Radioactivity Investigation System) pre-detector is designed to monitor the liquid scintillator during the several months of filling the large volume of JUNO. OSIRIS will contain 18 tons of scintillator and will be equipped with 76 20-inch PMTs. It will be sensitive for the $^{238}$U/$^{232}$Th decay rates via tagging of the Bi-Po coincidence decays in the $^{238}$U/$^{232}$Th decay chain. This talk will present the trigger strategies of OSIRIS and its updated event builder software. The online monitoring software for OSIRIS is needed for a live measurement of scintillator radiopurity during filling and it will also be presented in this talk

Event builder and online monitoring of OSIRIS pre-detector of JUNO

JUNO is a 20 kt liquid scintillator detector under construction in Jiangmen, China. The installation is expected to be completed in 2023. Its main goal is to determine the neutrino mass hierarchy with the measurement of reactor anti-neutrinos from the two nuclear power plants in the proximity. This requires stringent limits on the radiopurity of the liquid scintillator. The OSIRIS (Online Scintillator Internal Radioactivity Investigation System) pre-detector is designed to monitor the liquid scintillator during the several months of filling the large volume of JUNO. OSIRIS will contain 18 tons of scintillator and will be equipped with 76 20-inch PMTs. It will be sensitive for the 238U/232Th decay rates via tagging of the Bi-Po coincidence decays in the 238U/232Th decay chain. This talk will present the trigger strategies of OSIRIS and its updated event builder software. The online monitoring software for OSIRIS is needed for a live measurement of scintillator radiopurity during filling and it will also be presented in this talk

Calibration of the JUNO pre-detector OSIRIS

The 20-kton liquid scintillator detector (LS) of the Jiangmen Underground Neutrino Observatory (JUNO) experiment, currently under construction in southern China, has a huge potential for insights in several fields of particle physics. To achieve its many goals, stringent radiopurity requirements have to be fulfilled. In order to ensure these limits, the Online Scintillator Internal Radioactivity Investigation System (OSIRIS) was designed as a pre-detector for JUNO. During the months-long filling of JUNO, OSIRIS will closely assess the radiopurity of purified LS batches to allow fast countermeasures in case of contaminations. In OSIRIS, an array of 76 Large Photomultiplier Tubes (LPMTs) instruments a water-shielded 20-ton LS target. An Automatic Calibration Unit (ACU) from the Daya Bay experiment is used for the calibration of event and vertex reconstruction as well as LPMT timing and charge responses. A separate laser system is used for redundant LPMT timing and charge calibration. This presentation will summarize the current status of the calibration strategy of OSIRIS